Alopecurone A
Alopecurone A
|
|
产品编号 |
CFN95512 |
| CAS编号 |
162558-89-6 |
| 分子式 = 分子量 |
C39H38O9 = 650.7 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The herbs of Sophora alopecuroides |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| Alopecurone A |
CFN95512 |
162558-89-6 |
1mg |
QQ客服：215959384 |
| Alopecurone A |
CFN95512 |
162558-89-6 |
5mg |
QQ客服：215959384 |
| Alopecurone A |
CFN95512 |
162558-89-6 |
10mg |
QQ客服：215959384 |
| Alopecurone A |
CFN95512 |
162558-89-6 |
20mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
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IF=12.804(2019)PMID: 30417089
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Deutsches Krebsforschungszentrum (Germany)
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Alopecurone A exhibits potent inhibitory activity on MRP1.Alopecurone A exhibits cytotoxic activity in DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) cell lines with IC50 values of 2.44 and 5.44 μg/mL. respectively.Alopecurone A has antibacterial activity against methicillin-resistant Staphylococcus aureus. |
| In vitro: |
| Nat Prod Res. 2014;28(23):2195-2198. | | Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors[Pubmed: 24956120] | | Flavonoids have always attracted much attention due to their reversal activity on multidrug resistance (MDR). Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay. Three flavonostilbenes (alopecurone A, B and D) were first found exhibiting potent inhibitory activity on MRP1. All of them dramatically increased 6-carboxyfluorescein diacetate and doxorubicin accumulation in MRP1-transfected U-2 OS cells. The compounds significantly increased the cytotoxicity and decreased the IC₅₀ value of doxorubicin on the MDR cells (12-, 5- and 8-fold, respectively) at a non-toxic concentration (20 μM). Besides, Q-PCR analysis reveals that the MRP1 mRNA level in U-2 OS/MRP1 was also markedly decreased by the three compounds. These findings indicate a new therapeutic role of the herb. The three flavonostilbenes may have the possibility for further development as novel therapeutic reversal agents against MDR. | | Lett Appl Microbiol. 1995 Oct;21(4):219-222. | | Antibacterial activity of flavanostilbenes against methicillin-resistant Staphylococcus aureus[Pubmed: 7576511] | | Three phytochemical compounds (alopecurone A-C), flavanostilbenes which are produced by condensation between a hydroxyflavanone and a hydroxystilbene, were isolated as major components from the root of Sophora alopecuroides. They uniformly inhibited the growth of 21 strains of methicillin-resistant Staphylococcus aureus with minimum inhibitory concentrations of 3.13-6.25 micrograms ml-1. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.5368 mL |
7.684 mL |
15.3681 mL |
30.7361 mL |
38.4202 mL |
| 5 mM |
0.3074 mL |
1.5368 mL |
3.0736 mL |
6.1472 mL |
7.684 mL |
| 10 mM |
0.1537 mL |
0.7684 mL |
1.5368 mL |
3.0736 mL |
3.842 mL |
| 50 mM |
0.0307 mL |
0.1537 mL |
0.3074 mL |
0.6147 mL |
0.7684 mL |
| 100 mM |
0.0154 mL |
0.0768 mL |
0.1537 mL |
0.3074 mL |
0.3842 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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