黄卡瓦胡椒素C

Flavokawain C

	产品编号	CFN90741
	CAS编号	56798-34-6
	分子式 = 分子量	C₁₇H₁₆O₅ = 300.3
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Chalcones
	植物来源	The roots of Piper methysticum.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
黄卡瓦胡椒素C	CFN90741	56798-34-6	1mg	QQ客服：215959384
黄卡瓦胡椒素C	CFN90741	56798-34-6	5mg	QQ客服：215959384
黄卡瓦胡椒素C	CFN90741	56798-34-6	10mg	QQ客服：215959384
黄卡瓦胡椒素C	CFN90741	56798-34-6	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Nanjing University of Chinese Medicine (China)

Chang Gung University (Taiwan)

National Chung Hsing University (Taiwan)

Univerzita Karlova v Praze (Czech Republic)

University of Cincinnati (USA)

John Innes Centre (United Kingdom)

The Institute of Cancer Research (United Kingdom)

VIT University (India)

Istanbul University (Turkey)

Uniwersytet Gdański (Poland)

Wageningen University (Netherlands)

Universitas islam negeri Jakarta (Indonesia)

Universidad Industrial de Santander (Colombia)

Siksha O Anusandhan University (India)

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Description:

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 uM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

Targets:

NADPH-oxidase | AChR | MAPK | Akt

In vitro:

Cancer Cell International 2013, 13:102

The flavokawains: uprising medicinal chalcones[Reference: WebLink]

Plant-based compounds have been in the spotlight in search of new and promising drugs.
METHODS AND RESULTS:
Flavokawain A, Flavokawain B and Flavokawain C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and Flavokawain B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and Flavokawain C. Flavokawain B also exerts antinociceptive effects as well as antiinflammation properties.
CONCLUSIONS:
This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported

Bioorg Med Chem Lett. 2015 Feb 15;25(4):799-802.

Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.[Pubmed: 25597012]

The ethanolic extract of the root of Piper methysticum was found to inhibit melanogenesis in MSH-activated B16 melanoma cells.
METHODS AND RESULTS:
Flavokawain B and Flavokawain C were isolated from this extract based on their anti-melanogenesis activity and found to inhibit melanogenesis with IC50 values of 7.7μM and 6.9μM, respectively. Flavokawain analogs were synthesized through a Claisen-Schmidt condensation of their corresponding acetophenones and benzaldehydes and were evaluated in terms of their tyrosinase inhibitory and anti-melanogenesis activities.
CONCLUSIONS:
Compound 1b was the most potent of these with an IC50 value of 2.3μM in melanogenesis inhibition assays using MSH-activated B16 melanoma cells.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异甘草素； 4,2',4'-三羟基查耳酮; Isoliquiritigenin	CFN97542	961-29-5	C₁₅H₁₂O₄ = 256.3	20mg	QQ客服：215959384
2''-O-甲基异甘草苷元; 4,4'-二羟基-2'-甲氧基查耳酮; 2'-O-Methylisoliquiritigenin	CFN98832	51828-10-5	C₁₆H₁₄O₄ = 270.3	5mg	QQ客服：3257982914
3-去氧苏木查耳酮; 3-Deoxysappanchalcone	CFN92833	112408-67-0	C₁₆H₁₄O₄ = 270.3	5mg	QQ客服：3257982914
4,2'-Dihydroxy-4'-methoxychalcone ; 4,2'-Dihydroxy-4'-methoxychalcone	CFN89427	63529-06-6	C₁₆H₁₄O₄ = 270.28	5mg	QQ客服：1457312923
根皮素; Phloretin	CFN97040	60-82-2	C₁₅H₁₄O₅ = 274.3	20mg	QQ客服：2159513211
4'-O-甲基根皮素 ; Asebogenin	CFN96928	520-42-3	C₁₆H₁₆O₅ = 288.29	5mg	QQ客服：2056216494
2',6'-二羟基-4,4'-二甲氧基二氢查耳酮; 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone	CFN70345	35241-54-4	C₁₇H₁₈O₅ = 302.3	5mg	QQ客服：2056216494
2-甲氧基根皮素; 2'-O-Methylphloretin (4,2',4'-Trihydroxy-6'-methoxydihydrochalcone)	CFN91680	111316-17-7	C₁₆H₁₆O₅ = 288.3	5mg	QQ客服：3257982914
4,2',4'-三羟基-6'-甲氧基查耳酮; Helichrysetin	CFN97065	62014-87-3	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：1413575084
2',4'-二羟基-4,6'-二甲氧基二氢查尔酮; 2,4-Dihydroxy-4,6-dimethoxydihydrochalcone	CFN97962	75679-58-2	C₁₇H₁₈O₅ = 302.3	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.33 mL	16.65 mL	33.3 mL	66.6001 mL	83.2501 mL
5 mM	0.666 mL	3.33 mL	6.66 mL	13.32 mL	16.65 mL
10 mM	0.333 mL	1.665 mL	3.33 mL	6.66 mL	8.325 mL
50 mM	0.0666 mL	0.333 mL	0.666 mL	1.332 mL	1.665 mL
100 mM	0.0333 mL	0.1665 mL	0.333 mL	0.666 mL	0.8325 mL