西伯利亚远志呫吨酮B
Sibiricaxanthone B
|
|
产品编号 |
CFN90644 |
| CAS编号 |
241125-81-5 |
| 分子式 = 分子量 |
C24H26O14 = 538.45 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Xanthones |
| 植物来源 |
The roots of Polygala tenuifolia |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 西伯利亚远志呫吨酮B |
CFN90644 |
241125-81-5 |
10mg |
QQ客服：1457312923 |
| 西伯利亚远志呫吨酮B |
CFN90644 |
241125-81-5 |
20mg |
QQ客服：1457312923 |
| 西伯利亚远志呫吨酮B |
CFN90644 |
241125-81-5 |
50mg |
QQ客服：1457312923 |
| 西伯利亚远志呫吨酮B |
CFN90644 |
241125-81-5 |
100mg |
QQ客服：1457312923 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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National Research Council of Canada (Canada)
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Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
Sanford Burnham Medical Research Institute (USA)
Instytut Nawozów Sztucznych w Pu?awach (Poland)
University of Illinois (USA)
Macau University of Science and Technology (China)
Sanford Burnham Prebys Medical Discovery Institute (USA)
Chungnam National University (Korea)
The Institute of Cancer Research (United Kingdom)
Mahatma Gandhi University (India)
University of Indonesia (Indonesia)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Nutrients.2019, 11(11):E2694
Sci Rep.2023, 13(1):14594.
Plant Sci.2020, 301:110656.
Toxins (Basel).2022, 14(12):824.
Cosmetics2021, 8(3),91.
J AOAC Int.2021, 104(6):1634-1651.
Auburn University2015, 1-58
Int J Mol Sci.2020, 21(19),7070.
| Description: |
Sibiricaxanthone B is a natural product from Polygala tenuifolia. |
| In vivo: |
| J Sep Sci. 2017 May;40(10):2131-2140. | | Ultra-fast liquid chromatography with tandem mass spectrometry determination of eight bioactive components of Kai-Xin-San in rat plasma and its application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats.[Pubmed: 28342292] | A method of ultra-fast liquid chromatography with tandem mass spectrometry was developed and validated for the simultaneous quantitation of eight bioactive components, including polygalaxanthone III, Sibiricaxanthone B, tenuifolin, sibiricose A5, sibiricose A6, tenuifoliside A, ginsenoside Re and ginsenoside Rb1 in rat plasma after oral administration of Kai-Xin-San.
METHODS AND RESULTS:
The plasma samples were extracted by liquid-liquid extraction using digoxin as an internal standard. Chromatographic separation was performed on a Venusil MP C18 column (100 mm × 2.1 mm, 3 μm) with methanol and 0.05% acetic acid in water as mobile phase. The tandem mass spectrometric detection was performed in the multiple reaction monitoring with turbo ion spray source in the negative ionization. Validation parameters were within acceptable ranges. The established method has been successfully applied to compare the pharmacokinetic profiles of the analytes between normal and Alzheimer's disease rats.
CONCLUSIONS:
The results indicated that there were significant differences in pharmacokinetic parameters of some components between two groups, which may be due to the mechanisms of Alzheimer's disease and pharmacological effects of the analytes. The pharmacokinetic research in the pathological state might provide more useful information to guide the clinical usage of herbal medicine. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.8572 mL |
9.2859 mL |
18.5718 mL |
37.1437 mL |
46.4296 mL |
| 5 mM |
0.3714 mL |
1.8572 mL |
3.7144 mL |
7.4287 mL |
9.2859 mL |
| 10 mM |
0.1857 mL |
0.9286 mL |
1.8572 mL |
3.7144 mL |
4.643 mL |
| 50 mM |
0.0371 mL |
0.1857 mL |
0.3714 mL |
0.7429 mL |
0.9286 mL |
| 100 mM |
0.0186 mL |
0.0929 mL |
0.1857 mL |
0.3714 mL |
0.4643 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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