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  • 苹果酸

    Malic acid

    苹果酸
    产品编号 CFN90558
    CAS编号 6915-15-7
    分子式 = 分子量 C4H6O5 = 134.09
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The herbs of Scutellaria barbata D. Don.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    苹果酸 CFN90558 6915-15-7 10mg QQ客服:2056216494
    苹果酸 CFN90558 6915-15-7 20mg QQ客服:2056216494
    苹果酸 CFN90558 6915-15-7 50mg QQ客服:2056216494
    苹果酸 CFN90558 6915-15-7 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Madras (India)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Anna University (India)
  • Shanghai University of TCM (China)
  • University of Stirling (United Kingdom)
  • Center for protein Engineering (CIP) (Belgium)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Int Immunopharmacol. 2020, 83:106403.
  • University of Central Lancashire2017, 20472
  • Food Funct.2024, 15(8):4262-4275.
  • Food Analytical Methods2020, 1-10
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Biomed Pharmacother.2023, 163:114785.
  • Data Science for Genomics2023, 107-128.
  • Phytomedicine.2018, 38:12-23
  • J Ethnopharmacol.2017, 198:87-90
  • Eur J Pharmacol.2022, 917:174744.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Journal of Applied Biology & Biotechnology2023,11(4):148-158
  • Front Chem.2024, 12:1385844.
  • Functional Ecology2020, doi: 10.1111.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • Food Funct.2020, 11(2):1322-1333.
  • Int J Mol Sci.2022, 23(21):13406.
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Evid-Based Compl Alt2020, 7202519:13
  • Industrial Crops and Products2017, 95:286-295
  • ...
  • 生物活性
    Description: Malic acid is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods. Malic acid supplementation may be useful for conservative treatment of calcium renal stone disease by virtue of its capacity to induce these effects.
    Targets: Calcium Channel
    In vitro:
    Poult Sci. 2013 Jul;92(7):1936-41.
    Efficacy of malic acid against Listeria monocytogenes attached to poultry skin during refrigerated storage.[Pubmed: 23776283]
    This work evaluated the effect of malic acid washing on the growth of Listeria monocytogenes on poultry legs stored at 4°C for 8 d.
    METHODS AND RESULTS:
    Fresh inoculated chicken legs were dipped into a 1 or 2% malic acid solution (vol/vol) for 5 min or distilled water (control). Surface pH values, sensorial characteristics (odor, color, texture, and overall appearance) and L. monocytogenes, mesophile, psychrotroph, and Enterobacteriaceae counts were evaluated after treatment (d 0) and after 1, 3, 6, and 8 d of storage at 4°C. Legs washed with 2% malic acid showed a significant (P < 0.05) inhibitory effect on L. monocytogenes compared with control legs, with a decrease of about 1.66 log units after treatment. Sensory quality was not adversely affected by malic acid. Treatments with malic acid reduced bacterial growth and preserved reasonable sensorial quality after storage at 4°C for 6 d.
    CONCLUSIONS:
    This study demonstrates that, although malic acid did reduce populations of L. monocytogenes on poultry, it did not completely inactivate the pathogen. The application of malic acid may be used as an additional hurdle contributing to extend the shelf life of raw poultry.
    Bioresour Technol . 2018 Jun;258:345-353.
    Current advance in biological production of malic acid using wild type and metabolic engineered strains[Pubmed: 29550171]
    Abstract Malic acid (2-hydroxybutanedioic acid) is a four-carbon dicarboxylic acid, which has attracted great interest due to its wide usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Several mature routes for malic acid production have been developed, such as chemical synthesis, enzymatic conversion and biological fermentation. With depletion of fossil fuels and concerns regarding environmental issues, biological production of malic acid has attracted more attention, which mainly consists of three pathways, namely non-oxidative pathway, oxidative pathway and glyoxylate cycle. In recent decades, metabolic engineering of model strains, and process optimization for malic acid production have been rapidly developed. Hence, this review comprehensively introduces an overview of malic acid producers and highlight some of the successful metabolic engineering approaches. Keywords: Biosynthesis; Carbon dioxide; Metabolic engineering; Renewable resources; l-Malic acid. Copyright © 2018 Elsevier Ltd. All rights reserved.
    In vivo:
    J Endourol. 2014 Feb;28(2):229-36.
    Malic acid supplementation increases urinary citrate excretion and urinary pH: implications for the potential treatment of calcium oxalate stone disease.[Pubmed: 24059642]
    Raising urinary pH and citrate excretion with alkali citrate therapy has been a widely used treatment in calcium nephrolithiasis. Citrate lowers ionized Ca(+2) concentrations and inhibits calcium salt precipitation. Conservative alternatives containing citrate such as fruit juices have been investigated and recommended. Any compound that induces systemic alkalosis will increase citraturia. Malate, a polycarboxylic anion like citrate, is a potential candidate for chelating Ca(+2) and for inducing systemic alkalinization. We undertook to investigate these possibilities.
    METHODS AND RESULTS:
    Theoretical modeling of malic acid's effects on urinary Ca(+2) concentration and supersaturation (SS) of calcium salts was achieved using the speciation program JESS. Malic acid (1200 mg/day) was ingested for 7 days by eight healthy subjects. Urines (24 hours) were collected at baseline and on day 7. They were analyzed for routine lithogenic components, including pH and citrate. Chemical speciation and SS were calculated in both urines. Modeling showed that complexation between calcium and malate at physiological concentrations of the latter would have no effect on SS. Administration of the supplement induced statistically significant increases in pH and citraturia. The calculated concentration of Ca(+2) and concomitant SS calcium oxalate (CaOx) decreased after supplementation, but these were not statistically significant. SS for the calcium phosphate salts hydroxyapatite and tricalcium phosphate increased significantly as a consequence of the elevation in pH, but values for brushite and octacalcium phosphate did not change significantly.
    CONCLUSIONS:
    We speculate that consumption of malic acid induced systemic alkalinization leading to reduced renal tubular reabsorption and metabolism of citrate, and an increase in excretion of the latter. The decrease in SS(CaOx) was caused by enhanced complexation of Ca(+2) by citrate. We conclude that malic acid supplementation may be useful for conservative treatment of calcium renal stone disease by virtue of its capacity to induce these effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 7.4577 mL 37.2884 mL 74.5768 mL 149.1536 mL 186.4419 mL
    5 mM 1.4915 mL 7.4577 mL 14.9154 mL 29.8307 mL 37.2884 mL
    10 mM 0.7458 mL 3.7288 mL 7.4577 mL 14.9154 mL 18.6442 mL
    50 mM 0.1492 mL 0.7458 mL 1.4915 mL 2.9831 mL 3.7288 mL
    100 mM 0.0746 mL 0.3729 mL 0.7458 mL 1.4915 mL 1.8644 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柠檬酸; Citric acid CFN98551 77-92-9 C6H8O7 = 192.12 20mg QQ客服:1413575084
    柠檬酸三乙酯; Triethyl citrate CFN91520 77-93-0 C12H20O7 = 276.3 20mg QQ客服:3257982914
    羟基柠檬酸; Hydroxycitric acid CFN90798 6205-14-7 C6H8O8 = 208.12 5mg QQ客服:2056216494
    甘露醇; Mannitol CFN93001 87-78-5 C6H14O6 = 182.17 20mg QQ客服:2056216494
    乳胞素; Lactacystin CFN00121 133343-34-7 C15H24N2O7S = 376.43 5mg QQ客服:1413575084
    二氯乙酸钠; Sodium Dichloroacetate CFN90889 2156-56-1 C2HCl2NaO2 = 150.9 20mg QQ客服:1457312923
    当归酸; Angelic acid CFN92466 565-63-9 C5H8O2 = 100.1 20mg QQ客服:3257982914
    当归酸酐; Angelic anhydride CFN92467 94487-74-8 C10H14O3 = 182.2 20mg QQ客服:3257982914
    正丁醇; Butanol CFN98128 71-36-3 C4H10O = 74.12 20mg QQ客服:2159513211
    3-羟基丁酸; 3-Hydroxybutyric acid CFN90053 625-71-8 C4H8O3 = 104.1 5mg QQ客服:1413575084

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