Hedycoronen A

	产品编号	CFN89375
	CAS编号	1383441-73-3
	分子式 = 分子量	C₂₁H₃₀O₃ = 330.46
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The rhizomes of Hedychium coronarium.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Hedycoronen A	CFN89375	1383441-73-3	1mg	QQ客服：1457312923
Hedycoronen A	CFN89375	1383441-73-3	5mg	QQ客服：1457312923
Hedycoronen A	CFN89375	1383441-73-3	10mg	QQ客服：1457312923
Hedycoronen A	CFN89375	1383441-73-3	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Leipzig (Germany)

Technical University of Denmark (Denmark)

Helmholtz Zentrum München (Germany)

University of Eastern Finland (Finland)

Donald Danforth Plant Science Center (USA)

Monash University Sunway Campus (Malaysia)

Universidade Federal de Pernambuco (UFPE) (Brazil)

University of Limpopo (South Africa)

Imperial College London (United Kingdom)

Nanjing University of Chinese Medicine (China)

National Chung Hsing University (Taiwan)

Instituto de Investigaciones Agropecuarias (Chile)

University of Lodz (Poland)

University of Otago (New Zealand)

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Description:

Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 uM, they also show moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC(50) values of 46.0±1.3 and 12.7±0.3 uM.

Targets:

TNF-α | IL Receptor

In vitro:

Chem Pharm Bull (Tokyo). 2012;60(2):246-50.

Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.[Pubmed: 22293485]

The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine.
METHODS AND RESULTS:
From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named Hedycoronen A and hedycoronen B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1-3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 μM. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC(50) values of 46.0±1.3 and 12.7±0.3 μM. The remains of compounds showed inactivity.
CONCLUSIONS:
These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
狗牙花碱D甲醚; Coronarin D methyl ether	CFN99667	157528-81-9	C₂₁H₃₂O₃ = 332.5	5mg	QQ客服：2159513211
狗牙花碱D乙醚; Coronarin D ethyl ether	CFN99439	138965-89-6	C₂₂H₃₄O₃ = 346.5	5mg	QQ客服：2159513211
15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one; 15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one	CFN89136	1374328-47-8	C₂₂H₃₆O₅ = 380.52	5mg	QQ客服：1413575084
Hedycoronen A; Hedycoronen A	CFN89375	1383441-73-3	C₂₁H₃₀O₃ = 330.46	5mg	QQ客服：2159513211
Chinensine B; Chinensine B	CFN97409	849245-34-7	C₂₀H₂₈O₃ = 316.4	5mg	QQ客服：3257982914
牡荆内酯; Vitexilactone	CFN97047	61263-49-8	C₂₂H₃₄O₅ = 378.5	5mg	QQ客服：1457312923
12-羟基-8(17),13-赖百当二烯-16,15-内酯; 12-Hydroxy-8(17),13-labdadien-16,15-olide	CFN97538	958885-86-4	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：1457312923
Villosin; Villosin	CFN99674	160598-92-5	C₂₀H₂₈O₂ = 300.4	5mg	QQ客服：215959384
高良姜萜内酯; Galanolactone	CFN99258	115753-79-2	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：3257982914
异姜花素D; Isocoronarin D	CFN99438	138965-88-5	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0261 mL	15.1304 mL	30.2608 mL	60.5217 mL	75.6521 mL
5 mM	0.6052 mL	3.0261 mL	6.0522 mL	12.1043 mL	15.1304 mL
10 mM	0.3026 mL	1.513 mL	3.0261 mL	6.0522 mL	7.5652 mL
50 mM	0.0605 mL	0.3026 mL	0.6052 mL	1.2104 mL	1.513 mL
100 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.6052 mL	0.7565 mL