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  • 20R-人参皂苷Rg2

    • 20R-人参皂苷Rg2

    20R-Ginsenoside Rg2

    20R-人参皂苷Rg2
    		产品编号 CFN90412
    CAS编号 80952-72-3
    分子式 = 分子量 C42H72O13 = 785.02
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    20R-人参皂苷Rg2 CFN90412 80952-72-3 10mg QQ客服：215959384
    20R-人参皂苷Rg2 CFN90412 80952-72-3 20mg QQ客服：215959384
    20R-人参皂苷Rg2 CFN90412 80952-72-3 50mg QQ客服：215959384
    20R-人参皂苷Rg2 CFN90412 80952-72-3 100mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Med Food.2019, 22(10):1067-1077
  • Curr Issues Mol Biol.2024, 46(4):3328-3341.
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • Phytomedicine.2021, 93:153789.
  • Front Pharmacol.2021, 12:635510.
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  • Biomed Pharmacother.2020, 128:110318.
  • Journal of Cluster Science2024, 35:635-656.
  • Mol Med Rep.2023 Oct;28(4):193.
  • Appl. Sci.2020, 10(20),7374.
  • Biochem Pharmacol. 2023, 210:115463.
  • Int J Mol Sci.2023, 25(1):162.
  • Molecules.2016, 21(6)
  • Res Rep Urol.2022, 14:313-326.
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • Molecules.2021, 26(16):4722.
  • Arch Biochem Biophys.2020, 687:108363.
  • Acta Agriculturae Scandinavica2015, 381-383
  • Toxins (Basel).2020, 12(4):210.
  • Oxid Med Cell Longev2019, 9056845:13
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  • Heliyon.2023, 9:e21652.
  • ...
    • 生物活性
    Description: Ginsenoside Rg2 may have a therapeutic potential for type 2 diabetic patients, it suppresses the hepatic glucose production via AMPK-induced phosphorylation of GSK3βand induction of SHP gene expression .Ginsenoside Rg2 can protect H9c2 cells against H2O2- induced injury through its actions of anti-oxidant and anti-apoptosis.20R-Ginsenoside Rg2 inhibits the cytokine interleukin 1 alpha (IL-1α)-induced reduction in gap junction-mediated intercellular communication (GJIC).
    Targets: GSK-3 | IL Receptor | AMPK
    In vitro:
    Planta Med., 2001, 67(5):417-22.
    Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.[Pubmed: 11488454 ]

    METHODS AND RESULTS:
    In the present study we examined the effects of 27 ginsenosides isolated from Panax ginseng on GJIC. The results show that compounds 1 (oleanolic acid), 2 (ginsenoside-R0), 3 (ginsenoside-Rb1), 5 (ginsenoside-Rb2), 7 (ginsenoside-Rd), 8 (ginsenoside-Rg3), 12 (panaxadial), 13 (notoginsenoside-R4), 17 [ginsenoside-Rg2 (20S)], 18 (ginsenoside-Rf), and 26 (ginsenoside-F3) did not obviously affect GJIC, whereas compounds 4 (ginsenoside-Rc), 6 (ginsenoside-Rb3), 9 (ginsenoside-Rd2), 10 (notoginsenoside-Fe), 11 (ginsenoside-Rh2),14 (ginsenoside-Ra1), 15 (ginsenoside-Re), 16 (20R-Ginsenoside Rg2 ), 19 (ginsenoside-Ia), 20 [ginsenoside-Rh1 (20S)], 21 [ginsenoside-Rh1 (20R)], 22 (ginsenoside-F1), 23 (protopanaxatriol), 24 (panaxatriol), 25 (ginsenoside-Rg1), and 27 (chikusetsaponin-L8) induced GJIC reductions at various degrees. Compounds 2, 7, and 8 protected against the tyrosine phosphatase inhibitor vanadate-induced GJIC reduction, while compounds 1, 5, 7, and 17 inhibited the cytokine interleukin 1 alpha (IL-1alpha)-induced reduction in GJIC. Nevertheless, no compounds protected against the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced GJIC inhibition. On the other hand, GJIC reductions induced by compounds 6, 9,10, 20, 21, 22, 24, and 25 were inhibited by the tyrosine kinase (TK) inhibitor genistein, while GJIC reductions induced by compounds 6, 9, 14, 16, 19, 21, and 24 were attenuated in the presence of the PKC inhibitor calphostin C. However, GJIC reductions induced by compounds 4, 23, and 27 were not inhibited either by genistein or by calphostin C.
    CONCLUSIONS:
    These data indicate that various mechanisms are responsible for effects of ginsenosides on GJIC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2739 mL 6.3693 mL 12.7385 mL 25.4771 mL 31.8463 mL
    5 mM 0.2548 mL 1.2739 mL 2.5477 mL 5.0954 mL 6.3693 mL
    10 mM 0.1274 mL 0.6369 mL 1.2739 mL 2.5477 mL 3.1846 mL
    50 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5095 mL 0.6369 mL
    100 mM 0.0127 mL 0.0637 mL 0.1274 mL 0.2548 mL 0.3185 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷Rh1; Ginsenoside Rh1 CFN99970 63223-86-9 C36H62O9 = 638.88 20mg QQ客服：215959384
    三七皂苷R2; Notoginsenoside R2 CFN92364 80418-25-3 C41H70O13 = 771.0 20mg QQ客服：1457312923
    20(R)-三七皂苷 R2; 20(R)-Notoginsenoside R2 CFN93373 948046-15-9 C41H70O13 = 771.0 5mg QQ客服：3257982914
    三七皂苷T5; Notoginsenoside T5 CFN92824 769932-34-5 C41H68O12 = 753.0 5mg QQ客服：1413575084
    人参皂苷Rg2; Ginsenoside Rg2 CFN99968 52286-74-5 C42H72O13 = 785.02 20mg QQ客服：2159513211
    人参皂苷Rf; Ginsenoside Rf CFN99976 52286-58-5 C42H72O14 = 801.01 20mg QQ客服：215959384
    20-葡萄糖人参皂苷R; 20-O-Glucoginsenoside Rf CFN95036 68406-27-9 C48H82O19 = 963.2 5mg QQ客服：1457312923
    (20R)-人参皂苷Rh1; (20R)-Ginsenoside Rh1 CFN92796 80952-71-2 C36H62O9 = 638.9 20mg QQ客服：215959384
    20R-人参皂苷Rg2; 20R-Ginsenoside Rg2 CFN90412 80952-72-3 C42H72O13 = 785.02 20mg QQ客服：3257982914
    20(S)-原人参三醇; (20S)-Protopanaxatriol CFN90564 34080-08-5 C30H52O4 = 476.4 20mg QQ客服：1457312923

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