伽升沃E

Garcinone E

	产品编号	CFN92697
	CAS编号	112649-21-5
	分子式 = 分子量	C₂₈H₃₂O₆ = 464.6
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Xanthones
	植物来源	The fruits of Garcinia mangostana
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
伽升沃E	CFN92697	112649-21-5	1mg	QQ客服：1457312923
伽升沃E	CFN92697	112649-21-5	5mg	QQ客服：1457312923
伽升沃E	CFN92697	112649-21-5	10mg	QQ客服：1457312923
伽升沃E	CFN92697	112649-21-5	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Heidelberg University (Germany)

University of Leipzig (Germany)

Michigan State University (USA)

National Chung Hsing University (Taiwan)

University of Lodz (Poland)

Wageningen University (Netherlands)

Centrum Menselijke Erfelijkheid (Belgium)

Universitas Airlangga (Indonesia)

Monash University (Australia)

Medical University of South Carolina (USA)

Uniwersytet Gdański (Poland)

University of Wisconsin-Madison (USA)

University of Amsterdam (Netherlands)

Lodz University of Technology (Poland)

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Description:

Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.

Targets:

Antifection

In vitro:

Planta Med. 2002 Nov;68(11):975-9.

Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.[Pubmed: 12451486]

Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs.
METHODS AND RESULTS:
We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs.
CONCLUSIONS:
Our results have shown that one of the xanthone derivatives which could be identified as Garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that Garcinone E may be potentially useful for the treatment of certain types of cancer.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Parvifolixanthone A; Parvifolixanthone A	CFN89058	906794-56-7	C₂₈H₃₂O₆ = 464.55	5mg	QQ客服：2159513211
Latisxanthone C ; Latisxanthone C	CFN89046	197447-32-8	C₂₈H₃₀O₆ = 462.54	5mg	QQ客服：215959384
Butyraxanthone B; Butyraxanthone B	CFN92696	1141754-81-5	C₂₈H₃₀O₆ = 462.5	5mg	QQ客服：1413575084
伽升沃E; Garcinone E	CFN92697	112649-21-5	C₂₈H₃₂O₆ = 464.6	5mg	QQ客服：215959384
异藤黄氧蒽酮E; Isogarciniaxanthone E	CFN97125	659747-28-1	C₂₈H₃₂O₆ = 464.6	5mg	QQ客服：215959384
藤黄呫吨酮E; Garciniaxanthone E	CFN99816	173294-74-1	C₂₈H₃₂O₆ = 464.6	5mg	QQ客服：1413575084
柄曲霉素; Sterigmatocystin	CFN96575	10048-13-2	C₁₈H₁₂O₆ = 324.29	5mg	QQ客服：1457312923
Griffipavixanthone; Griffipavixanthone	CFN98089	219649-95-3	C₃₆H₂₈O₁₂ = 652.6	5mg	QQ客服：1457312923
Bijaponicaxanthone C; Bijaponicaxanthone C	CFN96574	872409-35-3	C₃₆H₃₀O₁₃ = 670.62	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1524 mL	10.7619 mL	21.5239 mL	43.0478 mL	53.8097 mL
5 mM	0.4305 mL	2.1524 mL	4.3048 mL	8.6096 mL	10.7619 mL
10 mM	0.2152 mL	1.0762 mL	2.1524 mL	4.3048 mL	5.381 mL
50 mM	0.043 mL	0.2152 mL	0.4305 mL	0.861 mL	1.0762 mL
100 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.4305 mL	0.5381 mL