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  • 山药素 III

    Batatasin III

    山药素 III
    产品编号 CFN92689
    CAS编号 56684-87-8
    分子式 = 分子量 C15H16O3 = 244.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Dendrobium venustum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    山药素 III CFN92689 56684-87-8 1mg QQ客服:215959384
    山药素 III CFN92689 56684-87-8 5mg QQ客服:215959384
    山药素 III CFN92689 56684-87-8 10mg QQ客服:215959384
    山药素 III CFN92689 56684-87-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Northeast Normal University Changchun (China)
  • University of Hull (United Kingdom)
  • Pennsylvania State University (USA)
  • University of the Basque Country (Spain)
  • University of Helsinki (Finland)
  • FORTH-IMBB (Greece)
  • Rio de Janeiro State University (Brazil)
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  • Medizinische Universit?t Wien (Austria)
  • University of Illinois (USA)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2020, 332:127412
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • J Ethnopharmacol.2019, 235:406-414
  • Tea Res. Ins. Of China2017, 1-12
  • Appl. Sci.2020, 10(16),5482.
  • Environ Toxicol.2020, doi: 10.1002
  • Life (Basel).2021, 11(7):616.
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • Korean J Pain.2021, 34(4):405-416.
  • Molecules.2019, 24(7):E1290
  • Toxicol In Vitro.2019, 59:161-178
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Fitoterapia.2022, 157:105130.
  • Nutrients.2022, 14(16):3393.
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Int J Mol Sci.2022, 23(23):15213.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Biosci. Rep.2020, 10.1024
  • JEJU National University2022, 10478.
  • Korean J Dent Mater2020, 47(2):63-70.
  • Food Chem.2019, 276:768-775
  • ...
  • 生物活性
    Description: Batatasin III may have a long-term inhibitory effect on whole plant growth, shows germination inhibitory activity. Batatasin III may impose a lethal effect on the aquatic fauna in small streams.
    In vitro:
    J Chem Ecol. 2004 Jan;30(1):215-27.
    Potential toxic effect on aquatic fauna by the dwarf shrub Empetrum hermaphroditum.[Pubmed: 15074667]
    The common evergreen dwarf shrub Empetrum hermaphroditum has influence on the functioning of boreal terrestrial ecosystems in northern Sweden. The negative effects of E. hermaphroditum are partly attributed to the production of the dihydrostilbene, batatasin III, which is released from leaves and litter by rain and snowmelt.
    METHODS AND RESULTS:
    In this study, we investigated whether Batatasin III is carried by runoff into streams and lakes during the snowmelt period and whether it is also potentially hazardous to aquatic fauna. The maximum concentration of Batatasin III found was 1.06 mg l(-1). The proportion of dead yolk sac alevins increased significantly (P < 0.001) with increasing concentrations of Batatasin III and time of exposure. After 24 hr, EC50 was 10 mg l(-1). It was 2 mg l(-1) after 48 hr. The effect of phenol was negligible, indicating a specific phytotoxic effect of the bibenzyl structure of Batatasin III. The proportion of mobile D. magna became significantly smaller (P < 0.001) with increasing concentrations of Batatasin III, with decreasing pH, and with increasing exposure time. EC50 varied between 7 and 17 mg l(-1) at pH 5.5 and 7.0, respectively. After 24 hr EC50 decreased and was 2.5 at pH 5.5 and 12 mg l(-1) at pH 7.0. The levels of Batatasin III found in the field samples were below the lowest EC50 in acute toxicity tests.
    CONCLUSIONS:
    However, in view of the interactive effect of pH and exposure time, this study suggests that this stable plant metabolite may impose a lethal effect on the aquatic fauna in small streams.
    Physiol Plant. 2001 Nov;113(3):368-376.
    The inhibition of ammonium uptake in excised birch (Betula pendula) roots by batatasin-III.[Pubmed: 12060282]
    We investigated whether Batatasin III has the potential to interfere with NH4+ uptake in birch (Betula pendula) roots.
    METHODS AND RESULTS:
    Excised birch roots were exposed to Batatasin III during brief periods in 15NH4+ solutions, and then analyzed for labeled N. Batatasin III inhibited N-NH4+ uptake by 28, 89 and 95% compared with the control, when roots were treated with 0.1, 1.0 and 2.8 mM of Batatasin III, respectively. The effect of 1.0-mM Batatasin III was greater at pH 4.2 than at pH 6.8. In addition, the inhibition of N-NH4+ uptake by Batatasin III was not reversed after rinsing the roots in water and transferring them to a Batatasin III free solution. Furthermore, birch seedlings immersed in a 1.0-mM Batatasin III solution for 2 h, and then replanted in pots with soil, had decreased growth, such that 10 weeks after treatment, the dry mass of both shoots and roots was reduced by 74 and 73%, respectively, compared with control seedlings. This suggests that a brief exposure to Batatasin III may have a long-term inhibitory effect on whole plant growth. Using plasma membrane vesicles isolated from easily extractable spinach (Spinacia oleracea) leaves, it was found that Batatasin III strongly inhibited proton pumping in isolated plasma membrane vesicles, while it only slightly inhibited ATP hydrolytic activity. The uncoupling of proton pumping from ATP hydrolytic activity suggests that Batatasin III disturbs membrane integrity.
    CONCLUSIONS:
    This hypothesis was further supported by a greater efflux of ions from birch roots immersed in a Batatasin III solution than from roots in a control solution.
    Anticancer Res . 2017 Nov;37(11):6281-6289.
    Batatasin III Inhibits Migration of Human Lung Cancer Cells by Suppressing Epithelial to Mesenchymal Transition and FAK-AKT Signals[Pubmed: 29061811]
    Abstract Background/aim: Lung cancer is the leading cause of cancer-related deaths worldwide. Compound Batatasin III isolated from Dendrobium draconis Rchb.f. was tested for the possible anti-cancer activities including anti-proliferative, anti-migration and invasion in human non-small lung cancer H460 cells. Materials and methods: The effect of Batatasin III on viability and proliferation of H460 cells was investigated by the 3-[4,5-dimethylthiazol-2-yl]-2,5diphenyl tetrazoliumbromide (MTT) assay. Migration and invasion assays were performed. Filopodia formation was determined by phalloidin-rhodamine staining. The hallmark signaling proteins in regulation of epithelial to mesenchymal transition (EMT), proliferation, and migration were determined by western blot analysis. Results: Batatasin III at concentrations lower than 100 μM has no cytotoxic effects. The compound at 25-100 μM exhibited anti-proliferative activity at 48 h after treatment. Regarding cell motility, Batatasin III decreased migration and invasion of cells. Filopodia were found to be significantly reduced in Batatasin III treated cells. These effects correlated with the results from western blot analysis showing that the phosphorylation of focal adhesion kinase on Try397 (p-FAK (Try397)), the active protein kinase B (AKT), and cell division cycle 42 (CDC42) were significantly reduced. Besides, Batatasin III significantly suppressed EMT indicated by the decrease of N-cadherin and Vimentin, and up-regulation of E-cadherin. Conclusion: Batatasin III has anti-cancer activities; inhibits cancer migration and invasion by suppressing EMT. Our findings establish Batatasin III as a potential compound for further studies aimed at finding a better, more effective treatment approach for lung cancer. Keywords: AKT; Batatasin III; FAK; epithelial to mesenchymal transition; invasion; lung cancer; migration.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0933 mL 20.4666 mL 40.9333 mL 81.8666 mL 102.3332 mL
    5 mM 0.8187 mL 4.0933 mL 8.1867 mL 16.3733 mL 20.4666 mL
    10 mM 0.4093 mL 2.0467 mL 4.0933 mL 8.1867 mL 10.2333 mL
    50 mM 0.0819 mL 0.4093 mL 0.8187 mL 1.6373 mL 2.0467 mL
    100 mM 0.0409 mL 0.2047 mL 0.4093 mL 0.8187 mL 1.0233 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Thunalbene; Thunalbene CFN92783 220862-05-5 C15H14O3 = 242.3 5mg QQ客服:2056216494
    3'-O-甲基山药素III; 3'-O-Methylbatatasin III CFN91176 101330-69-2 C16H18O3 = 258.3 10mg QQ客服:215959384
    山药素 III; Batatasin III CFN92689 56684-87-8 C15H16O3 = 244.3 5mg QQ客服:1457312923
    山药素 IV; Batatasin IV CFN95319 60347-67-3 C15H16O3 = 244.3 5mg QQ客服:2159513211
    3-甲氧基-5-[2-(2-甲氧基苯基)乙基]苯酚; Stilbostemin N CFN97863 1000676-45-8 C16H18O3 = 258.32 5mg QQ客服:1457312923
    山药素 V; Batatasin V CFN95320 65817-45-0 C17H20O4 = 288.3 5mg QQ客服:1413575084
    紫檀芪; Pterostilbene CFN90397 537-42-8 C16H16O3 = 256.30 20mg QQ客服:3257982914
    3-羟基-4',5-二甲氧基二苯乙烯; 3-Hydroxy-4',5-dimethoxystilbene CFN95199 58436-29-6 C16H16O3 = 256.3 10mg QQ客服:1413575084
    白藜芦醇三甲醚; Trimethoxystilbene CFN90874 22255-22-7 C17H18O3 = 270.3 20mg QQ客服:1457312923
    3,5-二甲氧基-3'-羟基联苄; 3,5-Dimethoxy-3'-hydroxybibenzyl CFN89540 168281-05-8 C16H18O3 = 258.31 5mg QQ客服:215959384

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