Info: Read More
  • 中药标准品生产商,产品定制服务
  • 13-羟基吉马酮

    13-Hydroxygermacrone

    13-羟基吉马酮
    产品编号 CFN92648
    CAS编号 103994-29-2
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma zedoaria
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    13-羟基吉马酮 CFN92648 103994-29-2 1mg QQ客服:3257982914
    13-羟基吉马酮 CFN92648 103994-29-2 5mg QQ客服:3257982914
    13-羟基吉马酮 CFN92648 103994-29-2 10mg QQ客服:3257982914
    13-羟基吉马酮 CFN92648 103994-29-2 20mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
  • University of Perugia (Italy)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Sapienza University of Rome (Italy)
  • CSIRO - Agriculture Flagship (Australia)
  • Istanbul University (Turkey)
  • Massachusetts General Hospital (USA)
  • Uniwersytet Gdański (Poland)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Universidad Industrial de Santander (Colombia)
  • University of Melbourne (Australia)
  • University of South Australia (Australia)
  • Universidad Veracuzana (Mexico)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biol Pharm Bull.2020, 43(10):1534-1541.
  • Spectrochim Acta A2019, 210:372-380
  • Molecules2022, 27(11):3606.
  • Planta Med.2018, 84(6-07):465-474
  • Appl. Sci. 2021, 11(22), 10552
  • Applied Biological Chemistry2021, 64(4)
  • Antioxidants (Basel).2021, 10(10):1638.
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Molecules.2019, 24(10):E1930
  • Plants (Basel).2023, 12(1):163.
  • Molecules.2019, 24(7):E1290
  • Sci Rep.2017, 7:46299
  • Analytical Methods2018, 10(27)
  • Acta Agriculturae Scandinavica2015, 381-383
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Molecules 2022, 27(3),1047.
  • Kor. J. Herbol.2019, 34(2):59-66
  • Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
  • Fitoterapia.2015, 100:179-86
  • J Ginseng Res.2022, 46(1):104-114.
  • Biomolecules2021, 11(10),1513.
  • Toxins (Basel).2020, 12(4):210.
  • Research on Crops.2017, 18(3):569
  • ...
  • 生物活性
    Description: 13-Hydroxygermacrone inhibits UVB-induced upregulation of the mRNA and protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes (HaCaT). 13-Hydroxygermacrone shows a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.
    Targets: MMP(e.g.TIMP) | TNF-α
    In vitro:
    Arch Pharm Res. 2015 Oct;38(10):1752-60.
    Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes.[Pubmed: 25471012]

    METHODS AND RESULTS:
    Four sesquiterpenes were isolated from the rhizome of Curcuma xanthorrhiza Roxb.: furanodiene (1), germacrone (2), furanodienone (3), and 13-Hydroxygermacrone (4). Importantly, this was the first time compounds 1 and 13-Hydroxygermacrone were isolated from this plant. The chemical structures of these compounds were determined using 1D- and 2D-nuclear magnetic resonance, infrared spectroscopy, and electron ionization mass spectrometry analyses.
    CONCLUSIONS:
    Among the isolated compounds, compounds 2 and 13-Hydroxygermacrone inhibited UVB-induced upregulation of the mRNA and protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes (HaCaT). Moreover, this upregulation occurred in a dose-dependent manner over the range of 1-10 μM for each compound.
    Nat Prod Res. 2006 Jun;20(7):680-5.
    Anti-inflammatory sesquiterpenes from Curcuma zedoaria.[Pubmed: 16901812]

    METHODS AND RESULTS:
    From the methanolic extract of the rhizome of Curcuma zedoaria, we isolated anti-inflammatory sesquiterpene furanodiene (1) and furanodienone (2) along with new sesquiterpene compound 3 and known eight sesquiterpenes, zederone (4), curzerenone (5), curzeone (6), germacrone (7), 13-Hydroxygermacrone (8), dehydrocurdione (9), curcumenone (10), and zedoaronediol (11). Their structures were elucidated on the basis of spectroscopic data. The anti-inflammatory effect of isolated components on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears were examined.
    CONCLUSIONS:
    Compounds 1 and 2 suppressed the TPA-induced inflammation of mouse ears by 75% and 53%, respectively, at a dose of 1.0 micromol. Their activities are comparable to that of indomethacin, the normally used anti-inflammatory agent.
    In vivo:
    Biol Pharm Bull. 2002 May;25(5):627-31.
    Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha.[Pubmed: 12033504]
    The 80% aqueous acetone extract of Zedoariae Rhizoma was found to show a protective effect against D-galactosamine (D-GalN)/lipopolysaccharide-induced acute liver injury in mice.
    METHODS AND RESULTS:
    To clarify the active compounds, the principal constituents were examined and 11 sesquiterpenes (furanodiene, curdione, neocurdrione, dehydrocurdione, germacrone, 13-Hydroxygermacrone, curcumenol, isocurcumenol, aerugidiol, zedoarondiol, and curcumenone) and a diarylheptanoid (curcumin) were found to inhibit the increase in serum aspartate aminotransaminase and alanine aminotransaminase at a dose of 50 mg/kg p.o. in agreement with the previous in vitro studies, except for dehydrocurdione, aerugidiol, and zedoarondiol. In particular, curdione, neocurdione, curcumenol, and isocurcumenol potently inhibited the increase at a dose of 12.5 mg/kg p.o. Furthermore, the eight sesquiterpenes, furanodiene, curdione, neocurdione, dehydrocurdione, germacrone, 13-Hydroxygermacrone, curcumenol, and curcumenone, also showed a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4(15),5,10(14)-大根香叶三烯-1-醇; 4(15),5,10(14)-Germacratrien-1-ol CFN97301 81968-62-9 C15H24O = 220.4 5mg QQ客服:3257982914
    前异菖蒲烯二醇; Preisocalamendiol CFN98286 25645-19-6 C15H24O = 220.4 5mg QQ客服:1457312923
    莪术二酮; Curdione CFN99146 13657-68-6 C15H24O2 = 236.34 20mg QQ客服:1413575084
    吉马酮; Germacrone CFN98133 6902-91-6 C15H22O = 218.34 20mg QQ客服:3257982914
    吉马酮-4,5-环氧化物; Germacrone 4,5-epoxide CFN96431 92691-35-5 C15H22O2 = 234.33 5mg QQ客服:2159513211
    1,10:4,5-二环氧-7(11)-吉玛烯-8-酮; 1,10:4,5-Diepoxy-7(11)-germacren-8-one CFN98409 32179-18-3 C15H22O3 = 250.3 5mg QQ客服:215959384
    13-羟基吉马酮; 13-Hydroxygermacrone CFN92648 103994-29-2 C15H22O2 = 234.3 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产