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  • 苦参黄素,苦参酮

    Kurarinone

    苦参黄素,苦参酮
    产品编号 CFN92003
    CAS编号 34981-26-5
    分子式 = 分子量 C26H30O6 = 438.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Sophora flavescens Ait.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苦参黄素,苦参酮 CFN92003 34981-26-5 10mg QQ客服:215959384
    苦参黄素,苦参酮 CFN92003 34981-26-5 20mg QQ客服:215959384
    苦参黄素,苦参酮 CFN92003 34981-26-5 50mg QQ客服:215959384
    苦参黄素,苦参酮 CFN92003 34981-26-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Calcutta University (India)
  • University of Wuerzburg (Germany)
  • University of Bordeaux (France)
  • University of Helsinki (Finland)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • FORTH-IMBB (Greece)
  • Mendel University in Brno (Czech Republic)
  • Ateneo de Manila University (Philippines)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Mysore (India)
  • The Ohio State University (USA)
  • Technical University of Denmark (Denmark)
  • Tokyo Woman's Christian University (Japan)
  • Aarhus University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules 2022, 27(3),960.
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Phytomedicine.2019, 67:153159
  • BMC Plant Biol.2020, 20(1):214.
  • Life Sci.2023, 317:121458.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • Inflammation.2015, 38(4):1502-16
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Phytomedicine.2016, 23(4):331-9
  • Research Square2022, rs.3.rs-1948239
  • AMB Express2020. 10(1):126.
  • Applied Biological Chemistry 2021, 64(75)
  • J Sep Sci.2018, 41(9):1938-1946
  • Enzyme Microb Technol.2022, 161:110111.
  • J Cell Mol Med.2023, jcmm.17968.
  • Molecules.2015, 20(10):19172-88
  • Antioxidants (Basel).2021, 10(11):1831.
  • Archives of Biological sciences2022, 00:21-21
  • Plants (Basel).2023, 12(22):3877.
  • JABS2020, 14:2(2020)
  • J Ethnopharmacol.2017, 198:91-97
  • Antioxidants (Basel).2020, 9(2): E119
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • ...
  • 生物活性
    Description: Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response. Kurarinone sensitizes TNF-related apoptosis inducing ligand (TRAIL)-induced tumor cell apoptosis via suppression of NF-κB-dependent cFLIP expression; it may be by way of down-regulating Smad3 expression to interfere its induction on intercellular signal transduction and consequently ameliorate renal interstitial fibrosis.
    Targets: JAK | STAT | NF-kB | Bcl-2/Bax | IkB | IKK | TNF-α | CD4(+)
    In vitro:
    J. Nat.Prod., 2004, 67(11):1829-32.
    Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens.[Pubmed: 15568770 ]
    Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays.
    METHODS AND RESULTS:
    Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.
    In vivo:
    Biochem. Pharmacol., 2013, 85(8):1134-44.
    Kurarinone regulates immune responses through regulation of the JAK/STAT and TCR-mediated signaling pathways.[Pubmed: 23333426 ]
    Sophora flavescens is a medicinal herb that contains flavonoids and quinolizidine alkaloids and has a wide range of biological activities due to its anti-inflammatory, anti-bacterial and anti-cancer properties. We isolated a series of flavonoids from the roots of Sophora flavescens and examined their ability to inhibit immune responses.
    METHODS AND RESULTS:
    Among the flavonoids, Kurarinone exhibited the strongest inhibitory effect on immune responses. Kurarinone suppressed the differentiation of CD4(+) T cells by inhibiting the expression and production of T-cell lineage-specific master regulators and cytokines. Our results also demonstrated that Kurarinone directly suppressed the cytokine-induced Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling and T-cell receptor (TCR) pathways. In two established animal models of chronic inflammatory skin disease, one in which psoriasis-like skin disease was induced by an interleukin 23 (IL-23) injection into mouse ears and another in which 2,4,6-trinitrochlorobenzene (TNCB) application on the abdomens of mice was used to induce contact dermatitis, Kurarinone repressed disease development by inhibiting the expression of pro-inflammatory mediators, including cytokines, chemokines and enzyme in murine ear skin.
    CONCLUSIONS:
    This study provides new evidence that Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response.
    Int Immunopharmacol . 2018 Sep;62:227-236.
    The flavonoid kurarinone inhibits clinical progression of EAE through inhibiting Th1 and Th17 cell differentiation and proliferation[Pubmed: 30031314]
    Abstract Introduction: The flavonoid kurarinone suppresses CD4+ T-cell-mediated chronic inflammatory dermatitis. However, kurarinone's effects upon autoimmune central nervous system (CNS) disease remain unknown. We investigated the potential therapeutic effects and molecular mechanism(s) of kurarinone in an experimental autoimmune encephalomyelitis (EAE) murine model of multiple sclerosis (MS). Materials and methods: Myelin oligodendrocyte glycoprotein (MOG35-55) peptide-induced EAE was constructed in wild-type mice. Effects of kurarinone (100 mg/kg/day) upon clinical scores were assessed based on physical traits and signs. Spinal cord sections were extracted to assess inflammation, demyelination, and mRNA expression of key pro-inflammatory cytokines and chemokines. CNS-infiltrating mononuclear cells (MNCs) and splenocytes were harvested; flow cytometry was then applied to determine CD4+ and CD8+ T-cell percentages as well as Th1/Th2/Th17 subset percentages. Purified naïve CD4+ T-cells underwent in vitro T-cell polarization and proliferation to assess kurarinone's effects. Results: Prophylactic and treatment regimens of kurarinone significantly improved clinical scores in the MOG35-55 peptide-induced EAE model (P < 0.05). Kurarinone significantly lowered CNS inflammation and demyelination (61% and 83% decreases, respectively; P < 0.05), significantly decreased MNC infiltration into CNS tissue (42% decrease; P < 0.05), and significantly inhibited levels of several pro-inflammatory cytokines and chemokines (P < 0.05). Kurarinone significantly lowered CD4+ and CD8+ CNS T-cell counts (51% and 80% decreases, respectively; P < 0.05) and significantly reduced CNS Th1 and Th17 cell percentages (24% and 44% decreases, respectively; P < 0.05). Kurarinone significantly inhibited in vitro Th1, Th2, and Th17 cell differentiation and proliferation (P < 0.05). Conclusions: Kurarinone significantly inhibits the clinical progression of EAE through the inhibition of Th1 and Th17 cell differentiation and proliferation. Kurarinone may show promise as an immunomodulatory therapeutic agent in treating MS. Keywords: Encephalomyelitis; Flavonoid; Kurarinone; Multiple sclerosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2805 mL 11.4025 mL 22.805 mL 45.61 mL 57.0125 mL
    5 mM 0.4561 mL 2.2805 mL 4.561 mL 9.122 mL 11.4025 mL
    10 mM 0.2281 mL 1.1403 mL 2.2805 mL 4.561 mL 5.7013 mL
    50 mM 0.0456 mL 0.2281 mL 0.4561 mL 0.9122 mL 1.1403 mL
    100 mM 0.0228 mL 0.114 mL 0.2281 mL 0.4561 mL 0.5701 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    槐黄烷酮G; Sophoraflavanone G CFN92005 97938-30-2 C25H28O6 = 424.5 20mg QQ客服:1413575084
    苦参新醇 F; Kushenol F CFN93051 34981-24-3 C25H28O6 = 424.5 5mg QQ客服:1457312923
    苦参黄素,苦参酮; Kurarinone CFN92003 34981-26-5 C26H30O6 = 438.5 20mg QQ客服:1413575084
    苦参醇; Kurarinol CFN92533 855746-98-4 C26H32O7 = 456.5 5mg QQ客服:215959384
    里查酮A; Leachianone A CFN97560 97938-31-3 C26H30O6 = 438.5 5mg QQ客服:3257982914
    2'-甲氧基苦参黄素; 2'-Methoxykurarinone CFN92004 270249-38-2 C27H32O6 = 452.6 5mg QQ客服:2056216494
    苦参醇B; Kushenol B CFN92348 99217-64-8 C30H36O6 = 492.6 5mg QQ客服:1413575084
    槐黄烷酮 I; Sophoraflavanone I CFN96552 136997-69-8 C39H38O9 = 650.72 5mg QQ客服:2056216494
    槐黄烷酮 H; Sophoraflavanone H CFN96553 136997-68-7 C34H30O9 = 582.60 5mg QQ客服:1457312923
    Alopecurone A; Alopecurone A CFN95512 162558-89-6 C39H38O9 = 650.7 10mg QQ客服:2159513211

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