水苏糖

Stachyose

	产品编号	CFN90424
	CAS编号	10094-58-3
	分子式 = 分子量	C₂₄H₄₂O₂₁ = 666.57
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The herbs of Lycopus lucidus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
水苏糖	CFN90424	10094-58-3	10mg	QQ客服：2056216494
水苏糖	CFN90424	10094-58-3	20mg	QQ客服：2056216494
水苏糖	CFN90424	10094-58-3	50mg	QQ客服：2056216494
水苏糖	CFN90424	10094-58-3	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Stachyose, as prebiotics, can prevent indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine.Stachyose inhibits Caco-2 cell proliferation and induces apoptosis in a dose-dependent manner. Stachyose with an RS3 carrier has better preventative effects on colitis than Stachyose alone in mice.

Targets:

Bcl-2/Bax | P450 (e.g. CYP17) | Caspase | IL Receptor | TNF-α

In vitro:

Food Funct. 2015 Mar 11;6(3):765-71.

Stachyose-induced apoptosis of Caco-2 cells via the caspase-dependent mitochondrial pathway.[Pubmed: 25578308]

Some studies have shown that stachyose, as prebiotics, can prevent indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine. However, its direct inhibitory effects on cancer cells are still unclear. Thus, this study aims to investigate the direct inhibitory effect of stachyose on human colon cancer cells and determine the molecular mechanism underlying this effect.
METHODS AND RESULTS:
The MTT assay was used to assess the inhibitory effect of stachyose on Caco-2 cells. Apoptosis and mitochondrial membrane potential (ΔΨm) measurements were analyzed using flow cytometry. The activities and mRNA expressions of caspases 3 and 9 were determined using caspase assay kits and quantitative real-time polymerase chain reaction. The apoptotic protein expressions of Bcl-2, Bax, and cytochrome C (Cyt C) were detected through western blotting. Results showed that stachyose inhibits Caco-2 cell proliferation and induces apoptosis in a dose-dependent manner. After pretreatment with 0.4, 0.8, 1.6 and 3.2 mg mL(-1) stachyose, cell inhibitory rates of 15.31% ± 3.20%, 28.45% ± 2.10%, 40.23% ± 5.70%, and 55.67% ± 4.50% were respectively obtained. Compared with the control, decreases in ΔΨm, increases in caspase 3 and 9 activities and mRNA expressions, down-regulation of Bcl-2 protein expression, up-regulation of the Bax protein and Cyt C release of Caco-2 cells were clearly observed upon exposure to different stachyose concentrations.
CONCLUSIONS:
The inhibitory mechanism of stachyose on Caco-2 cells involves the caspase-dependent mitochondrial apoptosis pathway.

In vivo:

Exp Ther Med. 2013 Nov;6(5):1312-1316.

Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium-induced ulcerative colitis in C57BL/6 mice.[Pubmed: 24223664]

METHODS AND RESULTS:
The aim of this study was to determine the effects of resistant starch 3 (RS3) as a carrier for stachyose on dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. RS3 microspheres carrying stachyose (RS3 + stachyose) were produced and evaluated as a potentially improved colitis therapy for this study. The body weights of the mice treated with RS3 + stachyose were higher compared with those of DSS-treated control mice. RS3 + stachyose reduced the levels of the serum pro-inflammatory cytokines IL-6 and TNF-α to a greater extent compared with the same concentration of stachyose combined with ordinary starch (stachyose + starch). Histopathological examination of sections of colon tissues showed that the RS3 + stachyose group recovered well from colitis; however, the tissue sections of the stachyose + starch group presented necrosis to a more serious degree.
CONCLUSIONS:
These results suggest that stachyose with an RS3 carrier has better preventative effects on colitis than stachyose alone in mice.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
蔗果六糖; 1,1,1,1-Kestohexaose	CFN91617	62512-19-0	C₃₆H₆₂O₃₁ = 990.9	5mg	QQ客服：2056216494
甲基-β-环糊精; beta-Cyclodextrin methyl ethers	CFN90860	128446-36-6	C₅₆H₉₈O₃₅ = 1331.3	20mg	QQ客服：3257982914
异麦芽酮糖醇; Isomalt	CFN91476	64519-82-0	C₁₂H₂₄O₁₁ = 344.3	20mg	QQ客服：215959384
麦芽糖; Maltose	CFN91657	69-79-4	C₁₂H₂₂O₁₁ = 342.30	20mg	QQ客服：2159513211
异麦芽糖; Isomaltose	CFN91551	499-40-1	C₁₂H₂₂O₁₁ = 342.3	20mg	QQ客服：2056216494
木二糖; Xylobiose	CFN91630	6860-47-5	C₁₀H₁₈O₉ = 282.24	5mg	QQ客服：1413575084
蔗糖; Sucrose	CFN98970	57-50-1	C₁₂H₂₂O₁₁ = 342.3	20mg	QQ客服：1457312923
D-海藻糖; D-Trehalose	CFN91716	99-20-7	C₁₂H₂₂O₁₁ = 342.30	20mg	QQ客服：3257982914
五水棉子糖; Raffinose	CFN90425	17629-30-0	C₁₈H₃₂O₁₆(₅H₂O) = 594.51	20mg	QQ客服：1413575084
耐斯糖; Nystose	CFN98574	13133-07-8	C₂₄H₄₂O₂₁ = 666.58	20mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5002 mL	7.5011 mL	15.0022 mL	30.0044 mL	37.5054 mL
5 mM	0.3 mL	1.5002 mL	3.0004 mL	6.0009 mL	7.5011 mL
10 mM	0.15 mL	0.7501 mL	1.5002 mL	3.0004 mL	3.7505 mL
50 mM	0.03 mL	0.15 mL	0.3 mL	0.6001 mL	0.7501 mL
100 mM	0.015 mL	0.075 mL	0.15 mL	0.3 mL	0.3751 mL

水苏糖

Stachyose

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