黄卡瓦胡椒素C

Flavokawain C

	产品编号	CFN90741
	CAS编号	56798-34-6
	分子式 = 分子量	C₁₇H₁₆O₅ = 300.3
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Chalcones
	植物来源	The roots of Piper methysticum.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
黄卡瓦胡椒素C	CFN90741	56798-34-6	1mg	QQ客服：3257982914
黄卡瓦胡椒素C	CFN90741	56798-34-6	5mg	QQ客服：3257982914
黄卡瓦胡椒素C	CFN90741	56798-34-6	10mg	QQ客服：3257982914
黄卡瓦胡椒素C	CFN90741	56798-34-6	20mg	QQ客服：3257982914

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Centralised Purchases Unit (CPU), B.I.T.S (India)

University of Minnesota (USA)

University of Maryland School of Medicine (USA)

University of Wisconsin-Madison (USA)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Monash University (Australia)

Colorado State University (USA)

Kyushu University (Japan)

Universidad de La Salle (Mexico)

University of South Australia (Australia)

S.N.D.T. Women's University (India)

University of Auckland (New Zealand)

Florida International University (USA)

Indian Institute of Science (India)

More...

Description:

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 uM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

Targets:

NADPH-oxidase | AChR | MAPK | Akt

In vitro:

Cancer Cell International 2013, 13:102

The flavokawains: uprising medicinal chalcones[Reference: WebLink]

Plant-based compounds have been in the spotlight in search of new and promising drugs.
METHODS AND RESULTS:
Flavokawain A, Flavokawain B and Flavokawain C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and Flavokawain B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and Flavokawain C. Flavokawain B also exerts antinociceptive effects as well as antiinflammation properties.
CONCLUSIONS:
This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported

Bioorg Med Chem Lett. 2015 Feb 15;25(4):799-802.

Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.[Pubmed: 25597012]

The ethanolic extract of the root of Piper methysticum was found to inhibit melanogenesis in MSH-activated B16 melanoma cells.
METHODS AND RESULTS:
Flavokawain B and Flavokawain C were isolated from this extract based on their anti-melanogenesis activity and found to inhibit melanogenesis with IC50 values of 7.7μM and 6.9μM, respectively. Flavokawain analogs were synthesized through a Claisen-Schmidt condensation of their corresponding acetophenones and benzaldehydes and were evaluated in terms of their tyrosinase inhibitory and anti-melanogenesis activities.
CONCLUSIONS:
Compound 1b was the most potent of these with an IC50 value of 2.3μM in melanogenesis inhibition assays using MSH-activated B16 melanoma cells.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4,4'-二羟基-2',6'-二甲氧基查耳酮 ; 2'-O-Methylhelichrysetin	CFN97920	123316-64-3	C₁₇H₁₆O₅ = 300.3	5mg	QQ客服：1457312923
黄卡瓦胡椒素C; Flavokawain C	CFN90741	56798-34-6	C₁₇H₁₆O₅ = 300.3	10mg	QQ客服：215959384
黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮; Flavokawain A	CFN98446	3420-72-2	C₁₈H₁₈O₅ = 314.3	10mg	QQ客服：1457312923
2',4',6',4-四甲氧基查耳酮; 2',4',6',4-Tetramethoxychalcone	CFN91683	94103-36-3	C₁₉H₂₀O₅ = 328.4	5mg	QQ客服：1457312923
2',4'-二羟基-2,3',6'- 三甲氧基查尔酮; 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone	CFN99015	100079-39-8	C₁₈H₁₈O₆ = 330.3	5mg	QQ客服：2056216494
3'-Methylflavokawin; 3'-Methylflavokawin	CFN96084	1044743-35-2	C₁₈H₁₈O₅ = 314.3	5mg	QQ客服：215959384
3'-甲基-2',4'-二羟基-4,6'-二甲氧基查耳酮 ; 3'-Methyl-4-O-methylhelichrysetin	CFN96164	109471-13-8	C₁₈H₁₈O₅ = 314.3	5mg	QQ客服：1457312923
4,4'-二甲氧基查耳酮; 4,4'-Dimethoxychalcone	CFN70472	2373-89-9	C₁₇H₁₆O₃ = 268.3	5mg	QQ客服：3257982914
异甘草素； 4,2',4'-三羟基查耳酮; Isoliquiritigenin	CFN97542	961-29-5	C₁₅H₁₂O₄ = 256.3	20mg	QQ客服：215959384
2''-O-甲基异甘草苷元; 4,4'-二羟基-2'-甲氧基查耳酮; 2'-O-Methylisoliquiritigenin	CFN98832	51828-10-5	C₁₆H₁₄O₄ = 270.3	5mg	QQ客服：2056216494

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.33 mL	16.65 mL	33.3 mL	66.6001 mL	83.2501 mL
5 mM	0.666 mL	3.33 mL	6.66 mL	13.32 mL	16.65 mL
10 mM	0.333 mL	1.665 mL	3.33 mL	6.66 mL	8.325 mL
50 mM	0.0666 mL	0.333 mL	0.666 mL	1.332 mL	1.665 mL
100 mM	0.0333 mL	0.1665 mL	0.333 mL	0.666 mL	0.8325 mL