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  • 富马酸,反丁烯二酸

    Fumaric acid

    富马酸,反丁烯二酸
    产品编号 CFN99201
    CAS编号 110-17-8
    分子式 = 分子量 C4H4O4 = 116.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The herbs of Fumaria officinalis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    富马酸,反丁烯二酸 CFN99201 110-17-8 10mg QQ客服:3257982914
    富马酸,反丁烯二酸 CFN99201 110-17-8 20mg QQ客服:3257982914
    富马酸,反丁烯二酸 CFN99201 110-17-8 50mg QQ客服:3257982914
    富马酸,反丁烯二酸 CFN99201 110-17-8 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Indonesia (Indonesia)
  • University of Hull (United Kingdom)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Semmelweis Unicersity (Hungary)
  • Celltrion Chemical Research Institute (Korea)
  • Korea Food Research Institute(KFRI) (Korea)
  • Kitasato University (Japan)
  • Utah State University (USA)
  • Hamdard University (India)
  • Northeast Normal University Changchun (China)
  • Monash University (Australia)
  • Universidade Federal de Santa Catarina (Brazil)
  • Imperial College London (United Kingdom)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacol Rep.2019, 71(2):289-298
  • Mol Pharmacol.2021, 99(2):163-174.
  • Int J Anal Chem.2017, 2017:1254721
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Molecules.2019, 24(4):E744
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • JEJU National University2022, 24032.
  • Oxid Med Cell Longev2019, 9056845:13
  • Bulletin of Health Research2016, 44(4):279-286
  • ACS Omega2020, 5,33,20825-20830
  • Nat Commun.2021, 12(1):681.
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Journal of Ginseng Research2021, 15 June.
  • Anticancer Res.2021, 41(3):1357-1364.
  • Journal of Functional Foods2019, 52:430-441
  • Chem Biol Interact.2019, 298:1-7
  • Current Pharmaceutical Analysis2017, 13(5)
  • Front Pharmacol.2021, 12:635510.
  • University of Limpopo2016, 1-237
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Natural Product Communications2020, doi: 10.1177.
  • Green Chemistry2021, ISSUE 2.
  • ...
  • 生物活性
    Description: Fumaric acid is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle. Fumaric acid is used in systemic and topical treatment of psoriasis. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling.
    Targets: TNF-α | NF-kB | p38MAPK
    In vitro:
    Biotechnol Bioeng. 2013 Jul;110(7):2025-34.
    Metabolic engineering of Escherichia coli for the production of fumaric acid.[Pubmed: 23436277]

    METHODS AND RESULTS:
    In this study, Escherichia coli was metabolically engineered for the production of Fumaric acid under aerobic condition. For the aerobic production of Fumaric acid, the iclR gene was deleted to redirect the carbon flux through the glyoxylate shunt. In addition, the fumA, fumB, and fumC genes were also deleted to enhance Fumaric acid formation. The resulting strain was able to produce 1.45 g/L of Fumaric acid from 15 g/L of glucose in flask culture. Based on in silico flux response analysis, this base strain was further engineered by plasmid-based overexpression of the native ppc gene, encoding phosphoenolpyruvate carboxylase (PPC), from the strong tac promoter, which resulted in the production of 4.09 g/L of Fumaric acid. Additionally, the arcA and ptsG genes were deleted to reinforce the oxidative TCA cycle flux, and the aspA gene was deleted to block the conversion of Fumaric acid into L-aspartic acid. Since it is desirable to avoid the use of inducer, the lacI gene was also deleted. To increase glucose uptake rate and Fumaric acid productivity, the native promoter of the galP gene was replaced with the strong trc promoter. Fed-batch culture of the final strain CWF812 allowed production of 28.2 g/L Fumaric acid in 63 h with the overall yield and productivity of 0.389 g Fumaric acid/g glucose and 0.448 g/L/h, respectively.
    CONCLUSIONS:
    This study demonstrates the possibility for the efficient production of Fumaric acid by metabolically engineered E. coli.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 8.6133 mL 43.0663 mL 86.1326 mL 172.2653 mL 215.3316 mL
    5 mM 1.7227 mL 8.6133 mL 17.2265 mL 34.4531 mL 43.0663 mL
    10 mM 0.8613 mL 4.3066 mL 8.6133 mL 17.2265 mL 21.5332 mL
    50 mM 0.1723 mL 0.8613 mL 1.7227 mL 3.4453 mL 4.3066 mL
    100 mM 0.0861 mL 0.4307 mL 0.8613 mL 1.7227 mL 2.1533 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-甲氧基丙烯酸甲酯; Methyl 3-methoxyacrylate CFN90112 34846-90-7 C5H8O3 = 116.12 100mg QQ客服:1148253675
    乙酰丙酸甲酯; Methyl levulinate CFN97077 624-45-3 C6H10O3 = 130.1 100mg QQ客服:1413575084
    琥珀酸; 丁二酸; Succinic acid CFN99100 110-15-6 C4H6O4 = 118.1 20mg QQ客服:1148253675
    富马酸,反丁烯二酸; Fumaric acid CFN99201 110-17-8 C4H4O4 = 116.1 20mg QQ客服:215959384
    苹果酸; Malic acid CFN90558 6915-15-7 C4H6O5 = 134.09 20mg QQ客服:3257982914
    苹果酸 4-甲酯; Malic acid 4-Me ester CFN97130 66178-02-7 C5H8O5 = 148.1 5mg QQ客服:215959384
    酒石酸; Tartaric acid CFN93181 87-69-4 C4H6O6 = 150.09 5mg QQ客服:1148253675
    柠檬酸; Citric acid CFN98551 77-92-9 C6H8O7 = 192.12 20mg QQ客服:3257982914
    羟基柠檬酸; Hydroxycitric acid CFN90798 6205-14-7 C6H8O8 = 208.12 5mg QQ客服:1413575084
    甘露醇; Mannitol CFN93001 87-78-5 C6H14O6 = 182.17 20mg QQ客服:1413575084

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