Info: Read More
  • 中药标准品生产商,产品定制服务
  • 木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮

    Cajanin

    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮
    产品编号 CFN98419
    CAS编号 32884-36-9
    分子式 = 分子量 C16H12O6 = 300.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Kadsura interior
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮 CFN98419 32884-36-9 1mg QQ客服:3257982914
    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮 CFN98419 32884-36-9 5mg QQ客服:3257982914
    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮 CFN98419 32884-36-9 10mg QQ客服:3257982914
    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮 CFN98419 32884-36-9 20mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Donald Danforth Plant Science Center (USA)
  • Charles Sturt University (Denmark)
  • University of Parma (Italy)
  • University of Helsinki (Finland)
  • China Medical University (Taiwan)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Hamdard University (India)
  • University of Lodz (Poland)
  • Stanford University (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • National Hellenic Research Foundation (Greece)
  • National Cancer Center Research Institute (Japan)
  • University of Hawaii Cancer Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Universidade Estadual Paulista2017, 42785
  • Front Microbiol.2022, 13:835463.
  • Microchemical Journal2023. 191:108938
  • Tumour Biol.2015, 36(12):9385-93
  • Appl. Sci. 2021, 11(1),14.
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • Molecules.2020, 25(3):734
  • Journal of Food Quality2022, P:13, 6256310.
  • Biomed Sci Letters.2020, 26:319-326
  • Analytical methods2019, 11(6)
  • Agriculture.2022, 12(3), 342.
  • Mol Cell.2017, 68(4):673-685
  • Food Chem.2017, 228:301-314
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Pak J Pharm Sci.2019, 32(6)
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Fitoterapia.2021, 153:104995.
  • Molecules.2019, 24(19):E3417
  • Cell Rep.2022, 39(1):110643.
  • Agronomy2023, 13(6), 1435.
  • Sci Rep.2017, 7:467-479
  • ...
  • 生物活性
    Description: Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. Cajanin has strong mitogenic as well as differentiation-promoting effects on osteoblasts that involved subsequent activation of MEK-Erk and Akt pathways.
    Targets: MEK | ERK | Akt | ABCA1
    In vitro:
    Planta Med. 2010 Jan;76(1):79-81.
    Flavonoids and isoflavonoids from Sophorae Flos improve glucose uptake in vitro.[Pubmed: 19637114 ]

    METHODS AND RESULTS:
    Glucose uptake assay-guided fractionations on the methanol extract of Sophorae Flos led to the isolation of the flavonoids rutin (1), narcissin (2), quercetin (3), tamarixetin (4), and kaempferol (5) and the isoflavonoids Cajanin (6), genistein (7), orobol (8), and pratensein (9). Among them, 1, 4, 5, 6, 8, and 9 significantly improved basal glucose uptake in HepG2 cells. Their improving effects were concentration dependent. Compounds 4, 5, 6, and 9 exhibited effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. However, 2, 3, and 7 did not show any improving effects. Stimulating glucose uptake into peripheral cells may be responsible for reducing the level of blood glucose in the circulation.
    CONCLUSIONS:
    Therefore, these findings demonstrate a potential to develop these flavonoids and isoflavonoids as hypoglycemic drugs.
    In vivo:
    J Cell Biochem. 2009 Oct 1;108(2):388-99.
    Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling.[Pubmed: 19598169]
    Following a lead obtained from stem-bark extract of Butea monosperma, two structurally related methoxyisoflavones; cajanin and isoformononetin were studied for their effects in osteoblasts.
    METHODS AND RESULTS:
    Cajanin had strong mitogenic as well as differentiation-promoting effects on osteoblasts that involved subsequent activation of MEK-Erk and Akt pathways. On the other hand, isoformononetin exhibited potent anti-apoptotic effect in addition to promoting osteoblast differentiation that involved parallel activation of MEK-Erk and Akt pathways. Unlike genistein or daidzein, none of these two compounds appear to act via estrogen receptors in osteoblast. Once daily oral (by gavage) treatment for 30 consecutive days was given to recently weaned female Sprague-Dawley rats with each of these compounds at 10.0 mg kg(-1) day(-1) dose. Cajanin increased bone mineral density (BMD) at all skeletal sites studied, bone biomechanical strength, mineral apposition rate (MAR) and bone formation rate (BFR), compared with control. BMD levels at various anatomic positions were also increased with isoformononetin compared with control however, its effect was less potent than cajanin. Isoformononetin had no effect on the parameters of bone biomechanical strength although it enhanced MAR and BFR compared with control. Isoformononetin had very mild uterotrophic effect, whereas cajanin was devoid of any such effect.
    CONCLUSIONS:
    Our data suggest that cajanin is more potent than isoformononetin in accelerating peak bone mass achievement. To the best of our knowledge, this work represents the first attempt to elucidate structure-activity relationship between the two methoxylated isoflavones regarding their effects in osteoblasts and bone formation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7,2',4'-Tetrahydroxy-8,3'-di(γ,γ-dimethylallyl)-isoflavanone; 5,7,2',4'-Tetrahydroxy-8,3'-di(gamma,gamma-dimethylallyl)-isoflavanone CFN95084 141846-47-1 C25H28O6 = 424.5 5mg QQ客服:3257982914
    2',4'-二羟基-7-甲氧基异黄酮; 5-Deoxycajanin CFN97240 7622-53-9 C16H12O5 = 284.3 5mg QQ客服:1457312923
    2',4',5,7-四羟基异黄烷酮; Dalbergioidin CFN97931 30368-42-4 C15H12O6 = 288.3 5mg QQ客服:2056216494
    2'-羟基染料木素; 2'-Hydroxygenistein CFN99257 1156-78-1 C15H10O6 = 286.2 5mg QQ客服:215959384
    Lupinalbin A; Lupinalbin A CFN80045 98094-87-2 C15H8O6 = 284.03 5mg QQ客服:2159513211
    2-羟基异樱黄素; Barpisoflavone A CFN97861 101691-27-4 C16H12O6 = 300.27 5mg QQ客服:2056216494
    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮; Cajanin CFN98419 32884-36-9 C16H12O6 = 300.3 5mg QQ客服:2056216494
    高淝任素; Homoferreirin CFN97891 482-01-9 C17H16O6 = 316.3 5mg QQ客服:1457312923
    砂生槐异黄酮 A; Sophoraisoflavone A CFN96513 117204-81-6 C20H16O6 = 352.34 5mg QQ客服:2159513211
    甘草异黄烷酮; Licoisoflavanone CFN96544 66067-26-3 C20H18O6 = 354.36 5mg QQ客服:2056216494

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产