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  • 人参皂苷F4

    Ginsenoside F4

    人参皂苷F4
    产品编号 CFN90757
    CAS编号 181225-33-2
    分子式 = 分子量 C42H70O12 = 767.0
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷F4 CFN90757 181225-33-2 1mg QQ客服:1413575084
    人参皂苷F4 CFN90757 181225-33-2 5mg QQ客服:1413575084
    人参皂苷F4 CFN90757 181225-33-2 10mg QQ客服:1413575084
    人参皂苷F4 CFN90757 181225-33-2 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Lund University (Sweden)
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  • University of Medicine and Pharmacy (Romania)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Nanjing University of Chinese Medicine (China)
  • Universite de Lille1 (France)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Phytother Res.2018, 32(5):923-932
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • Molecules.2021, 26(23):7390.
  • Plant Foods Hum Nutr.2020, 10.1007
  • Front Microbiol.2020, 11:583594.
  • Molecules.2020, 25(21):5091.
  • Foods.2021, 10(6):1378.
  • Chem Biol Interact.2018, 283:59-74
  • Front Pharmacol.2021, 12:652860.
  • J Nat Prod.2015, 78(6):1339-4
  • Sci Rep.2021, 11(1):21038.
  • J Appl Biol Chem2022, 65:343−348.
  • Acta Physiologiae Plantarum2016, 38:7
  • Front Pharmacol.2021, 12:765521.
  • Aging (Albany NY).2021, 13(19):22867-22882.
  • Phytomedicine.2019, 57:95-104
  • J Ethnopharmacol.2024, 318:116863.
  • Foods.2022, 11(6):882.
  • Curr Issues Mol Biol.2022, 44(10):5106-5116.
  • Universite de Bordeaux2017, 2017BORD0867
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • ...
  • 生物活性
    Description: Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression. Ginsenoside F4 also has strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways.
    Targets: Bcl-2/Bax | MMP(e.g.TIMP) | IL Receptor | p38MAPK
    In vitro:
    Nat Prod Res. 2013;27(24):2351-4.
    The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells.[Pubmed: 23962295]

    METHODS AND RESULTS:
    In this study, the inhibitory and apoptosis-inducing effect of ginsenoside F4 (GF4) from steamed notoginseng was investigated by using human lymphocytoma Jurkat (JK) cell. Cell Counting Kit-8 method was then used to assess the anti-proliferative effect of GF4, and Western blotting was run to detect the expression level of two apoptosis-related proteins including Bax and the Bcl-2. The results suggested that GF4 can effectively inhibit the proliferation of the cells, and Bax expression increased gradually, but Bcl-2 expression reduced with the increase of GF4 concentration.
    CONCLUSIONS:
    In conclusion, GF4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. The mechanism of action could be related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression by GF4.
    Eur J Pharmacol. 2014 Feb 5;724:145-51.
    Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation.[Pubmed: 24384406]
    Among the mammalian matrix metalloproteinases (MMPs), MMP-1, -3 and -13 are collagenases. Particularly, MMP-13 is important for the degradation of major collagens in cartilage under certain pathological conditions such as osteoarthritis.
    METHODS AND RESULTS:
    To establish a potential therapeutic strategy for cartilage degradation disorders, the effects of 11 ginseng saponins (ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rg5, Rk1 and F4) on MMP-13 induction were examined in a human chondrocyte cell line, SW1353. Among these, several saponins including ginsenoside Rc, Rd, Rf, Rg3 and F4 were found to inhibit MMP-13 expression in IL-1β-treated SW1353 cells at non-cytotoxic concentrations (1-50 μM). The most prominent inhibitors were ginsenosides F4 and Rg3. Ginsenoside F4 inhibited MMP-13 expression 33.5% (P<0.05), 57.9% (P<0.01) and 90.0% (P<0.01) at 10, 30 and 50 μM, respectively. Significantly, Ginsenoside F4 was found to strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways (86.6 and 100.0% inhibition at 30 and 50 μM, P<0.01). The MMP-13 inhibitory effect was also supported by the finding that ginsenosides F4 and Rg3 reduced glycosaminoglycan release from IL-1α-treated rabbit joint cartilage culture to some degree. Taken together, these results indicate that several ginsenosides inhibit MMP-13 expression in IL-1β-treated chondrocytes. Ginsenoside F4 and Rg3 blocked cartilage breakdown in rabbit cartilage tissue culture.
    CONCLUSIONS:
    Thus, it is suggested that certain ginsenosides have therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues such as those found in patients with arthritic disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3038 mL 6.5189 mL 13.0378 mL 26.0756 mL 32.5945 mL
    5 mM 0.2608 mL 1.3038 mL 2.6076 mL 5.2151 mL 6.5189 mL
    10 mM 0.1304 mL 0.6519 mL 1.3038 mL 2.6076 mL 3.2595 mL
    50 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5215 mL 0.6519 mL
    100 mM 0.013 mL 0.0652 mL 0.1304 mL 0.2608 mL 0.3259 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷Rb3; Ginsenoside Rb3 CFN99966 68406-26-8 C53H90O22 = 1079.27 20mg QQ客服:1457312923
    三七皂苷Fc; Notoginsenoside Fc CFN93283 88122-52-5 C58H98O26 = 1211.4 20mg QQ客服:1413575084
    人参皂苷Rb1; Ginsenoside Rb1 CFN99964 41753-43-9 C54H92O23 = 1109.29 20mg QQ客服:2159513211
    三七皂苷Fa; Notoginsenoside Fa CFN93284 88100-04-3 C59H100O27 = 1241.4 20mg QQ客服:2056216494
    三七皂苷R4; Notoginsenoside R4 CFN91142 87741-77-3 C59H100O27 = 1241.4 5mg QQ客服:2056216494
    人参皂苷Ra2; Ginsenoside Ra2 CFN93293 83459-42-1 C58H98O26 = 1211.39 5mg QQ客服:1413575084
    三七皂苷Fe; Notoginsenoside Fe CFN93282 88105-29-7 C47H80O17 = 917.12 20mg QQ客服:2056216494
    人参皂苷Rc; Ginsenoside Rc CFN99973 11021-14-0 C53H90O22 = 1079.27 20mg QQ客服:215959384
    人参皂苷F1; Ginsenoside F1 CFN99754 53963-43-2 C36H62O9 = 638.88 20mg QQ客服:2159513211
    3-乙酰人参皂苷F1; 3-Acetyl-ginsenoside F1 CFN95238 1881225-08-6 C38H64O10 = 680.9 5mg QQ客服:1413575084

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