Alopecurone A

	产品编号	CFN95512
	CAS编号	162558-89-6
	分子式 = 分子量	C₃₉H₃₈O₉ = 650.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Sophora alopecuroides
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Alopecurone A	CFN95512	162558-89-6	1mg	QQ客服：215959384
Alopecurone A	CFN95512	162558-89-6	5mg	QQ客服：215959384
Alopecurone A	CFN95512	162558-89-6	10mg	QQ客服：215959384
Alopecurone A	CFN95512	162558-89-6	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Illinois (USA)

University of Wollongong (Australia)

Universita' Degli Studi Di Cagliari (Italy)

University of Vienna (Austria)

University of South Australia (Australia)

Uniwersytet Jagielloński w Krakowie (Poland)

Universidad de Antioquia (Colombia)

University of Wuerzburg (Germany)

Complutense University of Madrid (Spain)

Wroclaw Medical University (Poland)

University of Otago (New Zealand)

Massachusetts General Hospital (USA)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

Washington State University (USA)

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Description:

Alopecurone A exhibits potent inhibitory activity on MRP1.Alopecurone A exhibits cytotoxic activity in DU145 (prostate cancer cell line) and MCF-7 (breast cancer cell line) cell lines with IC50 values of 2.44 and 5.44 μg/mL. respectively.Alopecurone A has antibacterial activity against methicillin-resistant Staphylococcus aureus.

In vitro:

Nat Prod Res. 2014;28(23):2195-2198.

Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors[Pubmed: 24956120]

Flavonoids have always attracted much attention due to their reversal activity on multidrug resistance (MDR). Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay. Three flavonostilbenes (alopecurone A, B and D) were first found exhibiting potent inhibitory activity on MRP1. All of them dramatically increased 6-carboxyfluorescein diacetate and doxorubicin accumulation in MRP1-transfected U-2 OS cells. The compounds significantly increased the cytotoxicity and decreased the IC₅₀ value of doxorubicin on the MDR cells (12-, 5- and 8-fold, respectively) at a non-toxic concentration (20 μM). Besides, Q-PCR analysis reveals that the MRP1 mRNA level in U-2 OS/MRP1 was also markedly decreased by the three compounds. These findings indicate a new therapeutic role of the herb. The three flavonostilbenes may have the possibility for further development as novel therapeutic reversal agents against MDR.

Lett Appl Microbiol. 1995 Oct;21(4):219-222.

Antibacterial activity of flavanostilbenes against methicillin-resistant Staphylococcus aureus[Pubmed: 7576511]

Three phytochemical compounds (alopecurone A-C), flavanostilbenes which are produced by condensation between a hydroxyflavanone and a hydroxystilbene, were isolated as major components from the root of Sophora alopecuroides. They uniformly inhibited the growth of 21 strains of methicillin-resistant Staphylococcus aureus with minimum inhibitory concentrations of 3.13-6.25 micrograms ml-1.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
槐黄烷酮G; Sophoraflavanone G	CFN92005	97938-30-2	C₂₅H₂₈O₆ = 424.5	20mg	QQ客服：2056216494
苦参新醇 F; Kushenol F	CFN93051	34981-24-3	C₂₅H₂₈O₆ = 424.5	5mg	QQ客服：1457312923
苦参黄素，苦参酮; Kurarinone	CFN92003	34981-26-5	C₂₆H₃₀O₆ = 438.5	20mg	QQ客服：1413575084
苦参醇; Kurarinol	CFN92533	855746-98-4	C₂₆H₃₂O₇ = 456.5	5mg	QQ客服：3257982914
里查酮A; Leachianone A	CFN97560	97938-31-3	C₂₆H₃₀O₆ = 438.5	5mg	QQ客服：2159513211
2'-甲氧基苦参黄素; 2'-Methoxykurarinone	CFN92004	270249-38-2	C₂₇H₃₂O₆ = 452.6	5mg	QQ客服：2056216494
苦参醇B; Kushenol B	CFN92348	99217-64-8	C₃₀H₃₆O₆ = 492.6	5mg	QQ客服：1457312923
槐黄烷酮 I; Sophoraflavanone I	CFN96552	136997-69-8	C₃₉H₃₈O₉ = 650.72	5mg	QQ客服：3257982914
槐黄烷酮 H; Sophoraflavanone H	CFN96553	136997-68-7	C₃₄H₃₀O₉ = 582.60	5mg	QQ客服：1457312923
Alopecurone A; Alopecurone A	CFN95512	162558-89-6	C₃₉H₃₈O₉ = 650.7	10mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5368 mL	7.684 mL	15.3681 mL	30.7361 mL	38.4202 mL
5 mM	0.3074 mL	1.5368 mL	3.0736 mL	6.1472 mL	7.684 mL
10 mM	0.1537 mL	0.7684 mL	1.5368 mL	3.0736 mL	3.842 mL
50 mM	0.0307 mL	0.1537 mL	0.3074 mL	0.6147 mL	0.7684 mL
100 mM	0.0154 mL	0.0768 mL	0.1537 mL	0.3074 mL	0.3842 mL