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  • 异落叶松脂素 9'-beta-D-吡喃木糖苷

    Schizandriside

    异落叶松脂素 9'-beta-D-吡喃木糖苷
    产品编号 CFN96693
    CAS编号 71222-06-5
    分子式 = 分子量 C25H32O10 = 492.52
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The leaves of Miconia rubiginosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异落叶松脂素 9'-beta-D-吡喃木糖苷 CFN96693 71222-06-5 1mg QQ客服:1148253675
    异落叶松脂素 9'-beta-D-吡喃木糖苷 CFN96693 71222-06-5 5mg QQ客服:1148253675
    异落叶松脂素 9'-beta-D-吡喃木糖苷 CFN96693 71222-06-5 10mg QQ客服:1148253675
    异落叶松脂素 9'-beta-D-吡喃木糖苷 CFN96693 71222-06-5 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University Sunway Campus (Malaysia)
  • University of Oslo (Norway)
  • University of Brasilia (Brazil)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • National Hellenic Research Foundation (Greece)
  • Universidad de Antioquia (Colombia)
  • University of Wollongong (Australia)
  • Donald Danforth Plant Science Center (USA)
  • University of Hertfordshire (United Kingdom)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Maryland School of Medicine (USA)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of British Columbia (Canada)
  • Sanford Burnham Medical Research Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(6)
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Applied Biological Chemistry 2021, 64(75)
  • Molecules.2019, 24(11):E2102
  • J. Food Composition and Analysis2022, 114:104731
  • Sci Rep.2019, 9(1):18080
  • Heliyon2020, 6(6):e04337.
  • Front Pharmacol.2016, 7:460
  • Nutrients2020, 12(2):488
  • Phytother Res.2022, 35844057.
  • J Nat Prod.2017, 80(4):854-863
  • Front. Plant Sci.2022, 13:757852.
  • Sci Rep.2019, 9(1):6429
  • J Pharm Biomed Anal.2017, 140:274-280
  • South African J of Plant&Soil2018, 29-32
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • J of Ana. Chem.2019, 74(11):1113-1121
  • J Nat Prod.2018, 81(4):966-975
  • Pharmaceuticals (Basel).2021, 14(6):588.
  • The Korea Journal of Herbology2016, 29-35
  • LWT2020, 126:109313
  • Environ Toxicol.2021, doi: 10.1002
  • LWT2020, 130:109535
  • ...
  • 生物活性
    Description: Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells. It shows significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with inhibitory concentration (IC50) values of 3.26-8.89 uM.
    Targets: IFN-γ | PGE | NO
    In vitro:
    Food Chem Toxicol. 2012 Oct;50(10):3680-6.
    Lignan constituents of Tilia amurensis and their biological evaluation on antitumor and anti-inflammatory activities.[Pubmed: 22819933]
    In the recent decade, numerous lignan derivatives isolated from plants have been proven to have the potential as an anti-cancer substance.
    METHODS AND RESULTS:
    On the search for anti-cancer compounds from Korean medicinal plants, the methanolic extract from the trunk of Tilia amurensis Rupr. (Tiliaceae) was found to have significant cytotoxicity against A549 (lung carcinoma), SK-OV-3 (ovary malignant ascites), SK-MEL-2 (skin melanoma), and HCT-15 (colon adenocarcinoma) in our screening test. Hence, a bioassay-guided fractionation and chemical investigation of the methanolic extract resulted in the isolation and identification of 10 lignan derivatives (1-10) including two new lignan glycosides named tiliamurosides A (1) and B (2). The structures of these new compounds were determined by spectroscopic methods, namely 1D and 2D nuclear magnetic resonance (NMR) techniques, high resolution mass spectrometry (HRMS), circular dichroism (CD) data, and chemical methods.
    CONCLUSIONS:
    Tiliamuroside B (2) and schizandriside (3) showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with inhibitory concentration (IC50) values of 3.26-8.89 μM. Moreover, (-)-syringaresinol (8) and (-)-pinoresinol 4-O-β-D-glucopyranoside (10) significantly inhibited nitric oxide (NO) production in murine microglia BV-2 with IC50 values of 15.05 and 34.35 μM, respectively.
    Arch Pharm Res. 2010 Dec;33(12):2011-6.
    Inhibitory effects of phenolic compounds from needles of Pinus densiflora on nitric oxide and PGE2 production.[Pubmed: 21191767 ]
    The needles of Pinus densiflora Siebold et Zuccarini, a representative Pinus species that grows in Korea, have been used in oriental traditional medicine as remedies for rheumatitis, hemorrhage, cancer, etc.
    METHODS AND RESULTS:
    Phytochemical examination of the needles of Pinus densiflora Siebold et Zuccarini led to the isolation of four lignans, one flavan-3-ol, two flavonols and one organic acid. They were identified as icariside E(4) (1), cupressoside A (2), schizandriside (3), (+)-isolariciresinol (4), (+)-catechin (5), quercetin 3-O-β-D-glucopyranoside (6), 5,7,8,4'-tetrahydroxy-3-methoxy-6-methylflavone 8-O-β-D-glucopyranoside (7) and (-)-shikimic acid (8).
    CONCLUSIONS:
    In order to evaluate the anti-inflammatory effects of these compounds, their inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells were examined.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0304 mL 10.1519 mL 20.3037 mL 40.6075 mL 50.7594 mL
    5 mM 0.4061 mL 2.0304 mL 4.0607 mL 8.1215 mL 10.1519 mL
    10 mM 0.203 mL 1.0152 mL 2.0304 mL 4.0607 mL 5.0759 mL
    50 mM 0.0406 mL 0.203 mL 0.4061 mL 0.8121 mL 1.0152 mL
    100 mM 0.0203 mL 0.1015 mL 0.203 mL 0.4061 mL 0.5076 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异橄榄树脂素; Cycloolivil CFN96185 3064-05-9 C20H24O7 = 376.4 5mg QQ客服:2932563308
    异落叶松脂素; Isolariciresinol CFN98915 548-29-8 C20H24O6 = 360.4 5mg QQ客服:215959384
    9,9'-O-Isopropyllidene-isolariciresinol; 9,9'-O-Isopropyllidene-isolariciresinol CFN98276 252333-71-4 C23H28O6 = 400.5 5mg QQ客服:3257982914
    异落叶松脂素 9'-beta-D-吡喃木糖苷; Schizandriside CFN96693 71222-06-5 C25H32O10 = 492.52 5mg QQ客服:2932563308
    (-)-异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-Isolariciresinol 9'-O-glucoside CFN89431 143236-04-8 C26H34O11 = 522.54 5mg QQ客服:1413575084
    Vitexdoin A; Vitexdoin A CFN96194 1186021-77-1 C19H18O6 = 342.4 5mg QQ客服:215959384
    7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol CFN99605 145918-59-8 C20H20O6 = 356.4 5mg QQ客服:1148253675
    Vitedoin A; Vitedoin A CFN96448 819861-40-0 C20H20O6 = 356.37 5mg QQ客服:1148253675
    (-)-5'-甲氧基异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside CFN95403 143236-03-7 C27H36O12 = 552.6 5mg QQ客服:3257982914
    (+)-南烛木树脂酚; (+)-Lyoniresinol CFN99488 14464-90-5 C22H28O8 = 420.5 5mg QQ客服:215959384

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