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  • 11beta,13-二氢山莴苣素

    11beta,13-Dihydrolactucin

    11beta,13-二氢山莴苣素
    产品编号 CFN95433
    CAS编号 83117-63-9
    分子式 = 分子量 C15H18O5 = 278.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Picris hieracioides L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    11beta,13-二氢山莴苣素 CFN95433 83117-63-9 1mg QQ客服:1413575084
    11beta,13-二氢山莴苣素 CFN95433 83117-63-9 5mg QQ客服:1413575084
    11beta,13-二氢山莴苣素 CFN95433 83117-63-9 10mg QQ客服:1413575084
    11beta,13-二氢山莴苣素 CFN95433 83117-63-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Sci.2021, 313:111069.
  • J Ethnopharmacol.2017, 196:75-83
  • J Sci Food Agric.2022, 102(4):1628-1639
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Aquaculture2017, 481:94-102
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • Food Research2021, 5(1):65-71
  • Biomolecules.2021, 11(10):1537.
  • Horticulturae2021, 7(1),5.
  • J Nat Prod.2018, 81(4):966-975
  • Molecules.2019, 24(24):E4536
  • Plant J.2021, 107(6):1711-1723.
  • Br J Pharmacol.2018, 175(6):902-923
  • Front Pharmacol.2022, 13:919230.
  • Molecules2021, 26(1),230
  • J Agric Food Chem.2016, 64(35):6783-90
  • Foods.2021, 10(6):1378.
  • Applied Biological Chemistry2020, 63:33(2020)
  • Nat Prod Communications2018, 10.1177
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • J Appl Pharm Sci.2022, 12(04):044-053
  • Nat Prod Sci.2014, 20(3):182-190
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • ...
  • 生物活性
    Description: 11beta,13-Dihydrolactucin has analgesic effect and anti-inflammatory potential .
    In vitro:
    Nutrients . 2020 Nov 19;12(11):3547.
    Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory[Pubmed: 33228214]
    Cichorium intybus L. has recently gained major attention due to large quantities of health-promoting compounds in its roots, such as inulin and sesquiterpene lactones (SLs). Chicory is the main dietary source of SLs, which have underexplored bioactive potential. In this study, we assessed the capacity of SLs to permeate the intestinal barrier to become physiologically available, using in silico predictions and in vitro studies with the well-established cell model of the human intestinal mucosa (differentiated Caco-2 cells). The potential of SLs to modulate inflammatory responses through modulation of the nuclear factor of activated T-cells (NFAT) pathway was also evaluated, using a yeast reporter system. Lactucopicrin was revealed as the most permeable chicory SL in the intestinal barrier model, but it had low anti-inflammatory potential. The SL with the highest anti-inflammatory potential was 11β,13-dihydrolactucin, which inhibited up to 54% of Calcineurin-responsive zinc finger (Crz1) activation, concomitantly with the impairment of the nuclear accumulation of Crz1, the yeast orthologue of human NFAT.
    In vivo:
    J Ethnopharmacol . 2006 Sep 19;107(2):254-258.
    Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice[Pubmed: 16621374]
    Lactucin (1) and its derivatives lactucopicrin (2) and 11beta,13-dihydrolactucin (3), which are characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were evaluated for analgesic and sedative properties in mice. The compounds showed analgesic effects at doses of 15 and 30 mg/kg in the hot plate test similar to that of ibuprofen, used as a standard drug, at a dose of 30 mg/kg. The analgesic activities of the compounds at a dose of 30 mg/kg in the tail-flick test were comparable to that of ibuprofen given at a dose of 60 mg/kg. Lactucopicrin appeared to be the most potent analgetic of the three tested compounds. Lactucin and lactucopicrin, but not 11beta,13-dihydrolactucin, also showed sedative properties in the spontaneous locomotor activity test.
    Nutrients . 2020 Nov 28;12(12):3675.
    Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans[Pubmed: 33260567]
    Free and glycosylated sesquiterpene lactones (SLs), which are abundant in leafy vegetables including Brussels/witloof chicory, possess health-promoting effects in vivo. However, the pharmacokinetics of dietary source of SLs remain largely unknown. In this open-label and single-dose trial, sixteen healthy volunteers consumed 150 g of Brussels/witloof chicory juice containing 48.77 μmol SLs in 5 min. Blood, urine, and fecal samples were collected before and after chicory consumption in 24 h. No SLs were detected in the serum, urine, and fecal samples before chicory consumption in all of the participants. Chicory consumption increased lactucin, 11β,13-dihydrolactucin, and their glucuronide/sulfate conjugates, rather than lactucopicrin and 11β,13-dihydrolactucopicrin, as well as glycosylated SLs in biological samples. The peak concentration of total SLs in serum reached 284.46 nmol/L at 1 h, while, in urine, this peak was 220.3 nmol between 2 and 6 h. The recovery of total SLs in blood, urine, and feces was 7.03%, 1.13%, and 43.76% of the ingested dose, respectively. Human fecal suspensions with intestinal microbiota degraded glycosylated SLs in chicory, and converted lactucopicrin and 11β,13-dihydrolactucopicrin to lactucin and 11β,13-dihydrolactucin, respectively. Collectively, Brussels/witloof chicory SLs are poorly bioavailable and they undergo partial gut microbial and phase II metabolism in humans.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5932 mL 17.9662 mL 35.9324 mL 71.8649 mL 89.8311 mL
    5 mM 0.7186 mL 3.5932 mL 7.1865 mL 14.373 mL 17.9662 mL
    10 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
    50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.4373 mL 1.7966 mL
    100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    11beta,13-二氢山莴苣素; 11beta,13-Dihydrolactucin CFN95433 83117-63-9 C15H18O5 = 278.3 5mg QQ客服:1413575084
    Artemyriantholide D; Artemyriantholide D CFN89190 421558-76-1 C30H36O6 = 492.61 5mg QQ客服:1413575084
    去氢木香内酯; Dehydrocostus lactone CFN98720 477-43-0 C15H18O2 = 230.3 20mg QQ客服:215959384
    磺酸基木香烯内酯A; Sulfocostunolide A CFN99030 1016983-51-9 C15H20O5S = 312.4 5mg QQ客服:1413575084
    磺酸基木香烯内酯B; Sulfocostunolide B CFN99075 1059671-65-6 C15H20O5S = 312.4 5mg QQ客服:3257982914
    1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide; 1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide CFN89195 221148-94-3 C15H20O5 = 280.32 5mg QQ客服:2932563308
    林泽兰内酯B; Eupalinilide B CFN90378 757202-08-7 C20H24O6 = 360.41 10mg QQ客服:3257982914
    林泽兰内酯C; Eupalinilide C CFN90379 757202-11-2 C20H24O7 = 376.4 5mg QQ客服:2932563308
    林泽兰内酯D; Eupalinilide D CFN90380 757202-14-5 C15H19ClO5 = 314.76 10mg QQ客服:1148253675
    8-Epicrepiside E; 8-Epicrepiside E CFN96796 93395-30-3 C21H28O9 = 424.44 5mg QQ客服:2159513211

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