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  • 吉马酮


    产品编号 CFN98133
    CAS编号 6902-91-6
    分子式 = 分子量 C15H22O = 218.34
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma wenyujin.
    产品名称 产品编号 CAS编号 包装 QQ客服
    吉马酮 CFN98133 6902-91-6 10mg QQ客服:3257982914
    吉马酮 CFN98133 6902-91-6 20mg QQ客服:3257982914
    吉马酮 CFN98133 6902-91-6 50mg QQ客服:3257982914
    吉马酮 CFN98133 6902-91-6 100mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

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    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • University of Toulouse (France)
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  • Subang Jaya Medical Centre (Malaysia)
  • Colorado State University (USA)
  • Universidade Federal de Santa Catarina (Brazil)
  • China Medical University (Taiwan)
  • Hamdard University (India)
  • University of Maryland School of Medicine (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • University of Wollongong (Australia)
  • University of Perugia (Italy)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Limpopo (South Africa)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
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  • Front. Pharmacol.2022, 901563.
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  • Preprints2022, 202211.0388.v1.
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  • ...
  • 生物活性
    Description: Germacrone has anti-tumor activity, it can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung. Germacrone also moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM, and produces two oxidized metabolites and four glutathione conjugates.
    Targets: Bcl-2/Bax | Influenza virus | p53 | TNF-α | P-gp | TGF-β/Smad | IL Receptor | CDK | p21 | DNA/RNA Synthesis | STAT | JAK | ROS | P450 (e.g. CYP17)
    In vitro:
    Exp Ther Med. 2014 Nov;8(5):1611-1615.
    Germacrone reverses Adriamycin resistance through cell apoptosis in multidrug-resistant breast cancer cells.[Pubmed: 25289068]
    Multidrug resistance (MDR) is a major obstacle to the chemotherapeutic treatment of breast cancer. Germacrone, the main component of Rhizoma Curcuma, has been shown to possess antitumor, anti-inflammatory and immunomodulatory properties.
    The aim of the present study was to investigate the effect of germacrone on MCF-7/Adriamycin (ADR) multidrug-resistant human breast cancer cells. The treatment of MCF-7/ADR cells with a combination of germacrone and ADR resulted in an increase in cytotoxicity compared with that of ADR alone, as determined using an MTT assay. Flow cytometric analysis revealed that germacrone promoted cell apoptosis in a dose-dependent manner, whilst treatment with germacrone plus ADR enhanced the apoptotic effect synergistically. Furthermore, the results from the western blot analysis demonstrated that augmenting ADR treatment with germacrone resulted in a reduction of anti-apoptotic protein expression levels (bcl-2) and enhancement of pro-apoptotic protein expression levels (p53 and bax) in MCF-7/ADR cells compared with the levels achieved by treatment with ADR alone. In addition, germacrone significantly reduced the expression of P-glycoprotein via the inhibition of the multidrug resistance 1 (MDR1) gene promoter.
    These findings demonstrate that germacrone has a critical role against MDR and may be a novel MDR reversal agent for breast cancer chemotherapy.
    Cell Mol Biol (Noisy-le-grand). 2014 Nov 16;60(4):8-12.
    The effects of germacrone on lipopolysaccharide-induced acute lung injury in neonatal rats.[Pubmed: 25399081]
    Germacrone is one of the main bioactive components in the traditional Chinese medicine Rhizoma curcuma and has been shown to possess an anti-inflammatory activity.
    Our present study aimed to investigate the protective effects of germacrone on lipopolysaccharide (LPS)-induced acute lung injury in neonatal rats. Results showed that germacrone treatment significantly decreased the expression of pro-inflammatory cytokines IL-6 and TNF-α. Meanwhile, the expression of anti-inflammatory mediators TGF-β1 and IL-10 was obviously increased following germacrone administration. The LPS-induced pathological changes in neonatal rats were also attenuated by germacrone treatment. In vitro, MTT and EdU incorporation assay indicated that germacrone administration significantly increased the A549 cell viabilities in a dose-dependent manner. Besides, flow cytometry and TUNEL analysis showed that the cell apoptosis rate was significantly reduced in a concentration-dependent manner after germacrone injection. At the molecular level, we found that germacrone treatment promoted the expression of claudin-4 both in vivo and in vitro as shown by real time PCR and western blot.
    Collectively, our study demonstrated that germacrone protected neonatal rats against LPS-induced ALI partially by modulation of claudin-4.
    Antiviral Res. 2013 Dec;100(3):578-88.
    Germacrone inhibits early stages of influenza virus infection.[Pubmed: 24095670]
    Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains.
    In this study, germacrone, which is a major component of the essential oils extracted from Rhizoma Curcuma, was found to inhibit influenza virus replication. Germacrone showed antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner. The viral protein expression, RNA synthesis and the production of infectious progeny viruses were decreased both in MDCK and A549 cells treated with germacrone. In a time-of-addition study, germacrone was found to exhibit an inhibitory effect on both the attachment/entry step and the early stages of the viral replication cycle. Germacrone also exhibited an effective protection of mice from lethal infection and reduced the virus titres in the lung. Furthermore, the combination of germacrone and oseltamivir exhibited an additive effect on the inhibition of influenza virus infection, both in vitro and in vivo.
    Our results suggest that germacrone may have the potential to be developed as a therapeutic agent alone or in combination with other agents for the treatment of influenza virus infection.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.58 mL 22.9001 mL 45.8001 mL 91.6003 mL 114.5003 mL
    5 mM 0.916 mL 4.58 mL 9.16 mL 18.3201 mL 22.9001 mL
    10 mM 0.458 mL 2.29 mL 4.58 mL 9.16 mL 11.45 mL
    50 mM 0.0916 mL 0.458 mL 0.916 mL 1.832 mL 2.29 mL
    100 mM 0.0458 mL 0.229 mL 0.458 mL 0.916 mL 1.145 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4(15),5,10(14)-大根香叶三烯-1-醇; 4(15),5,10(14)-Germacratrien-1-ol CFN97301 81968-62-9 C15H24O = 220.4 5mg QQ客服:3257982914
    前异菖蒲烯二醇; Preisocalamendiol CFN98286 25645-19-6 C15H24O = 220.4 5mg QQ客服:1457312923
    莪术二酮; Curdione CFN99146 13657-68-6 C15H24O2 = 236.34 20mg QQ客服:2159513211
    吉马酮; Germacrone CFN98133 6902-91-6 C15H22O = 218.34 20mg QQ客服:1413575084
    吉马酮-4,5-环氧化物; Germacrone 4,5-epoxide CFN96431 92691-35-5 C15H22O2 = 234.33 5mg QQ客服:3257982914
    1,10:4,5-二环氧-7(11)-吉玛烯-8-酮; 1,10:4,5-Diepoxy-7(11)-germacren-8-one CFN98409 32179-18-3 C15H22O3 = 250.3 5mg QQ客服:3257982914
    13-羟基吉马酮; 13-Hydroxygermacrone CFN92648 103994-29-2 C15H22O2 = 234.3 5mg QQ客服:2159513211





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