Info: Read More
  • 中药标准品生产商,产品定制服务
  • 异乌药内酯


    产品编号 CFN99762
    CAS编号 957-66-4
    分子式 = 分子量 C15H16O3 = 244.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Lindera aggregata
    产品名称 产品编号 CAS编号 包装 QQ客服
    异乌药内酯 CFN99762 957-66-4 1mg QQ客服:2932563308
    异乌药内酯 CFN99762 957-66-4 5mg QQ客服:2932563308
    异乌药内酯 CFN99762 957-66-4 10mg QQ客服:2932563308
    异乌药内酯 CFN99762 957-66-4 20mg QQ客服:2932563308
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: 或

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Universidade de Franca (Brazil)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Sanford Burnham Medical Research Institute (USA)
  • Charles University in Prague (Czech Republic)
  • Georgia Institute of Technology (USA)
  • Griffith University (Australia)
  • Ain Shams University (Egypt)
  • Chinese University of Hong Kong (China)
  • Shanghai University of TCM (China)
  • National Research Council of Canada (Canada)
  • Universidade Federal de Santa Catarina (Brazil)
  • Cornell University (USA)
  • Universidade Católica Portuguesa (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2019, 9(1):4342
  • Foods.2020, 9(10):1348.
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Phytomedicine.2022, 100:154058.
  • Korean J of Crop Science2019, 452-458
  • Phytomedicine.2019, 58:152893
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • J Ginseng Res.2020, 44(4):611-618.
  • Separations2021, 8(6),80.
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • J Cell Biochem.2018, 119(2):2231-2239
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Applied Biological Chem. 2020, 26(63).
  • Wageningen University & Research2018, January 2018
  • Biomed Sci Letters.2020, 26:319-326
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Phytochemistry Letters2015, 243-247
  • Plant Cell Physiol.2018, 59(1):128-141
  • Phytomedicine.2022, 99:154025.
  • Molecules.2021, 26(9):2802.
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Earth Environ. Sci. 2021, 905:012080.
  • ...
  • 生物活性
    Description: Isolinderalactone shows anti-inflammatory and anticancer capacity, it induces apoptosis in MDA-MB-231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c, may become a novel treatment for triple-negative breast cancer in the future; it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
    Targets: p21 | NOS | Caspase | STAT | SOCS3 | miR-30c
    In vitro:
    J Nat Prod. 2011 Dec 27;74(12):2489-96.
    Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.[Pubmed: 22148193]
    Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds.
    The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18.41, 0.30, 19.55, and 10.50 μM, respectively.
    Oncol Rep. 2016 Mar;35(3):1356-64.
    Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer.[Pubmed: 26707189]
    Development of an efficient treatment for triple-negative breast cancer is an urgent issues. Compounds from plant extracts are a potential source of novel cancer treatment. Isolinderalactone, a kind of sesquiterpenoids compound, was purified from the root of Lindera strychnifolia and Neolitsea daibuensis and shows anti-inflammatory and anticancer capacity.
    In the present study, Isolinderalactone induced apoptosis in MDA-MB-231 cells which is a kind of triple-negative breast cancer cell line through induction of an intrinsic mitochondria-mediated and caspase-independent cell death. Treatment of Isolinderalactone increased the protein level of the suppressor of cytokine signaling 3 (SCOS3), decreased phosphorylation of the signal transducer and activator of transcription 3 (STAT3), and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein in MDA-MB-231 cells. Our results further showed that the level of SOCS3 expression was induced by Isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p (miR-30c) expression. In addition, intraperitoneal injection of Isolinderalactone induced apoptosis in a xenograft breast tumor while it did not significantly affect the histology of liver, kidney and lung of the treated mice.
    In conclusion, Isolinderalactone induces apoptosis in MDA-MB‑231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c. It may become a novel treatment for triple-negative breast cancer in the future.
    In vivo:
    Cancer Lett . 2020 May 28;478:71-81
    Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models[Pubmed: 32173479]
    Abstract Glioblastoma multiforme (GBM) is a lethal and highly vascular type of brain tumor. We previously reported that isolinderalactone enhances GBM apoptosis in vitro and in vivo, but its role in tumor angiogenesis is unknown. Here, we investigated the anti-angiogenic activity of isolinderalactone and its mechanisms. In a human GBM xenograft mouse model, isolinderalactone significantly reduced tumor growth and vessels. Isolinderalactone decreased the expression of vascular endothelial growth factor (VEGF) mRNA, protein, and VEGF secretion in hypoxic U-87 GBM cells and also in xenograft GMB tissue. In addition, we demonstrated that isolinderalactone significantly inhibited the proliferation, migration, and capillary-like tube formation of human brain microvascular endothelial cells (HBMECs) in the presence of VEGF. We also found that isolinderalactone decreased sprout diameter and length in a 3D microfluidic chip, and strongly reduced VEGF-triggered angiogenesis in vivo Matrigel plug assay. Isolinderalactone downregulated hypoxia-inducible factor-1α (HIF-1α) and HIF-2α proteins, decreased luciferase activity driven by the VEGF promoter in U-87 cells under hypoxic conditions, and suppressed VEGF-driven phosphorylation of VEGFR2 in HBMECs. Taken together, our results suggest that isolinderalactone is a promising candidate for GBM treatment through tumor angiogenesis inhibition. Keywords: 3D microfluidic chip; Angiogenesis; Brain tumor; Hypoxia-inducible factor; Vascular endothelial growth factor.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0935 mL 20.4675 mL 40.935 mL 81.8699 mL 102.3374 mL
    5 mM 0.8187 mL 4.0935 mL 8.187 mL 16.374 mL 20.4675 mL
    10 mM 0.4093 mL 2.0467 mL 4.0935 mL 8.187 mL 10.2337 mL
    50 mM 0.0819 mL 0.4093 mL 0.8187 mL 1.6374 mL 2.0467 mL
    100 mM 0.0409 mL 0.2047 mL 0.4093 mL 0.8187 mL 1.0234 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane; 6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane CFN89320 59780-08-4 C20H24O5 = 344.40 5mg QQ客服:2159513211
    莪术呋喃烯酮; Curzerenone CFN92027 20493-56-5 C15H18O2 = 230.3 10mg QQ客服:1148253675
    表莪术呋喃烯酮; Epicurzerenone CFN92613 20085-85-2 C15H18O2 = 230.3 5mg QQ客服:1413575084
    异乌药内酯; Isolinderalactone CFN99762 957-66-4 C15H16O3 = 244.29 10mg QQ客服:2159513211
    苍术酮; Atractylone CFN92066 6989-21-5 C15H20O = 216.3 5mg QQ客服:3257982914
    乌药醇; Linderene CFN90639 26146-27-0 C15H18O2 = 230.3 10mg QQ客服:1148253675
    乌药醇乙酸酯; Linderene acetate CFN91930 26146-28-1 C17H20O3 = 272.34 5mg QQ客服:3257982914
    Strychnistenolide; Strychnistenolide CFN91933 332372-09-5 C15H18O4 = 262.30 5mg QQ客服:215959384
    8beta,9alpha-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide; 8beta,9alpha-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide CFN91948 956707-04-3 C15H18O4 = 262.30 5mg QQ客服:215959384
    姜黄醇酮; Curcolone CFN92651 17015-43-9 C15H18O3 = 246.3 5mg QQ客服:2932563308





    在线QQ: 1413575084


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产