| In vitro: |
| Zhongguo Yao Li Xue Bao. 1989 Jan;10(1):85-90. | | Antiviral effect of mangiferin and isomangiferin on herpes simplex virus[Pubmed: 2554669] |
METHODS AND RESULTS:
Using tissue culture techniques the present study assured us of the merits of mangiferin and Isomangiferin in the antiviral action against HSV-1. Utilizing 4 main patterns for evaluating drug effectiveness (ie intratube drug-on-virus direct action, simultaneous addition of drug-virus-inoculum to cell bottle, virus inoculation preceding drug addition, and drug addition followed by virus inoculation), it was readily found by logarithm determination of HSV-I inhibition that Isomangiferin was superior to such control drugs as acyclovir, idoxuridine, and cyclocytidine in logarithm by 0.27-0.50, and that mangiferin was lower than Isomangiferin in logarithm by 0.53. The average plaque reduction rates of mangiferin and Isomangiferin were 69.5% and 56.8%, respectively.
CONCLUSIONS:
All in all, the antiviral effect of mangiferin and Isomangiferin was attributed presumably to their capability to inhibit virus replication within cells. | | J Nat Prod. 2008 Nov;71(11):1887-90. | | Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera.[Pubmed: 18950229] |
METHODS AND RESULTS:
Chemical investigation of the methanol extract from the leaves of Arrabidaea patellifera, a Bignoniaceae from Panama, afforded mangiferin, Isomangiferin, and six new derivatives (3'-O-p-hydroxybenzoylmangiferin, 3'-O-trans-coumaroylmangiferin, 6'-O-trans-coumaroylmangiferin, 3'-O-trans-cinnamoylmangiferin, 3'-O-trans-caffeoylmangiferin, and 3'-O-benzoylmangiferin). All these compounds had antioxidant and radical-scavenging activities, and four of them were relatively active in vitro against Plasmodium falciparum.
CONCLUSIONS:
The structures were determined by spectrometric and chemical methods, including 1D and 2D NMR experiments and MS analysis. |
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