| In vivo: |
| Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):446-9. | | Effect of kurarinol on peripheral blood CTL surface PD-1 expression of patients with chronic hepatitis B.[Pubmed: 23627026] | To explore the anti-viral mechanism of Kurarinol through studying its influence on cytotoxic T lymphocyte (CTL) surface program death receptor-1 (PD-1) expression of patients with chronic hepatitis B (CHB).
METHODS AND RESULTS:
69 cases of CHB, HBV DNA > or = 10(4) copies/ml, HBeAg positive, human leukocyte antigen (HLA)-A2 positive, alanine aminotransferase (ALT) > 2 x upper limit of normal value(ULN).69 cases were randomly divided into two groups:34 cases in treatment group,600 mg of Kurarinol glucose injection was used for intravenous dripping, once a day, one month later, 200 mg of Kurarinol capsule was used orally,three times a day and 200 mg of silybin meglumine tablet was used orally, three times a day.
CONCLUSIONS:
Kurarinol can increase level of HBV specific CTL by down-regulating peripheral blood HBV specific CTL surface PD-1 expression of CHB patients, which may be one of the possible mechanisms that Kurarinol can remove or inhibit HBV of CHB patients. | | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Apr;26(2):108-10. | | Study on effects of kurarinol combined with glycyrrhizic acid on cellular immunity of patients with chronic hepatitis B.[Pubmed: 23002547] | To explore effects of Kurarinol combined with Diammonium Glycyrrhizinate on specific cellular immunity of patients with chronic hepatitis B (CHB).
METHODS AND RESULTS:
Sixty-three CHB patients were randomly divided into two groups, 32 cases in group of Kurarinol combined with Diammonium Glycyrrhizinate group (combined therapy group) were treated with 600 mg Kurarinol glucose injection intravenously, once a day for one month, then 200 mg Kurarinol capsule was used orally, three times a day for two months. 150 mg Diammonium Glycyrrhizinate for Injection was added to 250 ml 10% glucose injection for intravenous drip, once a day for one month, then 150 mg Diammonium Glycyrrhizinate capsule was used orally, three times a day for two months; 31 case in Kurarinol group (single drug group) only used Kurarinol, methods and dosage were the same as those of treatment group.
CONCLUSIONS:
Kurarinol combined with Diammonium Glycyrrhizinate can further increase HBV specific CTL, CD4+ and Th1 level of CHB patients. |
|
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