羟基柠檬酸

Hydroxycitric acid

	产品编号	CFN90798
	CAS编号	6205-14-7
	分子式 = 分子量	C₆H₈O₈ = 208.12
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The fruits of Garcinia atroviridis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
羟基柠檬酸	CFN90798	6205-14-7	1mg	QQ客服：2056216494
羟基柠檬酸	CFN90798	6205-14-7	5mg	QQ客服：2056216494
羟基柠檬酸	CFN90798	6205-14-7	10mg	QQ客服：2056216494
羟基柠檬酸	CFN90798	6205-14-7	20mg	QQ客服：2056216494

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Sanford Burnham Medical Research Institute (USA)

CSIRO - Agriculture Flagship (Australia)

MTT Agrifood Research Finland (Finland)

Periyar University (India)

Northeast Normal University Changchun (China)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

John Innes Centre (United Kingdom)

Medical University of South Carolina (USA)

Universiti Kebangsaan Malaysia (Malaysia)

University of Bordeaux (France)

National Research Council of Canada (Canada)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

More...

Description:

(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. Hydroxycitric acid ameliorates high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects.

Targets:

Fatty Acid Synthase | ERK | p38MAPK

In vitro:

Food Chem Toxicol. 2004 Sep;42(9):1513-29.

Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt.[Pubmed: 15234082 ]

METHODS AND RESULTS:
(-)-Hydroxycitric acid (HCA) is a principle constituent (10-30%) of the dried fruit rind of Garcinia cambogia, a plant native to Southeastern Asia. The dried rind has been used for centuries throughout Southeast Asia as a food preservative, flavoring agent and carminative. Extensive experimental studies show that HCA inhibits fat synthesis and reduces food intake.
CONCLUSIONS:
The objective of this review is to systematically review the available safety/toxicity literature on HCA to determine its safety in-use. The primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis.

In vivo:

J Basic Clin Physiol Pharmacol. 2016 Jun 1;27(4):349-56.

Hydroxycitric acid ameliorates high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats.[Pubmed: 26974136 ]

Excess fructose consumption causes dyslipidemia, oxidative stress, and various complications. Hydroxycitric acid (HCA), one of the principal components of the fruit Garcinia cambogia, has been shown to possess antiobesity properties. The objective was to investigate the effects of HCA on redox imbalance and activation of stress sensitive kinases in high fructose-fed rats.
METHODS AND RESULTS:
Male Wistar rats (n=40) were randomly divided into four groups with 10 rats in each group. The rats were fed with either standard rodent diet or 60% fructose diet and administered with HCA at a dose of 400 mg/kg body wt/day for 10 weeks. Body weight was measured once a week, and food intake was noted daily. At the end of the study, lipid profile and oxidative stress parameters were estimated. Expressions of stress sensitive kinases were analyzed in liver homogenates. Fructose-fed rats displayed elevated body weight, higher levels of plasma total cholesterol (TC), triacylglycerol (TAG), non-high-density lipoprotein cholesterol (non HDL-C), malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), lower levels of HDL-C, glutathione (GSH), glutathione peroxidase (GPx), and total antioxidant status (TAS). Fructose feeding caused higher phosphorylation of stress sensitive kinases ERK ½ and p38. Administration with HCA lowered body weight, food intake, TAG, non-HDL-C, MDA, TOS, and OSI and elevated GSH, GPx, and TAS levels. Reduced phosphorylation of ERK ½ and p38 mitogen-activated protein kinase (MAPK) was observed upon HCA treatment.
CONCLUSIONS:
Thus, HCA improved fructose induced redox imbalance and activation of stress sensitive kinases through its hypolipidemic effects.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-甲氧基丙烯酸甲酯; Methyl 3-methoxyacrylate	CFN90112	34846-90-7	C₅H₈O₃ = 116.12	20mg	QQ客服：2159513211
乙酰丙酸甲酯; Methyl levulinate	CFN97077	624-45-3	C₆H₁₀O₃ = 130.1	20mg	QQ客服：1413575084
琥珀酸；丁二酸; Succinic acid	CFN99100	110-15-6	C₄H₆O₄ = 118.1	20mg	QQ客服：3257982914
富马酸,反丁烯二酸; Fumaric acid	CFN99201	110-17-8	C₄H₄O₄ = 116.1	20mg	QQ客服：1413575084
苹果酸; Malic acid	CFN90558	6915-15-7	C₄H₆O₅ = 134.09	20mg	QQ客服：1457312923
苹果酸 4-甲酯; Malic acid 4-Me ester	CFN97130	66178-02-7	C₅H₈O₅ = 148.1	5mg	QQ客服：2056216494
酒石酸; Tartaric acid	CFN93181	87-69-4	C₄H₆O₆ = 150.09	5mg	QQ客服：2159513211
柠檬酸; Citric acid	CFN98551	77-92-9	C₆H₈O₇ = 192.12	20mg	QQ客服：1413575084
柠檬酸三乙酯; Triethyl citrate	CFN91520	77-93-0	C₁₂H₂₀O₇ = 276.3	20mg	QQ客服：2159513211
羟基柠檬酸; Hydroxycitric acid	CFN90798	6205-14-7	C₆H₈O₈ = 208.12	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.8049 mL	24.0246 mL	48.0492 mL	96.0984 mL	120.123 mL
5 mM	0.961 mL	4.8049 mL	9.6098 mL	19.2197 mL	24.0246 mL
10 mM	0.4805 mL	2.4025 mL	4.8049 mL	9.6098 mL	12.0123 mL
50 mM	0.0961 mL	0.4805 mL	0.961 mL	1.922 mL	2.4025 mL
100 mM	0.048 mL	0.2402 mL	0.4805 mL	0.961 mL	1.2012 mL

羟基柠檬酸

Hydroxycitric acid

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