五水棉子糖

Raffinose

	产品编号	CFN90425
	CAS编号	17629-30-0
	分子式 = 分子量	C₁₈H₃₂O₁₆(₅H₂O) = 594.51
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The seeds of Glycine max
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
五水棉子糖	CFN90425	17629-30-0	10mg	QQ客服：1457312923
五水棉子糖	CFN90425	17629-30-0	20mg	QQ客服：1457312923
五水棉子糖	CFN90425	17629-30-0	50mg	QQ客服：1457312923
五水棉子糖	CFN90425	17629-30-0	100mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

After treatment with CVGI, Raffinose family oligosaccharide was hydrolyzed effectively to yield galactose and sucrose. AA-PCD resistance in Raffinose-grown cells occurs with a decrease in both ROS production and cytochrome c release as compared to glucose-grown cells en route to AA-PCD.

Targets:

ROS | P450 (e.g. CYP17)

In vitro:

Biochim Biophys Acta. 2013 Dec;1833(12):2765-74.

Yeast growth in raffinose results in resistance to acetic-acid induced programmed cell death mostly due to the activation of the mitochondrial retrograde pathway.[Pubmed: 23906793 ]

In order to investigate whether and how a modification of mitochondrial metabolism can affect yeast sensitivity to programmed cell death (PCD) induced by acetic acid (AA-PCD), yeast cells were grown on Raffinose, as a sole carbon source, which, differently from glucose, favours mitochondrial respiration.
METHODS AND RESULTS:
We found that, differently from glucose-grown cells, Raffinose-grown cells were mostly resistant to AA-PCD and that this was due to the activation of mitochondrial retrograde (RTG) response, which increased with time, as revealed by the up-regulation of the peroxisomal isoform of citrate synthase and isocitrate dehydrogenase isoform 1, RTG pathway target genes. Accordingly, the deletion of RTG2 and RTG3, a positive regulator and a transcription factor of the RTG pathway, resulted in AA-PCD, as shown by TUNEL assay. Neither deletion in Raffinose-grown cells of HAP4, encoding the positive regulatory subunit of the Hap2,3,4,5 complex nor constitutive activation of the RTG pathway in glucose-grown cells due to deletion of MKS1, a negative regulator of RTG pathway, had effect on yeast AA-PCD. The RTG pathway was found to be activated in yeast cells containing mitochondria, in which membrane potential was measured, capable to consume oxygen in a manner stimulated by the uncoupler CCCP and inhibited by the respiratory chain inhibitor antimycin A.
CONCLUSIONS:
AA-PCD resistance in Raffinose-grown cells occurs with a decrease in both ROS production and cytochrome c release as compared to glucose-grown cells en route to AA-PCD.

In vivo:

J Agric Food Chem. 2013 Aug 14;61(32):7786-93.

Isolation, characterization, and hepatoprotective effects of the raffinose family oligosaccharides from Rehmannia glutinosa Libosch.[Pubmed: 23879777]

This study was aimed to isolate and characterize the Raffinose family oligosaccharides (RGOs) from a novel plant source of Rehmannia glutinosa Libosch, and further evaluate whether RGOs can attenuate CCl4-induced oxidative stress and hepatopathy in mice. HPLC analysis showed that RGOs were mainly composed of stachyose (61.7%, w/w), followed by 23.7% Raffinose and 7.1% sucrose.
METHODS AND RESULTS:
Administration of RGOs orally daily in mice for 21 days significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total-cholesterol (TC), and triglycerides (TG). RGOs also increased antioxidant levels of hepatic glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC), and ameliorated the elevated hepatic formation of malonaldehyde (MDA) induced by CCl4 in mice, which coincided with the histological alteration.
CONCLUSIONS:
These findings exhibited the potential prospect of RGOs as functional ingredients to prevent ROS-related liver damage.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
木二糖; Xylobiose	CFN91630	6860-47-5	C₁₀H₁₈O₉ = 282.24	5mg	QQ客服：215959384
蔗糖; Sucrose	CFN98970	57-50-1	C₁₂H₂₂O₁₁ = 342.3	20mg	QQ客服：2056216494
D-海藻糖; D-Trehalose	CFN91716	99-20-7	C₁₂H₂₂O₁₁ = 342.30	20mg	QQ客服：3257982914
五水棉子糖; Raffinose	CFN90425	17629-30-0	C₁₈H₃₂O₁₆(₅H₂O) = 594.51	20mg	QQ客服：2056216494
耐斯糖; Nystose	CFN98574	13133-07-8	C₂₄H₄₂O₂₁ = 666.58	20mg	QQ客服：3257982914
水苏糖; Stachyose	CFN90424	10094-58-3	C₂₄H₄₂O₂₁ = 666.57	20mg	QQ客服：1457312923
阿卡波糖; Acarbose	CFN91170	56180-94-0	C₂₅H₄₃NO₁₈ = 645.6	20mg	QQ客服：3257982914
麦芽三糖; Maltotriose	CFN91550	1109-28-0	C₁₈H₃₂O₁₆ = 504.4	20mg	QQ客服：1413575084
麦芽四糖; Maltotetraose	CFN90871	34612-38-9	C₂₄H₄₂O₂₁ = 666.6	20mg	QQ客服：2056216494
麦芽五糖; Maltopentaose	CFN91478	34620-76-3	C₃₀H₅₂O₂₆ = 828.7	20mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6821 mL	8.4103 mL	16.8206 mL	33.6411 mL	42.0514 mL
5 mM	0.3364 mL	1.6821 mL	3.3641 mL	6.7282 mL	8.4103 mL
10 mM	0.1682 mL	0.841 mL	1.6821 mL	3.3641 mL	4.2051 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL

五水棉子糖

Raffinose

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