原花青素B3

Procyanidin B3

	产品编号	CFN99559
	CAS编号	23567-23-9
	分子式 = 分子量	C₃₀H₂₆O₁₂ = 578.52
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The fruits of Vitis vinifera L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
原花青素B3	CFN99559	23567-23-9	1mg	QQ客服：1413575084
原花青素B3	CFN99559	23567-23-9	5mg	QQ客服：1413575084
原花青素B3	CFN99559	23567-23-9	10mg	QQ客服：1413575084
原花青素B3	CFN99559	23567-23-9	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Deutsches Krebsforschungszentrum (Germany)

Utrecht University (Netherlands)

Uniwersytet Jagielloński w Krakowie (Poland)

Almansora University (Egypt)

University of Parma (Italy)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

University of Cincinnati (USA)

Universiti Putra Malaysia(UPM) (Malaysia)

University of Wollongong (Australia)

University of Amsterdam (Netherlands)

University of Melbourne (Australia)

Complutense University of Madrid (Spain)

FORTH-IMBB (Greece)

Weizmann Institute of Science (Israel)

More...

Description:

Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. Procyanidin B3 is an inhibitor of histone acetyltransferase, B3 enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Procyanidin B3 prevents osteoarthritis (OA) progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS, these results support the potential therapeutic benefits of B3 for treatment of human OA and heterotopic ossification.

Targets:

NOS | IL Receptor | Androgen Receptor

In vitro:

PLoS One. 2012;7(5):e37728.

Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model.[Pubmed: 22629448]

Procyanidin B3 (B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. Here, we evaluated the role of Procyanidin B3 isolated from grape seeds in the maintenance of chondrocytes in vitro and in vivo.
METHODS AND RESULTS:
We observed that Procyanidin B3 inhibited H(2)O(2)-induced apoptosis in primary chondrocytes, suppressed H(2)O(2)- or IL-1ß-induced nitric oxide synthase (iNOS) production, and prevented IL-1ß-induced suppression of chondrocyte differentiation marker gene expression in primary chondrocytes. Moreover, Procyanidin B3 treatment enhanced the early differentiation of ATDC5 cells. To examine whether Procyanidin B3 prevents cartilage destruction in vivo, OA was surgically induced in C57BL/6J mice followed by oral administration of Procyanidin B3 or vehicle control. Daily oral Procyanidin B3 administration protected articular cartilage from OA and prevented chondrocyte apoptosis in surgically-induced OA joints. Furthermore, Procyanidin B3 administration prevented heterotopic cartilage formation near the surgical region. iNOS protein expression was enhanced in the synovial tissues and the pseudocapsule around the surgical region in OA mice fed a control diet, but was reduced in mice that received Procyanidin B3. Together, these data indicated that in the OA model, Procyanidin B3 prevented OA progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS.
CONCLUSIONS:
These results support the potential therapeutic benefits of Procyanidin B3 for treatment of human OA and heterotopic ossification.

In vivo:

Nat Rev Rheumatol. 2012 Jun 29;8(7):369.

Osteoarthritis: Procyanidin B3 prevents OA in vivo.[Pubmed: 22744145]

Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
原花青素; Proanthocyanidins	CFN99556	4852-22-6	C₃₀H₂₆O₁₃ = 594.52	20mg	QQ客服：1457312923
原花青素B2; Procyanidin B2	CFN99558	29106-49-8	C₃₀H₂₆O₁₂ = 578.52	20mg	QQ客服：1413575084
原花青素B1; Procyanidin B1	CFN99557	20315-25-7	C₃₀H₂₆O₁₂ = 578.52	20mg	QQ客服：1457312923
原花青素B3; Procyanidin B3	CFN99559	23567-23-9	C₃₀H₂₆O₁₂ = 578.52	10mg	QQ客服：1457312923
原花青素B4; Procyanidin B4	CFN91171	29106-51-2	C₃₀H₂₆O₁₂ = 578.5	10mg	QQ客服：1457312923
Afzelechin-(4alpha->8)-epiafzelechin; Afzelechin-(4alpha->8)-epiafzelechin	CFN89432	1383627-30-2	C₃₀H₂₆O₁₀ = 546.52	5mg	QQ客服：2159513211
Cinchonain IIb; Cinchonain IIb	CFN89461	85022-68-0	C₃₉H₃₂O₁₅ = 740.66	5mg	QQ客服：1413575084
Cinchonain IIa; Cinchonain IIa	CFN89439	85081-23-8	C₃₉H₃₂O₁₅ = 740.66	5mg	QQ客服：2056216494
原花青素C1; Procyanidin C1	CFN99560	37064-30-5	C₄₅H₃₈O₁₈ = 866.77	10mg	QQ客服：2056216494
Daphnodorin B; Daphnodorin B	CFN92959	95733-02-1	C₃₀H₂₂O₁₀ = 542.49	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7285 mL	8.6427 mL	17.2855 mL	34.571 mL	43.2137 mL
5 mM	0.3457 mL	1.7285 mL	3.4571 mL	6.9142 mL	8.6427 mL
10 mM	0.1729 mL	0.8643 mL	1.7285 mL	3.4571 mL	4.3214 mL
50 mM	0.0346 mL	0.1729 mL	0.3457 mL	0.6914 mL	0.8643 mL
100 mM	0.0173 mL	0.0864 mL	0.1729 mL	0.3457 mL	0.4321 mL

原花青素B3

Procyanidin B3

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