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  • 黄卡瓦胡椒素C

    Flavokawain C

    黄卡瓦胡椒素C
    产品编号 CFN90741
    CAS编号 56798-34-6
    分子式 = 分子量 C17H16O5 = 300.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The roots of Piper methysticum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄卡瓦胡椒素C CFN90741 56798-34-6 1mg QQ客服:1457312923
    黄卡瓦胡椒素C CFN90741 56798-34-6 5mg QQ客服:1457312923
    黄卡瓦胡椒素C CFN90741 56798-34-6 10mg QQ客服:1457312923
    黄卡瓦胡椒素C CFN90741 56798-34-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Deutsches Krebsforschungszentrum (Germany)
  • National Cancer Institute (USA)
  • University of Toronto (Canada)
  • Istanbul University (Turkey)
  • Kyushu University (Japan)
  • Pennsylvania State University (USA)
  • Amity University (India)
  • Indian Institute of Science (India)
  • University of Ioannina (Greece)
  • Cornell University (USA)
  • University of Helsinki (Finland)
  • University of Madras (India)
  • Kazusa DNA Research Institute (Japan)
  • Lund University (Sweden)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(11)
  • Molecules.2019, 25(1):E103
  • Metabolites.2019, 9(11):E271
  • BioRxiv-The Preprint server for biology2023, 586957.
  • Foods.2021, 10(12):2929.
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Pharmacol Rep.2022, 74(1):175-188.
  • Nutrients.2023, 15(12):2644.
  • Food Chem.2019, 275:746-753
  • University of Stuttgart2021, 11682.
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • Int J Mol Sci.2019, 20(8):E1855
  • Int J Mol Sci.2024, 25(2):764.
  • Journal of Functional Foods2022, 96: 105216.
  • Molecules.2017, 22(2)
  • Rep.Grant.Res.,Asahi Glass Foun.2023, No.119.
  • J Ethnopharmacol.2020, 249:112396
  • Processes2022, 10(10), 2008.
  • Molecules2022, 27(9):2827.
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • Phytomedicine.2022, 100:154036.
  • Acta Chromatographica2021, 00960.
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • ...
  • 生物活性
    Description: Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 uM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.
    Targets: NADPH-oxidase | AChR | MAPK | Akt
    In vitro:
    Cancer Cell International 2013, 13:102
    The flavokawains: uprising medicinal chalcones[Reference: WebLink]
    Plant-based compounds have been in the spotlight in search of new and promising drugs.
    METHODS AND RESULTS:
    Flavokawain A, Flavokawain B and Flavokawain C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and Flavokawain B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and Flavokawain C. Flavokawain B also exerts antinociceptive effects as well as antiinflammation properties.
    CONCLUSIONS:
    This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported
    Bioorg Med Chem Lett. 2015 Feb 15;25(4):799-802.
    Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.[Pubmed: 25597012]
    The ethanolic extract of the root of Piper methysticum was found to inhibit melanogenesis in MSH-activated B16 melanoma cells.
    METHODS AND RESULTS:
    Flavokawain B and Flavokawain C were isolated from this extract based on their anti-melanogenesis activity and found to inhibit melanogenesis with IC50 values of 7.7μM and 6.9μM, respectively. Flavokawain analogs were synthesized through a Claisen-Schmidt condensation of their corresponding acetophenones and benzaldehydes and were evaluated in terms of their tyrosinase inhibitory and anti-melanogenesis activities.
    CONCLUSIONS:
    Compound 1b was the most potent of these with an IC50 value of 2.3μM in melanogenesis inhibition assays using MSH-activated B16 melanoma cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2',4'-二羟基-4,6'-二甲氧基二氢查尔酮; 2,4-Dihydroxy-4,6-dimethoxydihydrochalcone CFN97962 75679-58-2 C17H18O5 = 302.3 5mg QQ客服:3257982914
    2',6'-二羟基-4,4'-二甲氧基查耳酮; 2',6'-Dihydroxy-4,4'-dimethoxychalcone CFN70304 20621-49-2 C17H16O5 = 300.3 5mg QQ客服:1413575084
    2',4'-二羟基-4,6'-二甲氧基查耳酮; 4-O-Methylhelichrysetin CFN96080 56121-44-9 C17H16O5 = 300.3 5mg QQ客服:1413575084
    4,4'-二羟基-2',6'-二甲氧基查耳酮 ; 2'-O-Methylhelichrysetin CFN97920 123316-64-3 C17H16O5 = 300.3 5mg QQ客服:2159513211
    黄卡瓦胡椒素C; Flavokawain C CFN90741 56798-34-6 C17H16O5 = 300.3 10mg QQ客服:215959384
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮; Flavokawain A CFN98446 3420-72-2 C18H18O5 = 314.3 10mg QQ客服:215959384
    2',4',6',4-四甲氧基查耳酮; 2',4',6',4-Tetramethoxychalcone CFN91683 94103-36-3 C19H20O5 = 328.4 5mg QQ客服:1457312923
    2',4'-二羟基-2,3',6'- 三甲氧基查尔酮; 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone CFN99015 100079-39-8 C18H18O6 = 330.3 5mg QQ客服:215959384
    3'-Methylflavokawin; 3'-Methylflavokawin CFN96084 1044743-35-2 C18H18O5 = 314.3 5mg QQ客服:2056216494
    3'-甲基-2',4'-二羟基-4,6'-二甲氧基查耳酮 ; 3'-Methyl-4-O-methylhelichrysetin CFN96164 109471-13-8 C18H18O5 = 314.3 5mg QQ客服:215959384

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