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  • 13-羟基吉马酮

    13-Hydroxygermacrone

    13-羟基吉马酮
    产品编号 CFN92648
    CAS编号 103994-29-2
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma zedoaria
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    13-羟基吉马酮 CFN92648 103994-29-2 1mg QQ客服:1457312923
    13-羟基吉马酮 CFN92648 103994-29-2 5mg QQ客服:1457312923
    13-羟基吉马酮 CFN92648 103994-29-2 10mg QQ客服:1457312923
    13-羟基吉马酮 CFN92648 103994-29-2 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite Libre de Bruxelles (Belgium)
  • St. Jude Children Research Hospital (USA)
  • Universidad Industrial de Santander (Colombia)
  • Complutense University of Madrid (Spain)
  • Aveiro University (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Mol Cells.2018, 41(8):771-780
  • Nutr Res Pract.2020, 14(5):478-489.
  • Toxicol Mech Methods.2021, 1-12.
  • Institute of Food Science & Technology2021, 45(9).
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Molecules.2022, 27(19):6681.
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Molecules.2019, 24(10):E1926
  • bioRxiv - Molecular Biology2023, 535548.
  • Chemistry of Natural Compounds2020, 56,423-426
  • Molecules.2022, 27(22):7997.
  • BMC Complement Altern Med.2017, 17(1):393
  • J Biomol Struct Dyn.2022, 1-21.
  • Molecules.2023, 28(8):3503.
  • Molecules 2022, 27(3),1047.
  • Exp Parasitol.2018, 194:67-78
  • Phytomedicine.2024, 129:155645.
  • Journal of Life Science2017, 233-240
  • Kor. J. Herbol.2019, 34(2):59-66
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Biochem Pharmacol.2017, 130:10-20
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • ...
  • 生物活性
    Description: 13-Hydroxygermacrone inhibits UVB-induced upregulation of the mRNA and protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes (HaCaT). 13-Hydroxygermacrone shows a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.
    Targets: MMP(e.g.TIMP) | TNF-α
    In vitro:
    Arch Pharm Res. 2015 Oct;38(10):1752-60.
    Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes.[Pubmed: 25471012]

    METHODS AND RESULTS:
    Four sesquiterpenes were isolated from the rhizome of Curcuma xanthorrhiza Roxb.: furanodiene (1), germacrone (2), furanodienone (3), and 13-Hydroxygermacrone (4). Importantly, this was the first time compounds 1 and 13-Hydroxygermacrone were isolated from this plant. The chemical structures of these compounds were determined using 1D- and 2D-nuclear magnetic resonance, infrared spectroscopy, and electron ionization mass spectrometry analyses.
    CONCLUSIONS:
    Among the isolated compounds, compounds 2 and 13-Hydroxygermacrone inhibited UVB-induced upregulation of the mRNA and protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes (HaCaT). Moreover, this upregulation occurred in a dose-dependent manner over the range of 1-10 μM for each compound.
    Nat Prod Res. 2006 Jun;20(7):680-5.
    Anti-inflammatory sesquiterpenes from Curcuma zedoaria.[Pubmed: 16901812]

    METHODS AND RESULTS:
    From the methanolic extract of the rhizome of Curcuma zedoaria, we isolated anti-inflammatory sesquiterpene furanodiene (1) and furanodienone (2) along with new sesquiterpene compound 3 and known eight sesquiterpenes, zederone (4), curzerenone (5), curzeone (6), germacrone (7), 13-Hydroxygermacrone (8), dehydrocurdione (9), curcumenone (10), and zedoaronediol (11). Their structures were elucidated on the basis of spectroscopic data. The anti-inflammatory effect of isolated components on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears were examined.
    CONCLUSIONS:
    Compounds 1 and 2 suppressed the TPA-induced inflammation of mouse ears by 75% and 53%, respectively, at a dose of 1.0 micromol. Their activities are comparable to that of indomethacin, the normally used anti-inflammatory agent.
    In vivo:
    Biol Pharm Bull. 2002 May;25(5):627-31.
    Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha.[Pubmed: 12033504]
    The 80% aqueous acetone extract of Zedoariae Rhizoma was found to show a protective effect against D-galactosamine (D-GalN)/lipopolysaccharide-induced acute liver injury in mice.
    METHODS AND RESULTS:
    To clarify the active compounds, the principal constituents were examined and 11 sesquiterpenes (furanodiene, curdione, neocurdrione, dehydrocurdione, germacrone, 13-Hydroxygermacrone, curcumenol, isocurcumenol, aerugidiol, zedoarondiol, and curcumenone) and a diarylheptanoid (curcumin) were found to inhibit the increase in serum aspartate aminotransaminase and alanine aminotransaminase at a dose of 50 mg/kg p.o. in agreement with the previous in vitro studies, except for dehydrocurdione, aerugidiol, and zedoarondiol. In particular, curdione, neocurdione, curcumenol, and isocurcumenol potently inhibited the increase at a dose of 12.5 mg/kg p.o. Furthermore, the eight sesquiterpenes, furanodiene, curdione, neocurdione, dehydrocurdione, germacrone, 13-Hydroxygermacrone, curcumenol, and curcumenone, also showed a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4(15),5,10(14)-大根香叶三烯-1-醇; 4(15),5,10(14)-Germacratrien-1-ol CFN97301 81968-62-9 C15H24O = 220.4 5mg QQ客服:2159513211
    前异菖蒲烯二醇; Preisocalamendiol CFN98286 25645-19-6 C15H24O = 220.4 5mg QQ客服:3257982914
    莪术二酮; Curdione CFN99146 13657-68-6 C15H24O2 = 236.34 20mg QQ客服:1457312923
    吉马酮; Germacrone CFN98133 6902-91-6 C15H22O = 218.34 20mg QQ客服:2159513211
    吉马酮-4,5-环氧化物; Germacrone 4,5-epoxide CFN96431 92691-35-5 C15H22O2 = 234.33 5mg QQ客服:2159513211
    1,10:4,5-二环氧-7(11)-吉玛烯-8-酮; 1,10:4,5-Diepoxy-7(11)-germacren-8-one CFN98409 32179-18-3 C15H22O3 = 250.3 5mg QQ客服:2159513211
    13-羟基吉马酮; 13-Hydroxygermacrone CFN92648 103994-29-2 C15H22O2 = 234.3 5mg QQ客服:2159513211

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