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  • 甜菊双糖苷A

    Rebaudioside A

    甜菊双糖苷A
    产品编号 CFN99110
    CAS编号 58543-16-1
    分子式 = 分子量 C44H70O23 = 967.01
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The leaves of Stevia rebaudiana Bertoni.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甜菊双糖苷A CFN99110 58543-16-1 10mg QQ客服:215959384
    甜菊双糖苷A CFN99110 58543-16-1 20mg QQ客服:215959384
    甜菊双糖苷A CFN99110 58543-16-1 50mg QQ客服:215959384
    甜菊双糖苷A CFN99110 58543-16-1 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • ACS Pharmacol. Transl. Sci.2023, 3c00129.
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  • ...
  • 生物活性
    Description: Rebaudioside A, an natural sweetening ingredient, is approximately 250 to 300 times sweeter than sucrose, do not contribute calories or carbohydrates to the diet and do not affect blood glucose or insulin response. It is a α-glucosidase inhibitor with IC50 of 35.01 μg/ml.
    Targets: α-glucosidase
    In vitro:
    Food Chem Toxicol. 2014 Apr;66:334-40.
    The non-cytotoxicity characterization of rebaudioside A as a food additive.[Pubmed: 24500608]
    To evaluate the cytotoxicity of high-purity rebaudioside A (reb A, 99.16%) as a food ingredient, a combination of several methods, including tetrazolium-based colorimetric assay (MTT), lactate dehydrogenase assay (LDH), enzyme-linked immunosorbent assay (ELISA), real-time PCR (qPCR), high-performance liquid chromatography (HPLC), and two-dimensional electrophoresis (2-DE) were used to test the cytotoxicity of rebaudioside A on the human cells HT-29 and T84, as well as liver and spleen cells from mice. The results indicated that no obvious changes in cellular viability, inflammatory cytokines yield, or protein yield were observed between the test group and the control group when different concentrations of rebaudioside A were used, suggesting that rebaudioside A is non-cytotoxic in vitro at the concentrations range tested (0.001-0.5%).
    Food Chem . 2016 Jun 1;200:154-8.
    Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni[Pubmed: 26830573]
    Abstract Rebaudioside-A is the second most abundant sweet diterpene glycoside (1-3%) present in the leaves of Stevia rebaudiana Bertoni, and is now being considered as a possible sucrose substitute due to its pleasant organoleptic properties and associated health benefits. In the present study, a novel in situ enzymatic transglycosylation of stevioside has been developed by pre-treating the stevia leaves with cellulase and adding soluble starch as the glucosyl donor. The results confirm that the transglycosylation of stevioside led to an enrichment in the rebaudioside-A content from 4% to 66%. This was further purified by multiple column chromatography to obtain 95% pure rebaudioside-A. The isolated rebaudioside-A showed concentration-dependent α-glucosidase inhibitory activity with IC50=35.01 μg/ml. Thus the study highlights the biotransformation of stevioside present in stevia leaves to rebaudioside-A by a simple, inexpensive and eco-friendly process that has commercial potential. Keywords: Cellulase; Glucosyl donors; Rebaudioside-A; Rebaudioside-A (PubChem CID:6918840); Stevia leaves; Stevioside (PubChem CID:442089); Transglycosylation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0341 mL 5.1706 mL 10.3412 mL 20.6823 mL 25.8529 mL
    5 mM 0.2068 mL 1.0341 mL 2.0682 mL 4.1365 mL 5.1706 mL
    10 mM 0.1034 mL 0.5171 mL 1.0341 mL 2.0682 mL 2.5853 mL
    50 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.4136 mL 0.5171 mL
    100 mM 0.0103 mL 0.0517 mL 0.1034 mL 0.2068 mL 0.2585 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甜菊苷; Stevioside CFN99548 57817-89-7 C38H60O18 = 804.88 20mg QQ客服:2159513211
    瑞鲍迪甙F; Rebaudioside F CFN95215 438045-89-7 C43H68O22 = 937.0 5mg QQ客服:3257982914
    甜菊双糖苷A; Rebaudioside A CFN99110 58543-16-1 C44H70O23 = 967.01 20mg QQ客服:1413575084
    莱苞迪甙C; 莱苞迪苷C; Rebaudioside C CFN90258 63550-99-2 C44H70O22 = 951.02 20mg QQ客服:215959384
    13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester; Stevia impurity (13-[(2-O-6-deoxy-beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid beta-D-glucopyranosyl ester) CFN95229 1309929-72-3 C44H70O22 = 951.0 5mg QQ客服:215959384
    莱苞迪甙D; 莱苞迪苷D; Rebaudioside D CFN90257 63279-13-0 C50H80O28 = 1129.15 20mg QQ客服:1413575084
    莱苞迪苷E; Rebaudioside E CFN91096 63279-14-1 C44H70O23 = 967.02 5mg QQ客服:1413575084
    莱苞迪苷N; Rebaudioside N CFN91167 1220616-46-5 C56H90O32 = 1275.9 5mg QQ客服:215959384
    莱苞迪苷M; Rebaudioside M CFN70259 1220616-44-3 C56H90O33 = 1291.3 5mg QQ客服:215959384
    (4alpha,11beta,15beta)-11,15-二羟基贝壳杉-16-烯-18-酸beta-D-吡喃葡萄糖酯; Paniculoside II CFN97019 60129-64-8 C26H40O9 = 496.6 5mg QQ客服:3257982914

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