| Molecules. 2016 Mar 25;21(4):404. |
| The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed: 27023504 ] |
METHODS AND RESULTS:
The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
CONCLUSIONS:
Out of the five compounds in the CF, 1β,10β-epoxydesacetoxymatricarin (CP1) and Leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results. |
| Planta Med. 1998 Aug;64(6):577-8. |
| Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.[Pubmed: 9741305] |
METHODS AND RESULTS:
The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property.
CONCLUSIONS:
It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and Leucodin, were also examined and their IC50 values were determined as 100 microM and 80 microM, respectively. |
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