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  • 木犀草素-7-O-葡萄糖醛酸苷

    Luteolin-7-O-glucuronide

    木犀草素-7-O-葡萄糖醛酸苷
    产品编号 CFN98512
    CAS编号 29741-10-4
    分子式 = 分子量 C21H18O12 = 462.36
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Marchantia berteroana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木犀草素-7-O-葡萄糖醛酸苷 CFN98512 29741-10-4 10mg QQ客服:1457312923
    木犀草素-7-O-葡萄糖醛酸苷 CFN98512 29741-10-4 20mg QQ客服:1457312923
    木犀草素-7-O-葡萄糖醛酸苷 CFN98512 29741-10-4 50mg QQ客服:1457312923
    木犀草素-7-O-葡萄糖醛酸苷 CFN98512 29741-10-4 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mahatma Gandhi University (India)
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  • Michigan State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2018, 18(1):303
  • Antioxidants (Basel).2020, 9(6):526.
  • Int J Mol Sci.2024, 25(5):2799.
  • Environ Toxicol.2024, 39(3):1556-1566.
  • Horticulture Research2022, uhac276.
  • Food Chem Toxicol.2023, 176:113802.
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • J Ethnopharmacol.2023, 317:116789.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • South African J of Botany2020, 135:50-57
  • Journal of Functional Foods2022, 96: 105216.
  • Journal of Ginseng Research2021, 25 November
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • Sci Rep.2018, 8(1):12970
  • Appl. Sci.2020, 10(20), 7323.
  • J Pain Res.2022, 15:3469-3478.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Molecules.2021, 26(4):817.
  • The Thai Journal of Pharmaceutical Sciences2023, 47(3):3.
  • Food Chem.2021, 377:131976.
  • Molecules.2024, 29(5):1048.
  • Int J Oncol.2016, 49(4):1497-504
  • ...
  • 生物活性
    Description: Luteolin-7-O-glucuronide has anti-inflammatory activity. Luteolin 7-O-glucuronide shows potent α-glucosidase inhibitory effect with IC50 values of 14.7 uM, it also exhibits moderate α-amylase activity with IC50 values 61.5uM.Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.
    Targets: NOS | COX | ROS | NO | α-glucosidase | α-amylase | MMP-1 | MMP-3 | MMP-8 | MMP-9 | MMP-13
    In vitro:
    J Med Food. 2015 Jan;18(1):83-94.
    Quantification of major compounds from Ixeris dentata, Ixeris dentata Var. albiflora, and Ixeris sonchifolia and their comparative anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells.[Pubmed: 25383596]
    The aim of the present study was to evaluate the comparative anti-inflammatory activities of Ixeris dentata (ID), Ixeris dentata var. albiflora (IDA), and Ixeris sonchifolia (IS) and to identify the main compounds present in extracts. The anti-inflammatory activity was evaluated through lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 murine macrophages. Five main compounds consisting of chlorogenic acid, caffeic acid, luteolin-7-O-glucoside, Luteolin-7-O-glucuronide, and luteolin were used for simultaneous high-performance liquid chromatography quantification.
    METHODS AND RESULTS:
    The total phenolic content present in ID (30 mg/g GAE), IDA (35.33 mg/g GAE), and IS (43.79 mg/g GAE) was correlated to the corresponding LPS-induced NO production inhibitory effect in RAW 264.7 cells as expressed with IC(50) values 26.19, 21.43, and 7.59 μg/mL, respectively. Luteolin-7-O-glucoside was found as the major compound in ID (8.76 mg/g dry weight) and IDA (10.35 mg/g dry weight) and Luteolin-7-O-glucuronide was the major compound in IS (34.66 mg/g dry weight). Luteolin 7-O-glucoside and Luteolin-7-O-glucuronide inhibited LPS-induced NO production with IC(50) values of 30 and 4.5 μM, respectively. Furthermore, luteolin, luteolin-7-O-glucoside, and luteolin- 7-O-glucuronide suppressed the expression of iNOS and COX-2, and t-BHP-induced ROS generation in LPS-stimulated RAW 264.7 cells.
    CONCLUSIONS:
    These results clearly showed that the anti-inflammatory potential of ID, IDA, and IS extract are primarily due to their contents of luteolin-7-O-glucoside and Luteolin-7-O-glucuronide, respectively.
    Planta Med. 2017 Jul;83(11):901-911.
    Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids.[Pubmed: 28288492 ]
    Metalloproteases are a family of zinc-containing endopeptidases involved in a variety of pathological disorders. The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).
    METHODS AND RESULTS:
    The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking.The flavones apigenin, luteolin, and their respective glucosides have good ability to interact with metalloproteases and can also be lead compounds for further development. Glycones are more active on MMP-1, -3, -8, and -13 than MMP-9. Collagenases MMP-1, MMP-8, and MMP-13 are inhibited by compounds having rutinoside glycones. Apigenin and luteolin are inactive on MMP-1, -3, and -8, which can be interpreted as a better selectivity for both -9 and -13 peptidases. The more active compounds are apigenin-7-O-rutinoside on MMP-1 and luteolin-7-O-rutinoside on MMP-3. The lowest IC50 values were also found for apigenin-7-O-glucuronide, apigenin-7-O-rutinoside, and luteolin-7-O-glucuronide. The glycoside moiety might allow for a better anchoring to the active site of MMP-1, -3, -8, -9, and -13.
    CONCLUSIONS:
    Overall, the in silico data are substantially in agreement with the in vitro ones (fluorimetric assay).
    In vivo:
    J Agric Food Chem. 2014 Jun 11;62(23):5290-5.
    Bioavailability of hydroxycinnamic acids from Crepidiastrum denticulatum using simulated digestion and Caco-2 intestinal cells.[Pubmed: 24841645]
    Hydroxycinnamic acids have antioxidant properties and potentially beneficial effects on human health. This study investigated the digestive stability, bioaccessibility, and permeability of hydroxycinnamic acids from Crepidiastrum denticulatum using simulated digestion and Caco-2 intestinal cells.
    METHODS AND RESULTS:
    The major compounds of C. denticulatum were determined to be four hydroxycinnamic acids [caftaric acid, chlorogenic acid, chicoric acid, and 3,5-di-O-caffeoylquinic acid (3,5-DCQA)] and one flavonoid (luteolin-7-O-glucuronide) by high-performance liquid chromatography and electrospray ionization mass spectrometry. Hydroxycinnamic acids from C. denticulatum were rapidly released in the stomach and duodenum phase, maximizing the possibility of absorption in the intestinal Caco-2 cells. The digestive stability and bioaccessibility of hydroxycinnamic acids from C. denticulatum were markedly low after simulated digestion and remained minimal in the soluble fraction of the ileum phase. Unlike the four hydroxycinnamic acids, luteolin-7-O-glucuronide was stable in terms of digestive stability and bioaccessibility during simulated digestion. The cell permeabilities (P(app A to B)/P(app B to A)) of caftaric acid (0.054) and chlorogenic acid (0.055) were higher than those of chicoric acid (0.011) and 3,5-DCQA (0.006) in general. That of luteolin-7-O-glucuronide was not detectable, showing its low absorption in Caco-2 cells.
    CONCLUSIONS:
    These results indicate that the rapid release of hydroxycinnamic acids in the stomach and duodenum phase may increase the potential for absorption in Caco-2 cells, and that luteolin-7-O-glucuronide, which was stable in terms of digestive stability and bioaccessibility, has relatively low absorption compared with hydroxycinnamic acids.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1628 mL 10.8141 mL 21.6282 mL 43.2563 mL 54.0704 mL
    5 mM 0.4326 mL 2.1628 mL 4.3256 mL 8.6513 mL 10.8141 mL
    10 mM 0.2163 mL 1.0814 mL 2.1628 mL 4.3256 mL 5.407 mL
    50 mM 0.0433 mL 0.2163 mL 0.4326 mL 0.8651 mL 1.0814 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4326 mL 0.5407 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木犀草苷; 木犀草素-7-O-葡萄糖苷; Luteolin-7-O-glucoside CFN98565 5373-11-5 C21H20O11 = 448.38 20mg QQ客服:1413575084
    木犀草素-7-O-葡萄糖醛酸苷; Luteolin-7-O-glucuronide CFN98512 29741-10-4 C21H18O12 = 462.36 20mg QQ客服:2056216494
    忍冬苷; Lonicerin CFN95055 25694-72-8 C27H30O15 = 594.5 10mg QQ客服:215959384
    木犀草素 7-芸香糖苷; Luteolin 7-rutinoside CFN93556 20633-84-5 C27H30O15 = 594.52 20mg QQ客服:1413575084
    木犀草素 5-葡萄糖苷; Luteollin 5-glucoside CFN98568 20344-46-1 C21H20O11 = 448.38 5mg QQ客服:2056216494
    芫花叶苷; Yuanhuanin CFN95127 83133-14-6 C22H22O11 = 462.4 5mg QQ客服:2056216494
    芫花素-5-O-茜黄苷; Yuankanin CFN95128 77099-20-8 C27H30O14 = 578.5 5mg QQ客服:2056216494
    木犀草素-3'-葡萄糖醛酸苷; Luteolin-3-O-beta-D-glucuronide CFN93187 53527-42-7 C21H18O12 = 462.4 10mg QQ客服:2159513211
    木犀草素-7-二葡萄糖苷酸; Luteolin 7-diglucuronide CFN70468 96400-45-2 C27H26O18 = 638.5 5mg QQ客服:2159513211
    新化合物11; New compound 11 CFN95351 N/A C36H32O20 = 784.6 10mg QQ客服:1413575084

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