狗牙花碱D乙醚

Coronarin D ethyl ether

	产品编号	CFN99439
	CAS编号	138965-89-6
	分子式 = 分子量	C₂₂H₃₄O₃ = 346.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The rhizomes of Hedychium coronarium
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
狗牙花碱D乙醚	CFN99439	138965-89-6	1mg	QQ客服：1413575084
狗牙花碱D乙醚	CFN99439	138965-89-6	5mg	QQ客服：1413575084
狗牙花碱D乙醚	CFN99439	138965-89-6	10mg	QQ客服：1413575084
狗牙花碱D乙醚	CFN99439	138965-89-6	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Shanghai Institute of Biochemistry and Cell Biology (China)

Universidad de Antioquia (Colombia)

Wroclaw Medical University (Poland)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Calcutta University (India)

University of Illinois at Chicago (USA)

University of South Australia (Australia)

Funda??o Universitária de Desenvolvimento (Brazil)

University of Auckland (New Zealand)

Universiti Sains Malaysia (Malaysia)

Kyung Hee University (Korea)

University of Amsterdam (Netherlands)

Chinese University of Hong Kong (China)

CSIRO - Agriculture Flagship (Australia)

More...

Description:

Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro.

Targets:

NF-KB

In vitro:

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7460-5.

Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells.[Pubmed: 22071304]

The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine.
METHODS AND RESULTS:
From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance spectroscopy. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-α, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19±0.11 to 10.38±2.34 μM. The remains of compounds showed inactivity or due to cytotoxicity.
CONCLUSIONS:
These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
高良姜萜内酯; Galanolactone	CFN99258	115753-79-2	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：2056216494
异姜花素D; Isocoronarin D	CFN99438	138965-88-5	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：3257982914
狗牙花碱D; Coronarin D	CFN99302	119188-37-3	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：3257982914
狗牙花碱D甲醚; Coronarin D methyl ether	CFN99667	157528-81-9	C₂₁H₃₂O₃ = 332.5	5mg	QQ客服：3257982914
狗牙花碱D乙醚; Coronarin D ethyl ether	CFN99439	138965-89-6	C₂₂H₃₄O₃ = 346.5	5mg	QQ客服：2056216494
15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one; 15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one	CFN89136	1374328-47-8	C₂₂H₃₆O₅ = 380.52	5mg	QQ客服：215959384
Hedycoronen A; Hedycoronen A	CFN89375	1383441-73-3	C₂₁H₃₀O₃ = 330.46	5mg	QQ客服：1413575084
Chinensine B; Chinensine B	CFN97409	849245-34-7	C₂₀H₂₈O₃ = 316.4	5mg	QQ客服：3257982914
牡荆内酯; Vitexilactone	CFN97047	61263-49-8	C₂₂H₃₄O₅ = 378.5	5mg	QQ客服：2159513211
12-羟基-8(17),13-赖百当二烯-16,15-内酯; 12-Hydroxy-8(17),13-labdadien-16,15-olide	CFN97538	958885-86-4	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.886 mL	14.43 mL	28.86 mL	57.7201 mL	72.1501 mL
5 mM	0.5772 mL	2.886 mL	5.772 mL	11.544 mL	14.43 mL
10 mM	0.2886 mL	1.443 mL	2.886 mL	5.772 mL	7.215 mL
50 mM	0.0577 mL	0.2886 mL	0.5772 mL	1.1544 mL	1.443 mL
100 mM	0.0289 mL	0.1443 mL	0.2886 mL	0.5772 mL	0.7215 mL