1beta,10beta-Epoxydesacetoxymatricarin

	产品编号	CFN89005
	CAS编号	124020-39-9
	分子式 = 分子量	C₁₅H₁₈O₄ = 262.30
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The herbs of Achillea wilhelmsii.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
1beta,10beta-Epoxydesacetoxymatricarin	CFN89005	124020-39-9	1mg	QQ客服：3257982914
1beta,10beta-Epoxydesacetoxymatricarin	CFN89005	124020-39-9	5mg	QQ客服：3257982914
1beta,10beta-Epoxydesacetoxymatricarin	CFN89005	124020-39-9	10mg	QQ客服：3257982914
1beta,10beta-Epoxydesacetoxymatricarin	CFN89005	124020-39-9	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Heinrich-Heine-University Düsseldorf (Germany)

Chinese University of Hong Kong (China)

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Description:

1beta,10beta-Epoxydesacetoxymatricarin shows high anti-hypercholesterolemic potential.

Targets:

HMG-CoA Reductase | TNF-α | MMP(e.g.TIMP)

In vivo:

Molecules. 2016 Mar 25;21(4):404.

The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed: 27023504 ]

This study was done to identify the content compounds of Achillea wilhelmsii (A. wilhelmsii) and to evaluate its hypoglycemic and anti-hypercholesterolemic activity and effect on inflammatory mediators.
METHODS AND RESULTS:
The extracts and fractions of A. wilhelmsii were thoroughly analyzed using high performance liquid chromatography (HPLC), and the total content of phenols and flavonoids was determined. The hypoglycemic activity was evaluated in vivo using alloxan-induced diabetic mice. The effect upon inflammatory mediators was evaluated in vitro using the human monocytic leukemia cell line (THP-1). The anti-hypercholesterolemic activity was evaluated in vitro using the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase assay kit. The water extract (WE)-treated group showed the highest reduction in the fasting blood glucose levels (FBGL). The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
METHODS AND RESULTS:
Out of the five compounds in the CF,1beta,10beta-Epoxydesacetoxymatricarin (CP1) and leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Artemyriantholide D; Artemyriantholide D	CFN89190	421558-76-1	C₃₀H₃₆O₆ = 492.61	5mg	QQ客服：215959384
去氢木香内酯; Dehydrocostus lactone	CFN98720	477-43-0	C₁₅H₁₈O₂ = 230.3	20mg	QQ客服：1457312923
磺酸基木香烯内酯A; Sulfocostunolide A	CFN99030	1016983-51-9	C₁₅H₂₀O₅S = 312.4	5mg	QQ客服：215959384
磺酸基木香烯内酯B; Sulfocostunolide B	CFN99075	1059671-65-6	C₁₅H₂₀O₅S = 312.4	5mg	QQ客服：2056216494
1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide; 1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide	CFN89195	221148-94-3	C₁₅H₂₀O₅ = 280.32	5mg	QQ客服：2159513211
林泽兰内酯B; Eupalinilide B	CFN90378	757202-08-7	C₂₀H₂₄O₆ = 360.41	10mg	QQ客服：215959384
林泽兰内酯C; Eupalinilide C	CFN90379	757202-11-2	C₂₀H₂₄O₇ = 376.4	5mg	QQ客服：1457312923
林泽兰内酯D; Eupalinilide D	CFN90380	757202-14-5	C₁₅H₁₉ClO₅ = 314.76	10mg	QQ客服：1413575084
8-Epicrepiside E; 8-Epicrepiside E	CFN96796	93395-30-3	C₂₁H₂₈O₉ = 424.44	5mg	QQ客服：2159513211
菜蓟苦素; Cynaropicrin	CFN93077	35730-78-0	C₁₉H₂₂O₆ = 346.37	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8124 mL	19.0621 mL	38.1243 mL	76.2486 mL	95.3107 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL	15.2497 mL	19.0621 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL	7.6249 mL	9.5311 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.525 mL	1.9062 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.7625 mL	0.9531 mL