| Description: |
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi; using coronarin D-antibiotic drug combination can combat the infectious diseases.Coronarin D inhibits NF-kappaB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis. |
| In vitro: |
| Biomed Res Int. 2014;2014:581985. | | Antimicrobial activity of coronarin D and its synergistic potential with antibiotics.[Pubmed: 24949458] | Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium. In the view of our ongoing effort to explore its novel biological activity, antimicrobial activity study of Coronarin D was performed.
METHODS AND RESULTS:
The results showed that Coronarin D was active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi. The antibacterial effect of the combination of Coronarin D with nine classical antibiotics against four Gram-positive bacteria was also evaluated. The fractional inhibitory concentration indices (FICI) of Coronarin D-antibiotics combinations, calculated from the checkerboard assay, were used as synergism indicator. Out of 36 combinations, 47% showed total synergism, 33% had partial synergistic interaction, 17% showed no effect, and 3% showed antagonism. By combination with Coronarin D at concentration of 0.25 minimal inhibitory concentration (MIC), the activities of antibiotics were boosted to 4- to 128-fold.
CONCLUSIONS:
These finding suggested an attractive approach to combat the infectious diseases by using Coronarin D-antibiotic drug combination. | | Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jul;114(1):61-6. | | Antifungal activity of coronarin D against Candida albicans.[Pubmed: 22727093] | The objective of this study was to investigate the antifungal activity of Coronarin D on Candida albicans and its activity was compared with clotrimazole and nystatin.
METHODS AND RESULTS:
Coronarin D was extracted by liquid chromatography and used in antifungal testing. The inhibitory effect of Coronarin D on C. albicans was determined by cultures and an applied broth dilution test. The rate of fungicidal activity was evaluated by time-kill curves. Morphologic alterations of fungal cells were investigated using scanning electron microscopy. Coronarin D was effective against C. albicans; the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively. The C. albicans killing activity of Coronarin D was higher than clotrimazole and nystatin at 2 × MFC and 4 × MFC, respectively. Morphologic alterations of fungal cells consistent with cell membrane damage were observed in the Coronarin D-treated cells.
CONCLUSIONS:
Coronarin D showed promising antifungal activity against C. albicans in vitro. |
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