| In vitro: |
| Molecules. 2011 Jun 10;16(6):4828-35. | | Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance.[Pubmed: 21666549] |
METHODS AND RESULTS:
Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4'-dimethylapigenin, trimethylapigenin, cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance.
CONCLUSIONS:
This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4',5,6,7-Tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold. | | J Med Assoc Thai. 1991 May;74(5):283-7. | | Effect of Eupatorium odoratum on blood coagulation.[Pubmed: 1783877] |
METHODS AND RESULTS:
The purified compound, 4',5,6,7-Tetramethoxyflavone, is an active ingredient isolated from Eupatorium odoratum, a Thai indigenous plant that has long been used to stop bleeding. This compound was studied in vitro for the effect on blood clotting factor activities. It was found that the compound enhanced blood coagulation, the observed APTT being shorter than that observed in the control.
CONCLUSIONS:
The result suggested that the compound accelerated clotting time through the intrinsic pathway of the coagulation which may involve the reaction of factor XII, factor XI, factor IX or factor VIII. |
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