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  • 黄卡瓦胡椒素C

    Flavokawain C

    黄卡瓦胡椒素C
    产品编号 CFN90741
    CAS编号 56798-34-6
    分子式 = 分子量 C17H16O5 = 300.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The roots of Piper methysticum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄卡瓦胡椒素C CFN90741 56798-34-6 1mg QQ客服:215959384
    黄卡瓦胡椒素C CFN90741 56798-34-6 5mg QQ客服:215959384
    黄卡瓦胡椒素C CFN90741 56798-34-6 10mg QQ客服:215959384
    黄卡瓦胡椒素C CFN90741 56798-34-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Malaysia Pahang (Malaysia)
  • University of Perugia (Italy)
  • University of Queensland (Australia)
  • Shanghai University of TCM (China)
  • University of Brasilia (Brazil)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • University of Bonn (Germany)
  • Semmelweis Unicersity (Hungary)
  • Mahidol University (Thailand)
  • Korea Food Research Institute(KFRI) (Korea)
  • Universidad Veracuzana (Mexico)
  • Monash University Malaysia (Malaysia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Weizmann Institute of Science (Israel)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Food Biochem.2021, 45(7):e13774.
  • Int J Biol Macromol.2020, 169:342-351
  • Molecules.2019, 24(24),4583
  • J Ethnopharmacol.2022, 289:115018.
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Bioorg Med Chem.2020, 28(12):115553.
  • Int J Mol Sci.2021, 22(9):5012.
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • Preprints2022, 202211.0388.v1.
  • Anticancer Res.2018, 38(4):2127-2135
  • Vietnam J. Chem.2023, 61(3),308-317
  • LWT2021, 147:111620.
  • J Ethnopharmacol.2024, 318:116863.
  • Neurotox Res.2022, 40(6):1937-1947.
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Int J Mol Sci.2022, 23(21):13112.
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Environ Toxicol.2020, doi: 10.1002
  • Journal of Ginseng Research2021, 25 November
  • Journal of Analytical Chemistry2017, 854-861
  • Sci Rep. 2017, 8207(7)
  • Chemistry of Plant Materials.2016, 33-46
  • ...
  • 生物活性
    Description: Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 uM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.
    Targets: NADPH-oxidase | AChR | MAPK | Akt
    In vitro:
    Cancer Cell International 2013, 13:102
    The flavokawains: uprising medicinal chalcones[Reference: WebLink]
    Plant-based compounds have been in the spotlight in search of new and promising drugs.
    METHODS AND RESULTS:
    Flavokawain A, Flavokawain B and Flavokawain C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and Flavokawain B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and Flavokawain C. Flavokawain B also exerts antinociceptive effects as well as antiinflammation properties.
    CONCLUSIONS:
    This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported
    Bioorg Med Chem Lett. 2015 Feb 15;25(4):799-802.
    Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.[Pubmed: 25597012]
    The ethanolic extract of the root of Piper methysticum was found to inhibit melanogenesis in MSH-activated B16 melanoma cells.
    METHODS AND RESULTS:
    Flavokawain B and Flavokawain C were isolated from this extract based on their anti-melanogenesis activity and found to inhibit melanogenesis with IC50 values of 7.7μM and 6.9μM, respectively. Flavokawain analogs were synthesized through a Claisen-Schmidt condensation of their corresponding acetophenones and benzaldehydes and were evaluated in terms of their tyrosinase inhibitory and anti-melanogenesis activities.
    CONCLUSIONS:
    Compound 1b was the most potent of these with an IC50 value of 2.3μM in melanogenesis inhibition assays using MSH-activated B16 melanoma cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-Methylflavokawin; 3'-Methylflavokawin CFN96084 1044743-35-2 C18H18O5 = 314.3 5mg QQ客服:1457312923
    3'-甲基-2',4'-二羟基-4,6'-二甲氧基查耳酮 ; 3'-Methyl-4-O-methylhelichrysetin CFN96164 109471-13-8 C18H18O5 = 314.3 5mg QQ客服:3257982914
    4,4'-二甲氧基查耳酮; 4,4'-Dimethoxychalcone CFN70472 2373-89-9 C17H16O3 = 268.3 5mg QQ客服:2056216494
    异甘草素; 4,2',4'-三羟基查耳酮; Isoliquiritigenin CFN97542 961-29-5 C15H12O4 = 256.3 20mg QQ客服:3257982914
    2''-O-甲基异甘草苷元; 4,4'-二羟基-2'-甲氧基查耳酮; 2'-O-Methylisoliquiritigenin CFN98832 51828-10-5 C16H14O4 = 270.3 5mg QQ客服:2159513211
    3-去氧苏木查耳酮; 3-Deoxysappanchalcone CFN92833 112408-67-0 C16H14O4 = 270.3 5mg QQ客服:1413575084
    4,2'-Dihydroxy-4'-methoxychalcone ; 4,2'-Dihydroxy-4'-methoxychalcone CFN89427 63529-06-6 C16H14O4 = 270.28 5mg QQ客服:2159513211
    根皮素; Phloretin CFN97040 60-82-2 C15H14O5 = 274.3 20mg QQ客服:1413575084
    4'-O-甲基根皮素 ; Asebogenin CFN96928 520-42-3 C16H16O5 = 288.29 5mg QQ客服:1413575084
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮; 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone CFN70345 35241-54-4 C17H18O5 = 302.3 5mg QQ客服:215959384

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