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  • 柯伊利素-7-O-葡萄糖苷

    Chrysoeriol-7-O-glucoside

    柯伊利素-7-O-葡萄糖苷
    产品编号 CFN93021
    CAS编号 19993-32-9
    分子式 = 分子量 C22H22O11 = 462.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Eminium spiculatum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柯伊利素-7-O-葡萄糖苷 CFN93021 19993-32-9 1mg QQ客服:1413575084
    柯伊利素-7-O-葡萄糖苷 CFN93021 19993-32-9 5mg QQ客服:1413575084
    柯伊利素-7-O-葡萄糖苷 CFN93021 19993-32-9 10mg QQ客服:1413575084
    柯伊利素-7-O-葡萄糖苷 CFN93021 19993-32-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Buenos Aires (Argentina)
  • Semmelweis Unicersity (Hungary)
  • Universitas Airlangga (Indonesia)
  • Max Rubner-Institut (MRI) (Germany)
  • University of the Basque Country (Spain)
  • MTT Agrifood Research Finland (Finland)
  • Mahatma Gandhi University (India)
  • Vin?a Institute of Nuclear Sciences (Serbia)
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  • Guangzhou Institutes of Biomedicine and Health (China)
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  • Rio de Janeiro State University (Brazil)
  • National Research Council of Canada (Canada)
  • Auburn University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Oncol Rep.2016, 35(3):1356-64
  • Saudi Pharm J.2019, 27(1):145-153
  • Antioxidants.2022, 11(4), 67.
  • APMIS.2019, 127(10):688-695
  • Int J Mol Sci.2015, 16(1):1232-51
  • Genes Genomics.2020, 10.1007
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Horticulturae2022, 8(10), 975.
  • Research Square2022, rs.3.rs-1948239
  • J Ethnopharmacol.2016, 192:370-381
  • Food Funct.2022, 13(23):12105-12120.
  • PLoS One.2017, 12(3):e0173585
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Preprints2022, 202211.0388.v1.
  • Nutrients.2018, 11(1):E17
  • Research Square2021, 10.21203.
  • Cell.2022, 185(23):4298-4316.e21.
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Aquaculture2017, 481:94-102
  • Anticancer Res.2018, 38(4):2127-2135
  • Journal of Apicultural Research2021, 60(1)
  • ...
  • 生物活性
    Description: Chrysoeriol-7-O-glucoside can strongly inhibit the classical pathway of the complement system.Chrysoeriol-7-O-d-glucoside and luteolin-7-O-d-glucoside can inhibit palmitic acid uptake into small intestinal brush border membrane, apigenin-7-O-d-glucoside can inhibit alpha-amylase activity; they can enhance norepinephrine-induced lipolysis in fat cells.
    In vitro:
    J Agric Food Chem . 2019 May 1;67(17):4967-4975.
    Safety Assessment of Phytochemicals Derived from the Globalized South African Rooibos Tea ( Aspalathus linearis) through Interaction with CYP, PXR, and P-gp[Pubmed: 30955332]
    Abstract Rooibos tea ( Aspalathus linearis) is a well-known South African herbal tea enjoyed worldwide. Limited reports indicate the potential of rooibos tea to alter the activity of certain cytochrome P450 (CYP450) isozymes. In this study, the phytochemical investigation of MeOH extract of A. linearis (leaves and stems) resulted in the isolation and characterization of 11 phenolic compounds. The MeOH extract exhibited significant inhibition of the major human CYP450 isozymes (CYP3A4, CYP1A2, CYP2D6, CYP2C9, and CYP2C19). The strongest inhibition was observed by the extract for CYP3A4 (IC50 1.7 ± 0.1 μg/mL) followed by CYP2C19 (IC50 4.0 ± 0.3 μg/mL). Among the tested phytochemicals, the most potent inhibitors were isovitexin on CYP3A4 (IC50 3.4 ± 0.2 μM), vitexin on CYP2C9 (IC50 8.0 ± 0.2 μM), and thermopsoside on CYP2C19 (IC50 9.5 ± 0.2 μM). The two major, structurally related compounds aspalathin and nothofagin exhibited a moderate pregnane-X receptor (PXR) activation, which was associated with increased mRNA expression of CYP3A4 and CYP1A2, respectively. These results indicate that a high intake of nutraceuticals containing rooibos extracts may pose a risk of herb-drug interactions when consumed concomitantly with clinical drugs that are substrates of CYP enzymes. Keywords: Aspalathus linearis; CYP450; aspalathin; flavonoids; rooibos.
    In vivo:
    Phytother. Res., 2003, 17(10):1195–8.
    Anti-obesity action of Salix matsudana leaves (Part 2). Isolation of anti-obesity effectors from polyphenol fractions of Salix matsudana.[Pubmed: 14669255 ]

    METHODS AND RESULTS:
    Previously, it was reported that polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. Moreover, body weights at 2-9 weeks and the fi nal parametrial adipose tissue weights were significantly lower in mice fed the high-fat diet with 5% polyphenol fractions of S. matsudana leaves than in those fed the high-fat diet alone. The polyphenol fractions of S. matsudana leaves also significantly reduced the hepatic total cholesterol content, which was elevated in mice fed the high-fat diet alone. In addition, the polyphenol fractions of S. matsudana leaves inhibited palmitic acid uptake into brush border membrane vesicles prepared from rat jejunum and alpha-amylase activity, and their fractions enhanced norepinephrine-induced lipolysis in fat cells. To clarify the active substances inhibiting the palmitic acid uptake into small intestinal brush border membrane, the alpha-amylase activity or enhancing the norepinephrine-induced lipolyis in fat cells, the isolation of the active substances from polyphenol fraction was attempted using the above three assay systems. Compounds 1, 2 and 3 were isolated from the polyphenol fractions and identified as apigenin-7-O-d-glucoside, luteolin-7-O-d-glucoside and chrysoeriol-7-O-d-glucoside, respectively.
    CONCLUSIONS:
    Among three flavonoids, apigenin-7-O-d-glucoside inhibited alpha-amylase activity, and luteolin-7-O-d-glucoside and chrysoeriol-7-O-d-glucoside(Chrysoeriol-7-O-glucoside) inhibited palmitic acid uptake into small intestinal brush border membrane. Furthermore, three flavonoid glucosides enhanced norepinephrine-induced lipolysis in fat cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1626 mL 10.8131 mL 21.6263 mL 43.2526 mL 54.0657 mL
    5 mM 0.4325 mL 2.1626 mL 4.3253 mL 8.6505 mL 10.8131 mL
    10 mM 0.2163 mL 1.0813 mL 2.1626 mL 4.3253 mL 5.4066 mL
    50 mM 0.0433 mL 0.2163 mL 0.4325 mL 0.8651 mL 1.0813 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4325 mL 0.5407 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    假荆芥属苷; Nepetin-7-glucoside CFN90438 569-90-4 C22H22O12 = 478.40 20mg QQ客服:2056216494
    万寿菊苷; Patulitrin CFN95153 19833-25-1 C22H22O13 = 494.4 10mg QQ客服:1413575084
    槲皮万寿菊素 3-甲氧基 7-葡萄糖苷; Quercetagetin 3-methyl ether 7-glucoside CFN95632 76060-29-2 C22H22O13 = 494.4 5mg QQ客服:2159513211
    柯伊利素-7-O-葡萄糖苷; Chrysoeriol-7-O-glucoside CFN93021 19993-32-9 C22H22O11 = 462.4 5mg QQ客服:2159513211
    香叶木素7-O-beta-D-葡萄糖苷; Diosmetin-7-O-beta-D-glucopyranoside CFN98502 20126-59-4 C22H22O11 = 462.41 20mg QQ客服:1413575084
    地奥司明; Diosmin CFN98145 520-27-4 C28H32O15 = 608.54 20mg QQ客服:2056216494
    新地奥司明; Neodiosmin CFN93075 38665-01-9 C28H32O15 = 608.54 20mg QQ客服:2056216494
    Lethedoside A; Lethedoside A CFN98100 221289-20-9 C24H26O11 = 490.5 5mg QQ客服:3257982914
    Lethedioside A; Lethedioside A CFN98201 221289-31-2 C29H34O15 = 622.6 5mg QQ客服:2056216494
    5-羟基-7,8,2',5'-四甲氧基黄酮 5-O-葡萄糖苷; 5-Hydroxy-7,8,2',5'-tetramethoxyflavone 5-O-glucoside CFN97595 942626-75-7 C25H28O12 = 520.49 5mg QQ客服:215959384

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