Griffipavixanthone

	产品编号	CFN98089
	CAS编号	219649-95-3
	分子式 = 分子量	C₃₆H₂₈O₁₂ = 652.6
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Xanthones
	植物来源	The fruits of Garcinia oblongifolia Champ.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Griffipavixanthone	CFN98089	219649-95-3	1mg	QQ客服：2056216494
Griffipavixanthone	CFN98089	219649-95-3	5mg	QQ客服：2056216494
Griffipavixanthone	CFN98089	219649-95-3	10mg	QQ客服：2056216494
Griffipavixanthone	CFN98089	219649-95-3	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Research Council of Canada (Canada)

University of Helsinki (Finland)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Funda??o Universitária de Desenvolvimento (Brazil)

University of Amsterdam (Netherlands)

Monash University Sunway Campus (Malaysia)

Universite de Lille1 (France)

Copenhagen University (Denmark)

University of Pretoria (South Africa)

Auburn University (USA)

Wageningen University (Netherlands)

Mendel University in Brno (Czech Republic)

Calcutta University (India)

University of Wuerzburg (Germany)

More...

Description:

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.

Targets:

ROS | Caspase | RAF | MEK | ERK

In vitro:

Molecules. 2014 Jan 27;19(2):1422-31.

Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro.[Pubmed: 24473206]

Griffipavixanthone (GPX) is a dimeric xanthone which was isolated in a systematic investigation of Garcinia oblongifolia Champ. In this study, we investigate the effect of Griffipavixanthone on cell proliferation and apoptosis on human Non-small-cell lung cancer (NSCLC) cells in vitro and determine the mechanisms of its action.
METHODS AND RESULTS:
Griffipavixanthone inhibited the growth of H520 cells in dose- and time-dependent manners, with IC50 values of 3.03 ± 0.21 μM at 48 h. In addition, Annexin V/PI double staining assay revealed that cells in early stage of apoptosis were significantly increased upon Griffipavixanthone treatment dose-dependently. Rh123 staining assay indicated that Griffipavixanthone reduced the mitochondrial membrane potential. DCFH-DA staining revealed that intracellular ROS increased with Griffipavixanthone treatment. Moreover, Griffipavixanthone cleaved and activated caspase-3.
CONCLUSIONS:
In summary, this study showed that Griffipavixanthone inhibited H520 cell proliferation in dose- and time-dependent manner. Further mechanistic study indicated that Griffipavixanthone induced cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Our results demonstrate the potential application of Griffipavixanthone as an anti-non-small cell lung cancer agent.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Parvifolixanthone A; Parvifolixanthone A	CFN89058	906794-56-7	C₂₈H₃₂O₆ = 464.55	5mg	QQ客服：1457312923
Latisxanthone C ; Latisxanthone C	CFN89046	197447-32-8	C₂₈H₃₀O₆ = 462.54	5mg	QQ客服：1413575084
Butyraxanthone B; Butyraxanthone B	CFN92696	1141754-81-5	C₂₈H₃₀O₆ = 462.5	5mg	QQ客服：1457312923
伽升沃E; Garcinone E	CFN92697	112649-21-5	C₂₈H₃₂O₆ = 464.6	5mg	QQ客服：1457312923
异藤黄氧蒽酮E; Isogarciniaxanthone E	CFN97125	659747-28-1	C₂₈H₃₂O₆ = 464.6	5mg	QQ客服：215959384
藤黄呫吨酮E; Garciniaxanthone E	CFN99816	173294-74-1	C₂₈H₃₂O₆ = 464.6	5mg	QQ客服：1413575084
柄曲霉素; Sterigmatocystin	CFN96575	10048-13-2	C₁₈H₁₂O₆ = 324.29	5mg	QQ客服：3257982914
Griffipavixanthone; Griffipavixanthone	CFN98089	219649-95-3	C₃₆H₂₈O₁₂ = 652.6	5mg	QQ客服：3257982914
Bijaponicaxanthone C; Bijaponicaxanthone C	CFN96574	872409-35-3	C₃₆H₃₀O₁₃ = 670.62	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5323 mL	7.6617 mL	15.3233 mL	30.6466 mL	38.3083 mL
5 mM	0.3065 mL	1.5323 mL	3.0647 mL	6.1293 mL	7.6617 mL
10 mM	0.1532 mL	0.7662 mL	1.5323 mL	3.0647 mL	3.8308 mL
50 mM	0.0306 mL	0.1532 mL	0.3065 mL	0.6129 mL	0.7662 mL
100 mM	0.0153 mL	0.0766 mL	0.1532 mL	0.3065 mL	0.3831 mL