| In vitro: |
| Chinese Traditional & Herbal Drugs, 2012, 43(3):436-439. | | Chemical constituents from stem barks of Garcinia paucinervis.[Reference: WebLink] | To study the chemical constituents from the stem barks of Garcinia paucinervis and their antitumor activities.
METHODS AND RESULTS:
Chemical constituents were isolated and purified from petroleum ether extract of G.paucinervis by chromatography on silica gel,RP-18,Sephadex LH-20 column,and preparative TLC.Their structures were identified on the basis of spectroscopic analysis and chemical evidence.The antitumor activity was screened by MTT assay. Ten compounds were isolated and identified as cambogin(1),pyromeconic acid(2),β-sitosterol(3),daucosterol(4),7-prenyljacareubin(5),Parvifolixanthone A(6),formoxanthone A(7),termicalcicolanone A(8),1,3,5,6-tetrahydroxy-4-prenylxanthone(9),and isogarcinol(10).Compounds 5 and 7 showed moderate cytotoxic activity against HL-60,SMMC-7721,A549,MCF-7,and SW480 cell lines.
CONCLUSIONS:
Compounds 2—5 and 7—10 are isolated from this plant for the first time and the13C-NMR spectroscopic data of compound 5 are firstly reported. |
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