三七皂苷T5

Notoginsenoside T5

	产品编号	CFN92824
	CAS编号	769932-34-5
	分子式 = 分子量	C₄₁H₆₈O₁₂ = 753.0
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Panax notoginseng (Burk.)F.H.Chen
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
三七皂苷T5	CFN92824	769932-34-5	1mg	QQ客服：1413575084
三七皂苷T5	CFN92824	769932-34-5	5mg	QQ客服：1413575084
三七皂苷T5	CFN92824	769932-34-5	10mg	QQ客服：1413575084
三七皂苷T5	CFN92824	769932-34-5	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Charles University in Prague (Czech Republic)

University of Perugia (Italy)

Institute of Chinese Materia Medica (China)

Georgia Institute of Technology (USA)

Srinakharinwirot University (Thailand)

Medizinische Universit?t Wien (Austria)

University of Otago (New Zealand)

Utrecht University (Netherlands)

Universidad de La Salle (Mexico)

University of Wisconsin-Madison (USA)

University of Oslo (Norway)

Ateneo de Manila University (Philippines)

Imperial College London (United Kingdom)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

More...

Description:

Total panax notoginsenosides (TPNS) are the main active ingredients in San-Chi, the root of(Burk) F.H. Chen, which belongs to the Araliaceae family and has been used in traditional Chinese medicine to treat atherosclerosis;TPNS can prevent atherosclerosis by lowering serum lipid levels and regulating vascular CD40 and MMP-9 expression, TPNS may have implications for clinical treatment of atherosclerosis vascular disease.

Targets:

MMP(e.g.TIMP)

In vitro:

J Ginseng Res . 2018 Jul;42(3):270-276.

Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng[Pubmed: 29983608]

Abstract Background: Notoginsenoside Ft1 is a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultralow utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1. Methods: Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS (UHPLC-MS/MS). Results and conclusion: Notoginsenoside Ft1 was epimerized from notoginsenoside ST4, which was generated through cleaving the carbohydrate side chains at C-20 of notoginsenosides Fa and Fc, and vina-ginsenoside R7, and further converted to other compounds via hydroxylation at C-25 or hydrolysis of the carbohydrate side chains at C-3 under the acid conditions. High temperature contributed to the hydroxylation reaction at C-25 and 25% acetic acid concentration was conducive to the preparation of notoginsenoside Ft1. C-20 epimers of notoginsenoside Ft1 and ST4 were successfully separated utilizing solvent method of acetic acid solution. The theoretical preparation yield rate of notoginsenoside Ft1 was about 1.8%, which would be beneficial to further study on its bioactivities and clinical application.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
20(R)-三七皂苷 R2; 20(R)-Notoginsenoside R2	CFN93373	948046-15-9	C₄₁H₇₀O₁₃ = 771.0	5mg	QQ客服：1457312923
三七皂苷T5; Notoginsenoside T5	CFN92824	769932-34-5	C₄₁H₆₈O₁₂ = 753.0	5mg	QQ客服：2159513211
人参皂苷Rg2; Ginsenoside Rg2	CFN99968	52286-74-5	C₄₂H₇₂O₁₃ = 785.02	20mg	QQ客服：2056216494
人参皂苷Rf; Ginsenoside Rf	CFN99976	52286-58-5	C₄₂H₇₂O₁₄ = 801.01	20mg	QQ客服：1413575084
20-葡萄糖人参皂苷R; 20-O-Glucoginsenoside Rf	CFN95036	68406-27-9	C₄₈H₈₂O₁₉ = 963.2	5mg	QQ客服：1457312923
(20R)-人参皂苷Rh1; (20R)-Ginsenoside Rh1	CFN92796	80952-71-2	C₃₆H₆₂O₉ = 638.9	20mg	QQ客服：3257982914
20R-人参皂苷Rg2; 20R-Ginsenoside Rg2	CFN90412	80952-72-3	C₄₂H₇₂O₁₃ = 785.02	20mg	QQ客服：1413575084
20(S)-原人参三醇; (20S)-Protopanaxatriol	CFN90564	34080-08-5	C₃₀H₅₂O₄ = 476.4	20mg	QQ客服：3257982914
人参皂苷Rh1; Ginsenoside Rh1	CFN99970	63223-86-9	C₃₆H₆₂O₉ = 638.88	20mg	QQ客服：1457312923
三七皂苷R2; Notoginsenoside R2	CFN92364	80418-25-3	C₄₁H₇₀O₁₃ = 771.0	20mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.328 mL	6.6401 mL	13.2802 mL	26.5604 mL	33.2005 mL
5 mM	0.2656 mL	1.328 mL	2.656 mL	5.3121 mL	6.6401 mL
10 mM	0.1328 mL	0.664 mL	1.328 mL	2.656 mL	3.3201 mL
50 mM	0.0266 mL	0.1328 mL	0.2656 mL	0.5312 mL	0.664 mL
100 mM	0.0133 mL	0.0664 mL	0.1328 mL	0.2656 mL	0.332 mL