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  • Daphnodorin B

    Daphnodorin B

    Daphnodorin B
    产品编号 CFN92959
    CAS编号 95733-02-1
    分子式 = 分子量 C30H22O10 = 542.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Amburana cearensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Daphnodorin B CFN92959 95733-02-1 1mg QQ客服:215959384
    Daphnodorin B CFN92959 95733-02-1 5mg QQ客服:215959384
    Daphnodorin B CFN92959 95733-02-1 10mg QQ客服:215959384
    Daphnodorin B CFN92959 95733-02-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
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  • Universidade do Porto (Portugal)
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  • Shanghai University of TCM (China)
  • Massachusetts General Hospital (USA)
  • University of Queensland (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Mol Med (Berl).2018, 96(7):661-672
  • J Neuroinflammation.2020, 17(1):75.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Molecules.2020, 25(21):5091.
  • PLoS One.2018, 13(11):e0208055
  • J Nat Med.2017, 71(4):745-756
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  • Foods.2022, 12(1):136.
  • Food Funct.2024, 15(8):4262-4275.
  • Food Res Int.2018, 106:909-919
  • Molecules2022, 27(9):2992.
  • Exp Ther Med.2019, 18(6):4388-4396
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Front Pharmacol.2016, 7:460
  • Front Neurosci.2019, 13:1091
  • J Nat Prod.2015, 78(6):1339-4
  • Green Chemistry2021, ISSUE 2.
  • Molecules.2020, 25(21):5087.
  • Molecules. 2013, 18(7):7376-88
  • Molecules.2023, 28(8):3291.
  • Molecules.2019, 24(2):E343
  • ...
  • 生物活性
    Description: Daphnodorin B has antifungal, antimitotic and anti-HIV-1 activity, it induced morphological deformation of P. oryzae mycelia with MMDC values of 73.7 +/- 1.6 microM, it showed moderate activity against microtubule polymerization with IC50 values of 142 +/- 2 microM in vitro, and it moderately active against HIV-1 in vitro. Daphnodorin B shows inhibitory effects of human chymase. Daphnodorin B inhibited tumor growth and metastasis by protecting host immunocyte viability and proliferation potential, and selectively inhibiting tumor cell proliferation.
    Targets: HIV | Antifection
    In vitro:
    Phytochemistry. 2014 Oct;106:61-68.
    Phytotoxic flavonoids from roots of Stellera chamaejasme L. (Thymelaeaceae).[Pubmed: 25096753 ]
    Allelopathy, the negative effect on plants of chemicals released to the surroundings by a neighboring plant, is an important factor which contributes to the spread of some weeds in plant communities. In this field, Stellera chamaejasme L. (Thymelaeaceae) is one of the most toxic and ecologically-threatening weeds in some of the grasslands of north and west China.
    METHODS AND RESULTS:
    Bioassay-guided fractionation of root extracts of this plant led to the isolation of eight flavonoids 1-8, whose structures were elucidated by spectroscopic analysis. All compounds obtained, except 7-methoxylneochaejasmin A (4) and (+)-epiafzelechin (5), showed strong phytotoxic activity against Arabidopsis thaliana seedlings. Seedling growth was reduced by neochamaejasmin B (1), mesoneochamaejasmin A (2), chamaejasmenin C (3), genkwanol A (6), Daphnodorin B (7) and dihydroDaphnodorin B (8) with IC50 values of 6.9, 12.1, 43.2, 74.8, 7.1 and 27.3μg/mL, respectively, and all of these compounds disrupted root development. Endogenous auxin levels at the root tips of the A. thaliana DR5::GUS transgenic line were largely reduced by compounds 1, 2 and 6-8, and were increased by compound 4. Moreover, the inhibition rate of A. thaliana auxin transport mutants pin2 and aux1-7 by compounds 1-8 were all lower than the wild type (Col-0). The influence of these compounds on endogenous auxin distribution is thus proposed as a critical factor for the phytotoxic effect. Compounds 1, 2, 4 and 8 were found in soils associated with S. chamaejasme, and these flavonoids also showed phytotoxicity to Clinelymus nutans L., an associated weed of S. chamaejasme.
    CONCLUSIONS:
    These results indicated that some phytotoxic compounds from roots of S. chamaejasme may be involved in the potential allelopathic behavior of this widespread weed.
    Planta Med. 2000 Aug;66(6):564-7.
    Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.[Pubmed: 10985087]

    METHODS AND RESULTS:
    With guidance of Pyricularia oryzae bioassay, daphnoretin (1), (+)-nortrachelogenin (2), genkwanol A (3), wikstrol A (4), wikstrol B (5) and Daphnodorin B (6) were isolated from the roots of Wikstroemia indica. Compounds 1-6 induced morphological deformation of P. oryzae mycelia with MMDC values of 68.4 +/- 1.3, 31.3 +/- 1.8, 45.8 +/- 0.5, 70.1 +/- 2.4, 52.3 +/- 0.9 and 73.7 +/- 1.6 microM, respectively. Compounds 3-6 showed moderate activity against microtubule polymerization with IC50 values of 112 +/- 4, 131 +/- 3, 184 +/- 6 and 142 +/- 2 microM in vitro, respectively. Compounds 2, 3, 5 and 6 were moderately active against HIV-1 in vitro.
    CONCLUSIONS:
    The findings of bioactivity of 1-6 support the antifungus, antimitosis and anti-HIV-1 uses for W. indica roots.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8434 mL 9.2168 mL 18.4335 mL 36.867 mL 46.0838 mL
    5 mM 0.3687 mL 1.8434 mL 3.6867 mL 7.3734 mL 9.2168 mL
    10 mM 0.1843 mL 0.9217 mL 1.8434 mL 3.6867 mL 4.6084 mL
    50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
    100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    原花青素; Proanthocyanidins CFN99556 4852-22-6 C30H26O13 = 594.52 20mg QQ客服:215959384
    原花青素B2; Procyanidin B2 CFN99558 29106-49-8 C30H26O12 = 578.52 20mg QQ客服:3257982914
    原花青素B1; Procyanidin B1 CFN99557 20315-25-7 C30H26O12 = 578.52 20mg QQ客服:1457312923
    原花青素B3; Procyanidin B3 CFN99559 23567-23-9 C30H26O12 = 578.52 10mg QQ客服:1413575084
    原花青素B4; Procyanidin B4 CFN91171 29106-51-2 C30H26O12 = 578.5 10mg QQ客服:2159513211
    Afzelechin-(4alpha->8)-epiafzelechin; Afzelechin-(4alpha->8)-epiafzelechin CFN89432 1383627-30-2 C30H26O10 = 546.52 5mg QQ客服:1457312923
    Cinchonain IIb; Cinchonain IIb CFN89461 85022-68-0 C39H32O15 = 740.66 5mg QQ客服:1413575084
    Cinchonain IIa; Cinchonain IIa CFN89439 85081-23-8 C39H32O15 = 740.66 5mg QQ客服:2159513211
    原花青素C1; Procyanidin C1 CFN99560 37064-30-5 C45H38O18 = 866.77 10mg QQ客服:2056216494
    Daphnodorin B; Daphnodorin B CFN92959 95733-02-1 C30H22O10 = 542.49 5mg QQ客服:1413575084

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