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  • 远志山酮III

    Polygalaxanthone III

    远志山酮III
    产品编号 CFN90208
    CAS编号 162857-78-5
    分子式 = 分子量 C25H28O15 = 568.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Xanthones
    植物来源 The roots of Polygala tenuifolia Willd.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    远志山酮III CFN90208 162857-78-5 10mg QQ客服:3257982914
    远志山酮III CFN90208 162857-78-5 20mg QQ客服:3257982914
    远志山酮III CFN90208 162857-78-5 50mg QQ客服:3257982914
    远志山酮III CFN90208 162857-78-5 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytother Res.2016, 30(12):2020-2026
  • J Nat Med.2020, 74(1):65-75
  • Biomedicines.2022, 10(2):463.
  • Food Bioscience2022, 50:102187.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Industrial Crops and Products2018, 353-362
  • J Anal Toxicol.2021, bkab015.
  • Nutr Cancer.2022, 1-13.
  • Appl Biol Chem2019, 62:46
  • Pharm Biol.2017, 55(1):360-366
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Processes2021, 9(11),2065.
  • Front. Pharmacol.2022, 901563.
  • J Nat Prod.2022, 85(5):1351-1362.
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Anat Rec2018, 24264
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • BMC Plant Biol.2018, 18(1):122
  • Academic J of Second Military Medical University2019, 40(1)
  • Molecules.2019, 24(21):E3834
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • Sci Rep.2021, 11(1):14180.
  • ...
  • 生物活性
    Description: Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4459-63.
    [Effect of oligosaccharide esters and polygalaxanthone Ill from Polygala tenuifolia willd towards cytochrome P450].[Pubmed: 25850285]

    METHODS AND RESULTS:
    Five compounds (tenuifoliside C, tenuifoliside D, telephiose A, telephiose C and polygalaxanthone III) from polygala tenuifolia wild were incubated together with CYP probe substrate in human liver microsomes to investigate the inhibitory effect towards CYP450 enzyme. Phenacetin (CYP1A2), coumarin (CYP2A6), paclitaxel (CYP2C8), diclofenac (CYP2C9), S-mepheriytoin (CYP2C19), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1), midazolam (CYP3A) were selected as the isoforfn specific substrate. And the formation of paracetamol, 7-hydroxycoumarin, 6alpha-hydroxy paclitaxel, 4'-hydroxydiclofenac, dextrorphan, 6-hydroxychlorzoxazone, 1'-hydroxymidazolam, 4'-hydroxymephenytoin were detected respectively to measure the effect towards CYP450 by high-pressure liquid chromatography (HPLC).
    CONCLUSIONS:
    The result shows that five compounds from polygala tenuifolia willd significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, while showed no effect towards CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A. And IC50 value was 38.73, 54.14, 61.77, 62.22, 50.56 micromol x L(-1), respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7594 mL 8.7968 mL 17.5936 mL 35.1871 mL 43.9839 mL
    5 mM 0.3519 mL 1.7594 mL 3.5187 mL 7.0374 mL 8.7968 mL
    10 mM 0.1759 mL 0.8797 mL 1.7594 mL 3.5187 mL 4.3984 mL
    50 mM 0.0352 mL 0.1759 mL 0.3519 mL 0.7037 mL 0.8797 mL
    100 mM 0.0176 mL 0.088 mL 0.1759 mL 0.3519 mL 0.4398 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新芒果苷; Neomangiferin CFN98122 64809-67-2 C25H28O16 = 584.48 20mg QQ客服:215959384
    芒果苷; 芒果甙; Mangiferin CFN98719 4773-96-0 C19H18O11 = 422.3 20mg QQ客服:2056216494
    高芒果苷; Homomangiferin CFN80148 21794-66-1 C20H20O11 = 436.36 5mg QQ客服:1413575084
    7-O-甲基芒果素; 7-O-Methylmangiferin CFN90667 31002-12-7 C20H20O11 = 436.37 20mg QQ客服:215959384
    远志山酮III; Polygalaxanthone III CFN90208 162857-78-5 C25H28O15 = 568.39 20mg QQ客服:2159513211
    远志咕吨酮Ⅺ; Polygalaxanthone XI CFN89072 857859-82-6 C25H28O15 = 568.48 20mg QQ客服:1413575084
    西伯利亚远志呫吨酮B; Sibiricaxanthone B CFN90644 241125-81-5 C24H26O14 = 538.45 20mg QQ客服:215959384
    当药醇苷; Swertianolin CFN90618 23445-00-3 C20H20O11 = 436.37 10mg QQ客服:2056216494
    4-β-D-葡萄糖基-1,3,7-三羟基呫吨酮; Lancerin CFN90666 81991-99-3 C19H18O10 = 406.34 5mg QQ客服:1413575084
    异芒果苷; 异杞果素; Isomangiferin CFN90385 24699-16-9 C19H18O11 = 422.34 20mg QQ客服:2056216494

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