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  • 达玛-20(22),24-二烯-3β,6α,12β-三醇

    Quasipanaxatriol

    达玛-20(22),24-二烯-3β,6α,12β-三醇
    产品编号 CFN95248
    CAS编号 171903-78-9
    分子式 = 分子量 C30H50O3 = 458.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 1mg QQ客服:1413575084
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 5mg QQ客服:1413575084
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 10mg QQ客服:1413575084
    达玛-20(22),24-二烯-3β,6α,12β-三醇 CFN95248 171903-78-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Eastern Finland (Finland)
  • Universidad de La Salle (Mexico)
  • Medical University of Gdansk (Poland)
  • University of Maryland School of Medicine (USA)
  • Semmelweis Unicersity (Hungary)
  • Celltrion Chemical Research Institute (Korea)
  • Universidade do Porto (Portugal)
  • Michigan State University (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • Kyushu University (Japan)
  • Almansora University (Egypt)
  • Universidad Miguel Hernández (Spain)
  • University of Hertfordshire (United Kingdom)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharm Biomed Anal.2021, 196:113931.
  • Molecules.2021, 26(6):1738.
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Tumour Biol.2015, 36(9):7027-34
  • Biomedicine & Pharmacotherapy2022, 153:113404.
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • South African Journal of Botany2021, 142:114-123.
  • Food Res Int.2021, 148:110607.
  • Evid-Based Compl Alt2020, 7202519:13
  • Process Biochemistry2019, 87:213-220
  • Nat Commun.2019, 10(1):2745
  • Applied Physics B2021, 127(92).
  • Food Chem.2019, 275:746-753
  • Biochem Systematics and Ecology2017, 11-18
  • Plants (Basel).2021, 10(4):702.
  • Molecules 2022, 27(3),1047.
  • J Food Biochem.2020, 44(6):e13198.
  • Food Chem.2020, 332:127412
  • J Pharm Biomed Anal.2017, 140:274-280
  • Huazhong Agricultural University2022, pp34.
  • Int J Mol Sci.2019, 20(11):E2734
  • Biorxiv2019, 10.1101
  • ...
  • 生物活性
    Description: Quasipanaxatriol can greatly enhance the cytotoxicity of the anti-cancer drugs in P388/ADM cells.
    In vitro:
    Planta Med 1995; 61(5): 409-413.
    Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistant P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids.[Reference: WebLink]

    METHODS AND RESULTS:
    Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-protopanaxatriol, ginsenoside Rh2, and compound K greatly enhanced the cytotoxicity of the anti-cancer drugs in P388/ADM cells. The extent of enhancement was different among the triterpene compounds; the 4- to 46-fold increase in DAU cytotoxicity was observed in P388/ADM cells in the presence of non-toxic or marginally toxic concentrations of individual compounds, while those for VBL were in the ratios of 2- to 37-fold. The maximum increase in cytotoxicity was observed with 50 µM quasipanaxatriol; the resistance indices defined to be the ratios of the IC50 values for P388/ADM and P388 parental cells decreased from 79 to 1.7 and from 180 to 4.9 in the cases of DAU and VBL, respectively.
    CONCLUSIONS:
    The reversal of DAU resistance in P388/ADM by quasipanaxatriol could be explained by the effective accumulation of the drugs mediated by the DAU-efflux blockage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1801 mL 10.9004 mL 21.8007 mL 43.6015 mL 54.5019 mL
    5 mM 0.436 mL 2.1801 mL 4.3601 mL 8.7203 mL 10.9004 mL
    10 mM 0.218 mL 1.09 mL 2.1801 mL 4.3601 mL 5.4502 mL
    50 mM 0.0436 mL 0.218 mL 0.436 mL 0.872 mL 1.09 mL
    100 mM 0.0218 mL 0.109 mL 0.218 mL 0.436 mL 0.545 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷F4; Ginsenoside F4 CFN90757 181225-33-2 C42H70O12 = 767.0 5mg QQ客服:1457312923
    达玛-20(22),24-二烯-3β,6α,12β-三醇; Quasipanaxatriol CFN95248 171903-78-9 C30H50O3 = 458.7 5mg QQ客服:1413575084
    人参皂苷MC; Ginsenoside MC CFN95232 175484-06-7 C41H70O12 = 755.0 10mg QQ客服:2159513211
    Gynosaponin I; Gynosaponin I CFN96182 1207861-69-5 C42H72O12 = 769.0 5mg QQ客服:215959384
    人参皂苷TN2; Gynosaponin TN2 CFN95331 77658-95-8 C42H72O13 = 785.0 5mg QQ客服:1413575084
    人参皂苷F2; Ginsenoside F2 CFN99755 62025-49-4 C42H72O13 = 785.01 20mg QQ客服:1457312923
    人参皂苷Rd2; Ginsenoside Rd2 (Quinquenoside L10) CFN95231 83480-64-2 C47H80O17 = 917.2 10mg QQ客服:215959384
    七叶胆苷XVI; Gypenoside XVII CFN90193 80321-69-3 C48H82O18 = 947.16 20mg QQ客服:2056216494
    三七皂苷L13; Notoginsenoside L13 CFN95332 2485859-56-9 C47H78O17 = 915.1 5mg QQ客服:1457312923
    人参皂苷Rb2; Ginsenoside Rb2 CFN99965 11021-13-9 C53H90O22 = 1079.27 20mg QQ客服:1413575084

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