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  • 五水棉子糖

    Raffinose

    五水棉子糖
    产品编号 CFN90425
    CAS编号 17629-30-0
    分子式 = 分子量 C18H32O16(5H2O) = 594.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The seeds of Glycine max
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五水棉子糖 CFN90425 17629-30-0 10mg QQ客服:215959384
    五水棉子糖 CFN90425 17629-30-0 20mg QQ客服:215959384
    五水棉子糖 CFN90425 17629-30-0 50mg QQ客服:215959384
    五水棉子糖 CFN90425 17629-30-0 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Copenhagen University (Denmark)
  • Universiti Sains Malaysia (Malaysia)
  • Charles University in Prague (Czech Republic)
  • Florida International University (USA)
  • University of Parma (Italy)
  • Stanford University (USA)
  • Chulalongkorn University (Thailand)
  • Universitas islam negeri Jakarta (Indonesia)
  • Weizmann Institute of Science (Israel)
  • University of South Australia (Australia)
  • Universidade da Beira Interior (Germany)
  • University of Maryland School of Medicine (USA)
  • Medizinische Universit?t Wien (Austria)
  • S.N.D.T. Women's University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol. 2020, 83:106403.
  • J Food Composition and Analysis2022, 104417.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Plants (Basel).2021, 10(7):1376.
  • BMC Complement Med Ther.2023, 23(1):264.
  • Biomed Pharmacother.2022, 146:112497.
  • J Food Compos Anal2017, 62:197-204
  • Biomolecules.2021, 11(10):1537.
  • Phytother Res.2019, 33(3):676-689
  • Plant Physiol Biochem.2023, 201:107795.
  • Journal of Chromatography A2020, 460942
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • Food Chem.2017, 221:1135-1144
  • Biomed Chromatogr.2016, 30(10):1573-81
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Primary and Industrial.2018, 52(11)
  • Tumour Biol.2015, 36(12):9385-93
  • Heliyon2020, 6(6):e04337.
  • Antioxidants (Basel).2022, 11(8):1471.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • ...
  • 生物活性
    Description: After treatment with CVGI, Raffinose family oligosaccharide was hydrolyzed effectively to yield galactose and sucrose. AA-PCD resistance in Raffinose-grown cells occurs with a decrease in both ROS production and cytochrome c release as compared to glucose-grown cells en route to AA-PCD.
    Targets: ROS | P450 (e.g. CYP17)
    In vitro:
    Biochim Biophys Acta. 2013 Dec;1833(12):2765-74.
    Yeast growth in raffinose results in resistance to acetic-acid induced programmed cell death mostly due to the activation of the mitochondrial retrograde pathway.[Pubmed: 23906793 ]
    In order to investigate whether and how a modification of mitochondrial metabolism can affect yeast sensitivity to programmed cell death (PCD) induced by acetic acid (AA-PCD), yeast cells were grown on Raffinose, as a sole carbon source, which, differently from glucose, favours mitochondrial respiration.
    METHODS AND RESULTS:
    We found that, differently from glucose-grown cells, Raffinose-grown cells were mostly resistant to AA-PCD and that this was due to the activation of mitochondrial retrograde (RTG) response, which increased with time, as revealed by the up-regulation of the peroxisomal isoform of citrate synthase and isocitrate dehydrogenase isoform 1, RTG pathway target genes. Accordingly, the deletion of RTG2 and RTG3, a positive regulator and a transcription factor of the RTG pathway, resulted in AA-PCD, as shown by TUNEL assay. Neither deletion in Raffinose-grown cells of HAP4, encoding the positive regulatory subunit of the Hap2,3,4,5 complex nor constitutive activation of the RTG pathway in glucose-grown cells due to deletion of MKS1, a negative regulator of RTG pathway, had effect on yeast AA-PCD. The RTG pathway was found to be activated in yeast cells containing mitochondria, in which membrane potential was measured, capable to consume oxygen in a manner stimulated by the uncoupler CCCP and inhibited by the respiratory chain inhibitor antimycin A.
    CONCLUSIONS:
    AA-PCD resistance in Raffinose-grown cells occurs with a decrease in both ROS production and cytochrome c release as compared to glucose-grown cells en route to AA-PCD.
    In vivo:
    J Agric Food Chem. 2013 Aug 14;61(32):7786-93.
    Isolation, characterization, and hepatoprotective effects of the raffinose family oligosaccharides from Rehmannia glutinosa Libosch.[Pubmed: 23879777]
    This study was aimed to isolate and characterize the Raffinose family oligosaccharides (RGOs) from a novel plant source of Rehmannia glutinosa Libosch, and further evaluate whether RGOs can attenuate CCl4-induced oxidative stress and hepatopathy in mice. HPLC analysis showed that RGOs were mainly composed of stachyose (61.7%, w/w), followed by 23.7% Raffinose and 7.1% sucrose.
    METHODS AND RESULTS:
    Administration of RGOs orally daily in mice for 21 days significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total-cholesterol (TC), and triglycerides (TG). RGOs also increased antioxidant levels of hepatic glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC), and ameliorated the elevated hepatic formation of malonaldehyde (MDA) induced by CCl4 in mice, which coincided with the histological alteration.
    CONCLUSIONS:
    These findings exhibited the potential prospect of RGOs as functional ingredients to prevent ROS-related liver damage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6821 mL 8.4103 mL 16.8206 mL 33.6411 mL 42.0514 mL
    5 mM 0.3364 mL 1.6821 mL 3.3641 mL 6.7282 mL 8.4103 mL
    10 mM 0.1682 mL 0.841 mL 1.6821 mL 3.3641 mL 4.2051 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蔗果五糖; 1,1,1-Kestopentaose CFN93044 59432-60-9 C30H52O26 = 828.72 20mg QQ客服:3257982914
    蔗果六糖; 1,1,1,1-Kestohexaose CFN91617 62512-19-0 C36H62O31 = 990.9 5mg QQ客服:3257982914
    甲基-β-环糊精; beta-Cyclodextrin methyl ethers CFN90860 128446-36-6 C56H98O35 = 1331.3 20mg QQ客服:2056216494
    异麦芽酮糖醇; Isomalt CFN91476 64519-82-0 C12H24O11 = 344.3 20mg QQ客服:1413575084
    麦芽糖; Maltose CFN91657 69-79-4 C12H22O11 = 342.30 20mg QQ客服:3257982914
    异麦芽糖; Isomaltose CFN91551 499-40-1 C12H22O11 = 342.3 20mg QQ客服:1457312923
    木二糖; Xylobiose CFN91630 6860-47-5 C10H18O9 = 282.24 5mg QQ客服:1413575084
    蔗糖; Sucrose CFN98970 57-50-1 C12H22O11 = 342.3 20mg QQ客服:2159513211
    D-海藻糖; D-Trehalose CFN91716 99-20-7 C12H22O11 = 342.30 20mg QQ客服:2056216494
    五水棉子糖; Raffinose CFN90425 17629-30-0 C18H32O16(5H2O) = 594.51 20mg QQ客服:2159513211

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