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  • 2',4',5,7-四羟基异黄烷酮

    • 2',4',5,7-四羟基异黄烷酮

    Dalbergioidin

    2',4',5,7-四羟基异黄烷酮
    		产品编号 CFN97931
    CAS编号 30368-42-4
    分子式 = 分子量 C15H12O6 = 288.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Parochetus communis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2',4',5,7-四羟基异黄烷酮 CFN97931 30368-42-4 1mg QQ客服：3257982914
    2',4',5,7-四羟基异黄烷酮 CFN97931 30368-42-4 5mg QQ客服：3257982914
    2',4',5,7-四羟基异黄烷酮 CFN97931 30368-42-4 10mg QQ客服：3257982914
    2',4',5,7-四羟基异黄烷酮 CFN97931 30368-42-4 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Indonesia (Indonesia)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • University of South Australia (Australia)
  • University of Cincinnati (USA)
  • Kitasato University (Japan)
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  • University of Hertfordshire (United Kingdom)
  • Sri Ramachandra University (India)
  • University of Bordeaux (France)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Vienna (Austria)
  • Michigan State University (USA)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2024, 13(3):340.
  • Food Res Int.2018, 106:909-919
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Nutrients.2021, 13(3):978.
  • Processes 2021, 9(5),894.
  • Molecules.2020, 25(23):5556.
  • Int J Mol Sci.2023, 24(18):13713.
  • Anal Chim Acta.2018, 1039:162-171
  • Trop J Pharm Res.2023, 22(3):283-288.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Microchemical Journal2023, 194:109249
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Int J Mol Sci.2015, 16(8):18396-411
  • Front Immunol.2017, 8:1542
  • J Mol Med (Berl).2018, 96(7):661-672
  • JMSACL2023, 09.002
  • Nutraceuticals2022, 2(3),150-161
  • Molecules.2021, 26(6):1738.
  • Analytical Letters.2020, doi 10.1008
  • Biomedicines.2024, 12(3):495.
  • RSC Adv.2018, 32621-32636
  • Front Pharmacol.2021, 12:615157.
  • ...
    • 生物活性
    Description: Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway.
    Targets: Tyrosinase | TGF-β/Smad | ROS | PI3K | Akt | SMAD1
    In vitro:
    J Enzyme Inhib Med Chem. 2016;31(sup1):16-22.
    Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics.[Pubmed: 27558014 ]
    Campylotropis hirtella is used as a food supplement in the subtropical region of China.
    METHODS AND RESULTS:
    In an intensive hunt for human neutrophil elastase inhibitors, we isolated eight flavonoids from C. hirtella three of which (1-3) emerged to be elastase inhibitors. Geranylated flavonoids (1-3) displayed significant inhibitory activity with IC50s between 8.5 and 30.8 μM. The most striking example was geranylated isofavanone 3 that inhibited elastase significantly (IC50 = 30.8 μM) but its parent compound (Dalbergioidin) and isoflavone analog (5) were inactive (IC50 > 200 μM). Compounds (1-3) displayed different kinetic mechanisms (noncompetitive, competitive, and mixed type, respectively) that were dependent upon the parent skeleton.
    CONCLUSIONS:
    The competitive inhibitor, isoflavan-3-ol-4-one 2 manifested an inhibition of isomerization profile for elastase with kinetic parameters K5 = 0.0386 M-1S-1, K6 = 0.0244 μM-1S-1 and Kiapp = 16.3427 μM. The specific identification of metabolites was accomplished by LC-DAD-ESI/MS that was also used to analyze abundance of active components (1-3) within the plant.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草异黄烷酮; Licoisoflavanone CFN96544 66067-26-3 C20H18O6 = 354.36 5mg QQ客服：3257982914
    粗毛甘草素F; Glyasperin F CFN94013 145382-61-2 C20H18O6 = 354.35 5mg QQ客服：2159513211
    二氢甘草异黄酮; Dihydrolicoisoflavone CFN95073 164163-92-2 C20H20O6 = 356.4 5mg QQ客服：215959384
    5,7,2',4'-Tetrahydroxy-8,3'-di(γ,γ-dimethylallyl)-isoflavanone; 5,7,2',4'-Tetrahydroxy-8,3'-di(gamma,gamma-dimethylallyl)-isoflavanone CFN95084 141846-47-1 C25H28O6 = 424.5 5mg QQ客服：215959384
    2',4'-二羟基-7-甲氧基异黄酮; 5-Deoxycajanin CFN97240 7622-53-9 C16H12O5 = 284.3 5mg QQ客服：3257982914
    2',4',5,7-四羟基异黄烷酮; Dalbergioidin CFN97931 30368-42-4 C15H12O6 = 288.3 5mg QQ客服：2159513211
    2'-羟基染料木素; 2'-Hydroxygenistein CFN99257 1156-78-1 C15H10O6 = 286.2 5mg QQ客服：215959384
    Lupinalbin A; Lupinalbin A CFN80045 98094-87-2 C15H8O6 = 284.03 5mg QQ客服：2159513211
    2-羟基异樱黄素; Barpisoflavone A CFN97861 101691-27-4 C16H12O6 = 300.27 5mg QQ客服：215959384
    木豆异黄酮； 2',4',5-三羟基-7-甲氧基异黄酮; Cajanin CFN98419 32884-36-9 C16H12O6 = 300.3 5mg QQ客服：3257982914

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