紫菀酮

Shionone

	产品编号	CFN99784
	CAS编号	10376-48-4
	分子式 = 分子量	C₃₀H₅₀O = 426.72
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The flowers of Chrysanthemum morifolium
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
紫菀酮	CFN99784	10376-48-4	10mg	QQ客服：215959384
紫菀酮	CFN99784	10376-48-4	20mg	QQ客服：215959384
紫菀酮	CFN99784	10376-48-4	50mg	QQ客服：215959384
紫菀酮	CFN99784	10376-48-4	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Shionone has anti-inflammatory effect, the mechanism is related to decrease the phosphorylation level of ERK1/2 protein and IκBα and the protein expression of i NOS. It can inhibit the activity of ubiquitin-specific protease 2 (USP2) and provide a lead compound for future development of new USP2 inhibitors.

Targets:

ERK | IkB | NOS | IKK

In vitro:

China Journal of Traditional Chinese Medicine & Pharmacy, 2016(4):1430-3.

Study on anti-inflammatory mechanism of shionone based on NF-κB pathway in vitro.[Reference: WebLink]

To explore anti-inflammatory effect and mechanism of shionone in vitro.
METHODS AND RESULTS:
Lipopolysaccharide(LPS)-activated macrophage cells(RAW264.7) were employed as an inflammatory model, which was intervened by the shionone. After the experiment, Western blot was used to detect the protein expression of p-ERK1/2, IκBαand iNOS on the macrophage cells. Compared with the LPS group, the shionone significantly decreased the protein expression of p-ERK1/2 and i NOS(P0.05) and significantly increased the protein expression of IκBα(P0.05).
CONCLUSIONS:
The antiinflammatory mechanism of shionone was related to decrease the phosphorylation level of ERK1/2 protein and IκBα and the protein expression of i NOS.

In vivo:

J Ethnopharmacol. 2015 Apr 22;164:328-33.

Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricu[Pubmed: 25701752]

The root of Aster tataricus L. f., recorded in all versions of Chinese Pharmacopoeia, is a traditional Chinese medicine with the function of dispelling phlegm and relieving cough for more than 2000 years. This study was designed to evaluate the expectorant, antitussive, and anti-inflammatory activities of the root of A. tataricus and to explore the chemical substances responsible for these activities.
METHODS AND RESULTS:
The 70% ethanol extract of the root of A. tataricus (RA-70) was divided into three fractions, Fr-0, Fr-50 and Fr-95. They were all orally administrated to the mice to investigate their potential expectorant activities by a tracheal phenol red secretion method. The most effective fraction, together with shionone, was evaluated the expectorant, antitussive and anti-inflammatory activities by the mouse models of phenol red secretion, ammonia-induced cough, and xylene-induced ear swelling. Furthermore, the chemical components of the effective fraction were analyzed and identified by an HPLC-Q-TOF/MS method. Treatment with RA-70, Fr-0 and Fr-50 increased the amount of phenol red secretion by 65.3%, 56.5%, and 76.9%, respectively. Fr-50 was chosen for the further investigation and the results showed that Fr-50 at 40, 80 mg/kg significantly enhanced the phenol red secretion of tracheas, increased the latent period and decreased the frequency of cough and inhibited the ear edema in mice. Shionone at 80 mg/kg showed the trend of enhancing sputum secreting, but had no effect on ammonia-induced cough and xylene-induced ear edema. HPLC-Q-TOF/MS analysis indicated that Fr-50 was mainly composed of 12 caffeoylquinic acids (40.8%, in relative peak area), 7 astersaponins (12.0%) and 13 astins/asterinins (pentapeptides, 26.5%).
CONCLUSIONS:
The root of A. tataricus has significant expectorant, antitussive and anti-inflammatory effects. Caffeoylquinic acids, astersaponins, and aster peptides, rather than shionone, may be the main constituents responsible for the expectorant and antitussive activities of A. tataricus and act in a synergistic way.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3435 mL	11.7173 mL	23.4346 mL	46.8691 mL	58.5864 mL
5 mM	0.4687 mL	2.3435 mL	4.6869 mL	9.3738 mL	11.7173 mL
10 mM	0.2343 mL	1.1717 mL	2.3435 mL	4.6869 mL	5.8586 mL
50 mM	0.0469 mL	0.2343 mL	0.4687 mL	0.9374 mL	1.1717 mL
100 mM	0.0234 mL	0.1172 mL	0.2343 mL	0.4687 mL	0.5859 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
表木栓醇; Friedelanol	CFN98804	5085-72-3	C₃₀H₅₂O = 428.7	5mg	QQ客服：1413575084
表木栓醇; Epifriedelanol	CFN99806	16844-71-6	C₃₀H₅₂O = 428.7	20mg	QQ客服：1457312923
表无羁萜乙酸酯; Epifriedelanol acetate	CFN98223	2259-07-6	C₃₂H₅₄O₂ = 470.8	5mg	QQ客服：1457312923
无羁萜，木栓酮; Friedelin	CFN98936	559-74-0	C₃₀H₅₀O = 426.7	10mg	QQ客服：1457312923
29-羟基无羁萜-3-酮; 29-Hydroxyfriedelan-3-one	CFN98632	39903-21-4	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：215959384
紫菀酮; Shionone	CFN99784	10376-48-4	C₃₀H₅₀O = 426.72	20mg	QQ客服：1413575084

紫菀酮

Shionone

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