| In vitro: |
| Planta Med. 2011 Mar;77(5):441-9. | | Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells.[Pubmed: 21049397] | | Among twenty-two compounds isolated, epifriedelanol (3), ssioriside (15), and catechin-7-O- β-D-glucopyranoside (22) had inhibitory effects on adriamycin-induced cellular senescence in HDFs. Friedelin (2), epifriedelanol (3), and catechin-7-O- β-apiofuranoside (18) were active in HUVECs. In particular, epifriedelanol (3) suppressed adriamycin-induced cellular senescence as well as replicative senescence in HDFs and HUVECs. These results suggest that epifriedelanol (3) reduces cellular senescence in human primary cells and might be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. | | Fitoterapia. 2000 Sep;71(5):577-9. | | Antitumor activity of epifriedelanol from Vitis trifolia.[Pubmed: 11449513] | | The isolation and NMR spectral data of epifriedelanol from Vitis trifolia are reported. It demonstrated antitumor activity in a potato disc bioassay. | | Lat. Am. J. Pharm., 2015, 34(2):291-5. | | Bioactive Constituents from the Rhizomes of Aster tataricus L. f. Afford the Treatment of Asthma through Activation of beta(2)AR and Inhibition of NF-kappa b[Reference: WebLink] | The rhizomes of Aster tataricus L. f. are used as materia medica or prescriptions for the treatment of asthma in Chinese folklore.
METHODS AND RESULTS:
To elucidate the mechanism of asthma treatment by A. tataricus, chemical constituents of this plant have been studied and screening for inhibiting NF-kappa B and activating beta(2) adrenergic receptor of relevant compounds has been performed by dual luciferase reporter assays. As a result, 10 natural compounds have been identified from rhizomes of A. tataricus including beta-sitosterol (1), daucosterol (2), kaempferol (3), quercetin (4), shionone (5), friedelin (6), Epifriedelanol (7), atersaponin A (8), aurantiamide (9), and astin C (10).
CONCLUSIONS:
Of all the 10 compounds obtained, 3, 9 and 10 showed activation of beta(2) adrenergic receptor and 3-9 exhibited significant inhibition of NF-kappa B, which could present evidences of A. tataricus for the treatment of asthma.
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