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  • 地奥司明

    Diosmin

    地奥司明
    产品编号 CFN98145
    CAS编号 520-27-4
    分子式 = 分子量 C28H32O15 = 608.54
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Scrophularia nodosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    地奥司明 CFN98145 520-27-4 10mg QQ客服:2056216494
    地奥司明 CFN98145 520-27-4 20mg QQ客服:2056216494
    地奥司明 CFN98145 520-27-4 50mg QQ客服:2056216494
    地奥司明 CFN98145 520-27-4 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • FORTH-IMBB (Greece)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Chulalongkorn University (Thailand)
  • Imperial College London (United Kingdom)
  • University of Ioannina (Greece)
  • Universitas islam negeri Jakarta (Indonesia)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of East Anglia (United Kingdom)
  • The University of Newcastle (Australia)
  • University of Cincinnati (USA)
  • Complutense University of Madrid (Spain)
  • Universidad Industrial de Santander (Colombia)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Medicina (Kaunas).2020, 56(12):685.
  • Eur J Pharm Sci.2016, 94:33-45
  • QASCF2022, 14(4).
  • LWT-Food Science and Technology2017, 75:488-496
  • Metabolites.2023, 13(5):625.
  • Journal of Phytopathology2021, 169,Issue11-12.
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • Horticulture Research2023, uhad164.
  • BMC Complement Altern Med.2016, 16:213
  • Int J Mol Sci.2021, 22(2):770.
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • Chemistry of Natural Compounds2018, 204-206
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Nutr Cancer.2022, 1-13.
  • Chemistry of Plant Materials.2016, 33-46
  • Nutrients2020, 12(2):488
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Toxicol Rep.2021, 8:1131-1142.
  • US20170000760 A12016, 42740
  • Nutrients.2022, 14(23):4997.
  • Int Immunopharmacol.2022, 106:108603.
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Research Square2021, 10.21203.
  • ...
  • 生物活性
    Description: Diosmin is a semisynthetic phlebotropic agent, and also an agonist of the aryl hydrocarbon receptor (AhR). Diosmin can prevent the progression of early diabetic neuropathy in rats, it has cardioprotective effect by the free radical scavenging and anti-hyperlipidaemic effects .
    Targets: Bcl-2/Bax | HMG-CoA Reductase
    In vitro:
    Int J Pharm. 2014 Oct 1;473(1-2):407-13.
    Electrospinning of diosmin from aqueous solutions for improved dissolution and oral absorption.[Pubmed: 25066074]
    A nanofibrous membrane carrier for nearly water insoluble drug diosmin was formulated. The aim of this study was to evaluate the drug release and dissolution properties in an aqueous buffer of pH 7.8, and to compare the suitability of the drug carrier with the available drug forms and screen diosmin absorption extent.
    METHODS AND RESULTS:
    The membranes were produced from HPC/PVA/PEO-drug water solutions and then evaluated by SEM and DSC measurements. The results showed that diosmin was incorporated within the nanofibers in an amorphous state, and/or as a solid dispersion. The results of in vitro release experiments excerpt a very fast release of the drug, followed by the formation of an over saturated solution and partial precipitation of the drug (a "spring" effect). The enormous increases in dissolution of the drug from a nanofibrous carrier, compared to a micronized and crystalline form, was achieved. The in vivo bioavailability study carried out on rats showed higher initial drug plasma levels and higher AUC values after administration of the nanofibrous drug formulation, compared to the micronized form.
    CONCLUSIONS:
    The results of the study demonstrated that the improvement of the diosmin in vitro dissolution also brought the enhanced in vivo absorption extent of the drug.
    In vivo:
    Eur J Pharmacol. 2014 Aug 5;736:131-7.
    Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion.[Pubmed: 24769512]
    Reperfusion of ischemic tissue leads to the generation of oxygen derived free radicals which plays an important role in cellular damage. Objective of the current study is to evaluate the cardio-protective and antioxidant effect of diosmin on ischemia-reperfusion related cardiac dysfunction, oxidative stress and apoptosis.
    METHODS AND RESULTS:
    Diosmin (50 and 100 mg/kg body weight (bw)) was given every day to the rats orally throughout the experimental period. Ischemia/reperfusion protocol was carried out ex vivo using langendorff perfusion method and the cardiac functional recovery was assessed in terms of percentage rate pressure product. Coronary effluents of LDH and CK-MB activities, antioxidant enzyme activities, lipid peroxidation products, activity of TCA cycle enzymes were evaluated. Moreover, in vitro superoxide anion and hydroxyl radical scavenging potential of diosmin was also quantified. Finally, quantitative real-time PCR was used for assessing Bcl-2 mRNA expression in heart. Cardiac functional recovery was impaired after reperfusion compared with continuously perfused heart. It was significantly prevented by diosmin treatment. Impaired antioxidant enzyme activities and elevated lipid peroxidation products level were also significantly suppressed. The activity of TCA cycle enzymes was protected against reperfusion stress. Down regulated Bcl-2 was also significantly increased.
    METHODS AND RESULTS:
    This study concluded that diosmin pretreatment prevents all the impaired patterns including cardiac function, oxidative stress and apoptosis associated with reperfusion in control heart by its antioxidant role.
    Eur J Pharmacol. 2013 Oct 15;718(1-3):213-8.
    Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats.[Pubmed: 24036254]
    The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats.
    METHODS AND RESULTS:
    Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of 24h for 2 days (on 11th and 12th day). Isoproterenol-induced myocardial infarcted rats showed significant changes in electrocardiogram and an increase in the levels of cardiac markers, compared with normal rats. Additionally, increased plasma lipid peroxidation products and altered lipid metabolism in the plasma were observed in the isoproterenol-induced myocardial infarcted rats. Pretreatment with diosmin (5 and 10mg/kg body weight) minimized the electrocardiographic changes, decreased the levels of serum cardiac marker enzymes reduced plasma lipid peroxidation and minimized the alterations in the lipid metabolism of isoproterenol-induced myocardial infarcted rats. Also, diosmin inhibited the enhanced activity of liver HMG CoA reductase.
    CONCLUSIONS:
    The in vitro study revealed the free radical scavenging activity of diosmin. The free radical scavenging and anti-hyperlipidaemic effects are the reasons for the cardioprotective effects of diosmin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6433 mL 8.2164 mL 16.4328 mL 32.8655 mL 41.0819 mL
    5 mM 0.3287 mL 1.6433 mL 3.2866 mL 6.5731 mL 8.2164 mL
    10 mM 0.1643 mL 0.8216 mL 1.6433 mL 3.2866 mL 4.1082 mL
    50 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.6573 mL 0.8216 mL
    100 mM 0.0164 mL 0.0822 mL 0.1643 mL 0.3287 mL 0.4108 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木犀草素-7-二葡萄糖苷酸; Luteolin 7-diglucuronide CFN70468 96400-45-2 C27H26O18 = 638.5 5mg QQ客服:2056216494
    新化合物11; New compound 11 CFN95351 N/A C36H32O20 = 784.6 10mg QQ客服:1413575084
    木樨草素 7,3'-二-O-葡糖醛酸苷; Luteolin 7,3'-di-O-glucuronide CFN98573 53965-08-5 C27H26O18 = 638.48 5mg QQ客服:2056216494
    6-羟基木犀草苷; 6-Hydroxyluteolin 7-glucoside CFN91094 54300-65-1 C21H20O12 = 464.38 10mg QQ客服:2056216494
    假荆芥属苷; Nepetin-7-glucoside CFN90438 569-90-4 C22H22O12 = 478.40 20mg QQ客服:2159513211
    万寿菊苷; Patulitrin CFN95153 19833-25-1 C22H22O13 = 494.4 10mg QQ客服:1413575084
    槲皮万寿菊素 3-甲氧基 7-葡萄糖苷; Quercetagetin 3-methyl ether 7-glucoside CFN95632 76060-29-2 C22H22O13 = 494.4 5mg QQ客服:215959384
    柯伊利素-7-O-葡萄糖苷; Chrysoeriol-7-O-glucoside CFN93021 19993-32-9 C22H22O11 = 462.4 5mg QQ客服:215959384
    香叶木素7-O-beta-D-葡萄糖苷; Diosmetin-7-O-beta-D-glucopyranoside CFN98502 20126-59-4 C22H22O11 = 462.41 20mg QQ客服:3257982914
    地奥司明; Diosmin CFN98145 520-27-4 C28H32O15 = 608.54 20mg QQ客服:1457312923

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