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  • 吉马酮-4,5-环氧化物

    Germacrone 4,5-epoxide

    吉马酮-4,5-环氧化物
    产品编号 CFN96431
    CAS编号 92691-35-5
    分子式 = 分子量 C15H22O2 = 234.33
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Curcuma phaeocaulis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    吉马酮-4,5-环氧化物 CFN96431 92691-35-5 1mg QQ客服:215959384
    吉马酮-4,5-环氧化物 CFN96431 92691-35-5 5mg QQ客服:215959384
    吉马酮-4,5-环氧化物 CFN96431 92691-35-5 10mg QQ客服:215959384
    吉马酮-4,5-环氧化物 CFN96431 92691-35-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Madras (India)
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  • Institute of Pathophysiology Medical University of Vienna (Austria)
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  • University of Cincinnati (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Ginseng Research2021, 25 November
  • Vojnosanit Pregl2016, 75(00):391-391
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Antiviral Res.2021, 193:105142.
  • Nat Plants.2016, 3:16205
  • Oncol Rep.2021, 46(1):143.
  • Oncol Lett.2020, 20(4):122.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Front Pharmacol.2016, 7:460
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Int J Biol Macromol.2019, 126:653-661
  • Journal of Ginseng Research2022, j.jgr.2022.09.005.
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Front Pharmacol.2019, 10:1355
  • Biochemistry.2018, 57(40):5886-5896
  • Int J Mol Sci.2021, 22(9):5012.
  • Appl. Sci. 2021, 11(10),4666.
  • J Nat Med.2021, doi: 10.1007.
  • Food Chem.2021, 337:128023.
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Int J Mol Sci.2017, 18(12)
  • Pharmaceutics.2020, 12(9):845.
  • Antioxidants (Basel).2021, 10(10):1620.
  • ...
  • 生物活性
    Description: (4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
    Targets: P450 (e.g. CYP17) | IL Receptor | gp120/CD4 | IFN-γ
    In vitro:
    Chem Biodivers. 2014 Jul;11(7):1034-41.
    Suppression of Inflammatory cytokine production by ar-Turmerone isolated from Curcuma phaeocaulis.[Pubmed: 25044589 ]
    Rhizomes of Curcuma phaeocaulis Valeton (Zingiberaceae) have traditionally been used for controlling inflammatory conditions. Numerous studies have aimed to isolate and characterize the bioactive constituents of C. phaeocaulis. It has been reported that its anti-inflammatory properties are a result of cyclooxygenase-2 inhibition; however, its effect on the T-cell function remains to be elucidated.
    METHODS AND RESULTS:
    In this study, four known sesquiterpenoids, viz., ar-turmerone (TM), germacrone (GM), (+)-(4S,5S)-Germacrone 4,5-epoxide (GE), and curzerenone (CZ), were isolated from C. phaeocaulis rhizomes and evaluated for their effects on the CD4(+) T-cell function. While GM, GE, and CZ had no effect on the activation of splenic T cells or CD4(+) T cells, TM suppressed the interferon (IFN)-γ production, without affecting the interleukin (IL)-4 expression. TM also decreased the expression of IL-2 in CD4(+) T cells, but did not change their cell-division rates upon stimulation.
    CONCLUSIONS:
    These results suggest that TM, a major constituent of C. phaeocaulis rhizomes selectively exerts potent anti-inflammatory effects via suppression of the inflammatory cytokines IFN-γ and IL-2.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2675 mL 21.3374 mL 42.6749 mL 85.3497 mL 106.6872 mL
    5 mM 0.8535 mL 4.2675 mL 8.535 mL 17.0699 mL 21.3374 mL
    10 mM 0.4267 mL 2.1337 mL 4.2675 mL 8.535 mL 10.6687 mL
    50 mM 0.0853 mL 0.4267 mL 0.8535 mL 1.707 mL 2.1337 mL
    100 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8535 mL 1.0669 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4(15),5,10(14)-大根香叶三烯-1-醇; 4(15),5,10(14)-Germacratrien-1-ol CFN97301 81968-62-9 C15H24O = 220.4 5mg QQ客服:1457312923
    前异菖蒲烯二醇; Preisocalamendiol CFN98286 25645-19-6 C15H24O = 220.4 5mg QQ客服:2159513211
    莪术二酮; Curdione CFN99146 13657-68-6 C15H24O2 = 236.34 20mg QQ客服:2159513211
    吉马酮; Germacrone CFN98133 6902-91-6 C15H22O = 218.34 20mg QQ客服:2056216494
    吉马酮-4,5-环氧化物; Germacrone 4,5-epoxide CFN96431 92691-35-5 C15H22O2 = 234.33 5mg QQ客服:3257982914
    1,10:4,5-二环氧-7(11)-吉玛烯-8-酮; 1,10:4,5-Diepoxy-7(11)-germacren-8-one CFN98409 32179-18-3 C15H22O3 = 250.3 5mg QQ客服:2159513211
    13-羟基吉马酮; 13-Hydroxygermacrone CFN92648 103994-29-2 C15H22O2 = 234.3 5mg QQ客服:1457312923

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