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  • 异乌药内酯

    Isolinderalactone

    异乌药内酯
    产品编号 CFN99762
    CAS编号 957-66-4
    分子式 = 分子量 C15H16O3 = 244.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Lindera aggregata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异乌药内酯 CFN99762 957-66-4 1mg QQ客服:2056216494
    异乌药内酯 CFN99762 957-66-4 5mg QQ客服:2056216494
    异乌药内酯 CFN99762 957-66-4 10mg QQ客服:2056216494
    异乌药内酯 CFN99762 957-66-4 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Zurich (Switzerland)
  • University of Sao Paulo (Brazil)
  • Heidelberg University (Germany)
  • Monash University (Australia)
  • University of Helsinki (Finland)
  • Universidad Veracuzana (Mexico)
  • University of South Australia (Australia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Tohoku University (Japan)
  • Copenhagen University (Denmark)
  • National Chung Hsing University (Taiwan)
  • Shanghai Institute of Organic Chemistry (China)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Oslo (Norway)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol.2022, 106:108603.
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • Int J Mol Sci.2019, 20(23):E6071
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Antioxidants (Basel).2020, 9(7):581.
  • Univerzita Karlova2022, 173245.
  • Integr Cancer Ther.2018, 17(3):832-843
  • Int J Mol Sci.2021, 22(12):6466.
  • J Ethnopharmacol.2016, 194:219-227
  • Nutrients.2021, 13(10):3414.
  • Eur J Pharmacol.2022, 917:174744.
  • Food Chem.2019, 278:683-691
  • Chem Biol Interact.2019, 315:108910
  • Free Radic Biol Med.2016, 97:307-319
  • Int J Mol Sci.2019, 20(9):E2244
  • Molecules.2022, 27(4):1412.
  • Pharmacol Rep.2020, 72(2):472-480.
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • J Biol Chem.2014, 289(3):1723-31
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • ...
  • 生物活性
    Description: Isolinderalactone shows anti-inflammatory and anticancer capacity, it induces apoptosis in MDA-MB-231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c, may become a novel treatment for triple-negative breast cancer in the future; it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
    Targets: p21 | NOS | Caspase | STAT | SOCS3 | miR-30c
    In vitro:
    J Nat Prod. 2011 Dec 27;74(12):2489-96.
    Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.[Pubmed: 22148193]
    Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds.
    METHODS AND RESULTS:
    The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18.41, 0.30, 19.55, and 10.50 μM, respectively.
    Oncol Rep. 2016 Mar;35(3):1356-64.
    Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer.[Pubmed: 26707189]
    Development of an efficient treatment for triple-negative breast cancer is an urgent issues. Compounds from plant extracts are a potential source of novel cancer treatment. Isolinderalactone, a kind of sesquiterpenoids compound, was purified from the root of Lindera strychnifolia and Neolitsea daibuensis and shows anti-inflammatory and anticancer capacity.
    METHODS AND RESULTS:
    In the present study, Isolinderalactone induced apoptosis in MDA-MB-231 cells which is a kind of triple-negative breast cancer cell line through induction of an intrinsic mitochondria-mediated and caspase-independent cell death. Treatment of Isolinderalactone increased the protein level of the suppressor of cytokine signaling 3 (SCOS3), decreased phosphorylation of the signal transducer and activator of transcription 3 (STAT3), and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein in MDA-MB-231 cells. Our results further showed that the level of SOCS3 expression was induced by Isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p (miR-30c) expression. In addition, intraperitoneal injection of Isolinderalactone induced apoptosis in a xenograft breast tumor while it did not significantly affect the histology of liver, kidney and lung of the treated mice.
    CONCLUSIONS:
    In conclusion, Isolinderalactone induces apoptosis in MDA-MB‑231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c. It may become a novel treatment for triple-negative breast cancer in the future.
    In vivo:
    Cancer Lett . 2020 May 28;478:71-81
    Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models[Pubmed: 32173479]
    Abstract Glioblastoma multiforme (GBM) is a lethal and highly vascular type of brain tumor. We previously reported that isolinderalactone enhances GBM apoptosis in vitro and in vivo, but its role in tumor angiogenesis is unknown. Here, we investigated the anti-angiogenic activity of isolinderalactone and its mechanisms. In a human GBM xenograft mouse model, isolinderalactone significantly reduced tumor growth and vessels. Isolinderalactone decreased the expression of vascular endothelial growth factor (VEGF) mRNA, protein, and VEGF secretion in hypoxic U-87 GBM cells and also in xenograft GMB tissue. In addition, we demonstrated that isolinderalactone significantly inhibited the proliferation, migration, and capillary-like tube formation of human brain microvascular endothelial cells (HBMECs) in the presence of VEGF. We also found that isolinderalactone decreased sprout diameter and length in a 3D microfluidic chip, and strongly reduced VEGF-triggered angiogenesis in vivo Matrigel plug assay. Isolinderalactone downregulated hypoxia-inducible factor-1α (HIF-1α) and HIF-2α proteins, decreased luciferase activity driven by the VEGF promoter in U-87 cells under hypoxic conditions, and suppressed VEGF-driven phosphorylation of VEGFR2 in HBMECs. Taken together, our results suggest that isolinderalactone is a promising candidate for GBM treatment through tumor angiogenesis inhibition. Keywords: 3D microfluidic chip; Angiogenesis; Brain tumor; Hypoxia-inducible factor; Vascular endothelial growth factor.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0935 mL 20.4675 mL 40.935 mL 81.8699 mL 102.3374 mL
    5 mM 0.8187 mL 4.0935 mL 8.187 mL 16.374 mL 20.4675 mL
    10 mM 0.4093 mL 2.0467 mL 4.0935 mL 8.187 mL 10.2337 mL
    50 mM 0.0819 mL 0.4093 mL 0.8187 mL 1.6374 mL 2.0467 mL
    100 mM 0.0409 mL 0.2047 mL 0.4093 mL 0.8187 mL 1.0234 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane; 6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane CFN89320 59780-08-4 C20H24O5 = 344.40 5mg QQ客服:2159513211
    莪术呋喃烯酮; Curzerenone CFN92027 20493-56-5 C15H18O2 = 230.3 10mg QQ客服:215959384
    表莪术呋喃烯酮; Epicurzerenone CFN92613 20085-85-2 C15H18O2 = 230.3 5mg QQ客服:215959384
    异乌药内酯; Isolinderalactone CFN99762 957-66-4 C15H16O3 = 244.29 10mg QQ客服:1413575084
    苍术酮; Atractylone CFN92066 6989-21-5 C15H20O = 216.3 5mg QQ客服:1457312923
    乌药醇; Linderene CFN90639 26146-27-0 C15H18O2 = 230.3 10mg QQ客服:215959384
    乌药醇乙酸酯; Linderene acetate CFN91930 26146-28-1 C17H20O3 = 272.34 5mg QQ客服:3257982914
    Strychnistenolide; Strychnistenolide CFN91933 332372-09-5 C15H18O4 = 262.30 5mg QQ客服:3257982914
    8beta,9alpha-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide; 8beta,9alpha-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide CFN91948 956707-04-3 C15H18O4 = 262.30 5mg QQ客服:3257982914
    姜黄醇酮; Curcolone CFN92651 17015-43-9 C15H18O3 = 246.3 5mg QQ客服:1457312923

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