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  • 白桦脂酸

    Betulinic acid

    白桦脂酸
    产品编号 CFN98706
    CAS编号 472-15-1
    分子式 = 分子量 C30H48O3 = 456.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Ziziphus jujuba.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    白桦脂酸 CFN98706 472-15-1 10mg QQ客服:215959384
    白桦脂酸 CFN98706 472-15-1 20mg QQ客服:215959384
    白桦脂酸 CFN98706 472-15-1 50mg QQ客服:215959384
    白桦脂酸 CFN98706 472-15-1 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Zurich (Switzerland)
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  • Auburn University (USA)
  • Florida A&M University (USA)
  • Institute of Chinese Materia Medica (China)
  • Vin?a Institute of Nuclear Sciences (Serbia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • RSC Adv.2023, 13(9):6317-6326.
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Front Chem.2023, 11:1245071.
  • Journal of Chromatography A2020, 460942
  • Appl. Sci. 2021, 11(22),10569
  • Environ Toxicol.2023, tox.23999.
  • Nutrients2023, 15(18), 4016.
  • Journal of Functional Foods2019, 52:430-441
  • Food Control2022, 132:108434.
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Korean J Environ Agric.2018, 37(4):260-267
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Nat Prod Sci.2016, 22(2)
  • J Pharm Biomed Anal.2021, 196:113931.
  • Foods. 2022, 11(23):3905.
  • Anticancer Res.2018, 38(4):2127-2135
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Planta Med.2016, 82(13):1208-16
  • J Mol Histol.2019, 50(4):343-354
  • Molecules.2023, 28(7):3039.
  • Oncotarget.2017, 8(64):108006-108019
  • ...
  • 生物活性
    Description: Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, immunomodulatory, anti-inflammatory and anti-tumor properties.Betulinic acid is a selective inducer of apoptosis in tumor cells, it inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression induced by carcinogens and inflammatory stimuli.
    Targets: HBV | HIV | MMP(e.g.TIMP) | TNF-α | MEK | ERK | PI3K | Akt | NF-kB | IL Receptor | COX | p65
    In vitro:
    Toxicol Appl Pharmacol. 2014 Mar 1;275(2):152-62.
    Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment.[Pubmed: 24463094]
    The present study provides evidence on the protective and therapeutic potential of Betulinic acid on cancer-associated bone diseases. Betulinic acid is a naturally occurring triterpenoid with the beneficial activity to limit the progression and severity of cancer, diabetes, cardiovascular diseases, atherosclerosis, and obesity.
    METHODS AND RESULTS:
    We first investigated its effect on breast cancer cells, osteoblastic cells, and osteoclasts in the vicious cycle of osteolytic bone metastasis. Betulinic acid reduced cell viability and the production of parathyroid hormone-related protein (PTHrP), a major osteolytic factor, in MDA-MB-231 human metastatic breast cancer cells stimulated with or without tumor growth factor-β. Betulinic acid blocked an increase in the receptor activator of nuclear factor-kappa B ligand (RANKL)/osteoprotegerin ratio by downregulating RANKL protein expression in PTHrP-treated human osteoblastic cells. In addition, Betulinic acid inhibited RANKL-induced osteoclastogenesis in murine bone marrow macrophages and decreased the production of resorbed area in plates with a bone biomimetic synthetic surface by suppressing the secretion of matrix metalloproteinase (MMP)-2, MMP-9, and cathepsin K in RANKL-induced osteoclasts. Furthermore, oral administration of Betulinic acid inhibited bone loss in mice intra-tibially inoculated with breast cancer cells and in ovariectomized mice causing estrogen deprivation, as supported by the restored bone morphometric parameters and serum bone turnover markers.
    CONCLUSIONS:
    Taken together, these findings suggest that Betulinic acid may have the potential to prevent bone loss in patients with bone metastases and cancer treatment-induced estrogen deficiency.
    Appl Microbiol Biotechnol. 2014 Apr;98(7):3081-9.
    Increase of betulinic acid production in Saccharomyces cerevisiae by balancing fatty acids and betulinic acid forming pathways.[Pubmed: 24389702]
    Betulinic acid is a plant-based triterpenoid that has been recognized for its antitumor and anti-HIV activities. The level of betulinic acid in its natural hosts is extremely low.
    METHODS AND RESULTS:
    In the present study, we constructed betulinic acid biosynthetic pathway in Saccharomyces cerevisiae by metabolic engineering. Given the betulinic acid forming pathways sharing the common substrate acetyl-CoA with fatty acid synthesis, the metabolic fluxes between the two pathways were varied by changing gene expressions, and their effects on betulinic acid production were investigated. We constructed nine S. cerevisiae strains representing nine combinations of the flux distributions between betulinic acid and fatty acid pathways. Our results demonstrated that it was possible to improve the betulinic acid production in S. cerevisiae while keeping a desirable growth phenotype by optimally balancing the carbon fluxes of the two pathways. Through modulating the expressions of the key genes on betulinic acid and fatty acid pathways, the difference in betulinic acid yield varied largely in the range of 0.01-1.92 mg L(-1) OD(-1).
    CONCLUSIONS:
    The metabolic engineering approach used in this study could be extended for synthesizing other triterpenoids in S. cerevisiae.
    Ultrastruct Pathol . Jan-Feb 2018;42(1):49-54.
    Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells[Pubmed: 29192840]
    Abstract The aim of this study is to investigate the effects of betulinic acid (BA) on triple-negative breast cancer MDA-MB-231 cells and observe the ultrastructural changes. The concentration of BA required to induce apoptosis in MDA-MB-231 cells has been previously reported. In this study, a cell counting kit-8 proliferation assay was used to measure cell viability and the apoptosis rate. Western blotting was performed to observe the protein expression levels of Bcl-2. Cell morphology and changes in cell density were observed by microscopy. Electron microscopy revealed pyknotic nuclei as well as vacuoles. Collectively, our results showed the morphological mechanisms by which BA impairs the ultrastructure of MDA-MB-231 cells.
    In vivo:
    Naunyn Schmiedebergs Arch Pharmacol . 2018 Mar;391(3):285-297.
    Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice[Pubmed: 29279966]
    Abstract Betulinic acid (BA) exhibits many biological effects including anti-inflammatory and anti-oxidant activities. Free radicals and pro-inflammatory mediators play an important role in the pathology of inflammatory bowel disease (IBD) and associated pain. We, therefore, examined the anti-oxidant, anti-inflammatory, and anti-nociceptive potential of BA in colitis. Colitis was induced with 3% (w/v) dextran sulfate sodium (DSS) in drinking water in mice for 1to7 days. BA (3, 10 and 30 mg/kg) was given orally for 0 to 7 days. BA was also tested for its efficacy in acetic acid and mustard oil-induced visceral nociception in mice at same doses. BA significantly prevented diarrhea; bleeding and colonic pathological changes induced by DSS. Further, BA reduced the colon nitrite, malondialdehyde, myeloperoxidase, and lipid hydroperoxide levels and restored the superoxide dismutase, catalase and reduced glutathione levels to normalize the redox balance in DSS-exposed mice. Inflammatory mediators like matrix metalloproteinase-9 and prostaglandin E2 levels were also significantly attenuated by BA in colitis mice. Additionally, BA reduced acetic acid and mustard oil-induced visceral pain in mice. In conclusion, the results of the present study suggest that BA possesses good anti-nociceptive activity and the anti-IBD effects of BA are due to its anti-oxidant and anti-inflammatory potential.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1896 mL 10.9481 mL 21.8962 mL 43.7924 mL 54.7405 mL
    5 mM 0.4379 mL 2.1896 mL 4.3792 mL 8.7585 mL 10.9481 mL
    10 mM 0.219 mL 1.0948 mL 2.1896 mL 4.3792 mL 5.4741 mL
    50 mM 0.0438 mL 0.219 mL 0.4379 mL 0.8758 mL 1.0948 mL
    100 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4379 mL 0.5474 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苦苏花皂苷C; Cussosaponin C CFN90772 366814-42-8 C59H96O25 = 1204 5mg QQ客服:1457312923
    路路通酸; Betulonic acid CFN98682 4481-62-3 C30H46O3 = 454.7 20mg QQ客服:2159513211
    20-Hydroxy-3-oxo-28-lupanoic acid; 20-Hydroxy-3-oxo-28-lupanoic acid CFN97504 93372-87-3 C30H48O4 = 472.7 5mg QQ客服:3257982914
    麦珠子酸; Alphitolic acid CFN99896 19533-92-7 C30H48O4 = 472.7 5mg QQ客服:2159513211
    2alpha-羟基-3beta-乙酰白桦酸; 2alpha-hydroxy-3beta-acetyloxy-betulic acid CFN92092 1163728-89-9 C32H50O5 = 514.8 5mg QQ客服:1457312923
    3,27-二羟基-20(29)-流明-28-酸甲酯; 3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester CFN98305 263844-79-7 C31H50O4 = 486.7 5mg QQ客服:1457312923
    3-乙酰氧基-27-羟基-20(29)-流明-28-羧酸甲酯; 3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester CFN98306 263844-80-0 C33H52O5 = 528.8 5mg QQ客服:215959384
    23-羟基白桦酸; Anemosapogenin CFN90310 85999-40-2 C30H48O4 = 472.71 20mg QQ客服:2159513211
    白头翁皂苷A3; Anemoside A3 CFN90182 129724-84-1 C41H66O12 = 750.96 20mg QQ客服:1457312923
    白头翁皂苷D; Pulsatilla saponin D CFN80453 848784-85-0 C47H76O17 = 913.10 5mg QQ客服:215959384

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