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  • 黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮

    Flavokawain A

    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮
    产品编号 CFN98446
    CAS编号 3420-72-2
    分子式 = 分子量 C18H18O5 = 314.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The roots of Piper methysticum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮 CFN98446 3420-72-2 1mg QQ客服:2056216494
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮 CFN98446 3420-72-2 5mg QQ客服:2056216494
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮 CFN98446 3420-72-2 10mg QQ客服:2056216494
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮 CFN98446 3420-72-2 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Monash University (Australia)
  • University of Amsterdam (Netherlands)
  • University of Indonesia (Indonesia)
  • University of Oslo (Norway)
  • Medical University of South Carolina (USA)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Universidad de La Salle (Mexico)
  • Sanford Burnham Medical Research Institute (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Georgia Institute of Technology (USA)
  • University of Leipzig (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Toxins (Basel).2021, 13(9):593.
  • Front. Pharmacol.2022, 901563.
  • J Med Food.2020, 23(6):633-640.
  • J Separation Science & Technology2016, 51:1579-1588
  • J Nat Med.2020, 74(1):65-75
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • Nutrients2022, 14(14)2929
  • J Cell Biochem.2022, 123(7):1222-1236.
  • Environ Toxicol.2020, doi: 10.1002
  • Curr Issues Mol Biol.2023, 45(3):2136-2156.
  • Int J Mol Sci.2023, 24(5):4505.
  • J.Food Processing & Preservation2022, jfpp.16666
  • Nat Prod Sci.2014, 20(3):182-190
  • Mol Med Rep.2024, 29(2):26.
  • Food Chem.2023, 404(Pt A):134517.
  • Korean J Dent Mater.2018, 45(2):139-146
  • Front Plant Sci.2021, 12: 648426.
  • Mol Med Rep.2022, 26(4):299.
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Appl. Sci.2020, 10(8),2804
  • J Nat Prod.2018, 81(4):966-975
  • Metabolites2023, 13(1), 3.
  • Molecules.2022, 27(7):2093.
  • ...
  • 生物活性
    Description: Flavokawain A is an apoptotic inducer and immune- modulator ,it also shows anti-inflammatory, and anti-tumor activities.Flavokawain A can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.Flavokawain A may suppress LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.
    Targets: NF-kB | AP-1 | JNK | p38MAPK | TNF-α | CDK | NOS | COX | NO | PGE | IL Receptor | p53 | p21
    In vitro:
    Food Chem Toxicol. 2013 Aug;58:479-86.
    Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages.[Pubmed: 23727179 ]
    Flavokawain A, a major constituent of chalcones derived from kava extracts, exerts various biological activities such as anti-tumor activities.
    METHODS AND RESULTS:
    In this study, we examined the suppressive effect of flavokawain A on LPS-induced expression of pro-inflammatory mediators and the molecular mechanisms responsible for these activities in the murine macrophages. Flavokawain A significantly suppressed expression of iNOS and COX-2, as well as the subsequent production of NO and PGE2 in the LPS-stimulated RAW 264.7 cells. Flavokawain A significantly inhibited LPS-induced activation of NF-κB and AP-1 signaling pathways. In addition, flavokawain A inhibited activation of JNK and p38 MAPK which was responsible for expression of iNOS and COX-2 in the LPS-stimulated RAW 264.7 cells. Furthermore, flavokawain A suppressed LPS-induced expression of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6.
    CONCLUSIONS:
    These results suggest that flavokawain A may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.
    PLoS One. 2014 Oct 6;9(10):e105244.
    Flavokawain A induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro.[Pubmed: 25286005]
    The kava-kava plant (Piper methsyticum) is traditionally known as the pacific elixir by the pacific islanders for its role in a wide range of biological activities. The extract of the roots of this plant contains a variety of interesting molecules including Flavokawain A and this molecule is known to have anti-cancer properties. Breast cancer is still one of the leading diagnosed cancers in women today. The metastatic process is also very pertinent in the progression of tumorigenesis.
    METHODS AND RESULTS:
    MCF-7 and MDA-MB231 cells were treated with several concentrations of FKA. The apoptotic analysis was done through the MTT assay, BrdU assay, Annexin V analysis, cell cycle analysis, JC-1 mitochondrial dye, AO/PI dual staining, caspase 8/9 fluorometric assay, quantitative real time PCR and western blot. For the metastatic assays, the in vitro scratch assay, trans-well migration/invasion assay, HUVEC tube formation assay, ex vivo rat aortic ring assay, quantitative real time PCR and western blot were employed. We have investigated the effects of FKA on the apoptotic and metastatic process in two breast cancer cell lines. FKA induces apoptosis in both MCF-7 and MDA-MB231 in a dose dependent manner through the intrinsic mitochondrial pathway. Additionally, FKA selectively induces a G2/M arrest in the cell cycle machinery of MDA-MB231 and G1 arrest in MCF-7. This suggests that FKA's anti-cancer activity is dependent on the p53 status. Moreover, FKA also halted the migration and invasion process in MDA-MB231. The similar effects can be seen in the inhibition of the angiogenesis process as well.
    CONCLUSIONS:
    FKA managed to induce apoptosis and inhibit the metastatic process in two breast cancer cell lines, in vitro. Overall, FKA may serve as a promising candidate in the search of a new anti-cancer drug especially in halting the metastatic process but further in vivo evidence is needed.
    Cancer Res. 2005 Apr 15;65(8):3479-86.
    Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.[Pubmed: 15833884]
    Consumption of the traditional kava preparation was reported to correlate with low and uncustomary gender ratios (more cancer in women than men) of cancer incidences in three kava-drinking countries: Fiji, Vanuatu, and Western Samoa. We have identified flavokawain A, B, and C but not the major kavalactone, kawain, in kava extracts as causing strong antiproliferative and apoptotic effect in human bladder cancer cells.
    METHODS AND RESULTS:
    Flavokawain A results in a significant loss of mitochondrial membrane potential and release of cytochrome c into the cytosol in an invasive bladder cancer cell line T24. These effects of flavokawain A are accompanied by a time-dependent decrease in Bcl-x(L), a decrease in the association of Bcl-x(L) to Bax, and an increase in the active form of Bax protein. Using the primary mouse embryo fibroblasts Bax knockout and wild-type cells as well as a Bax inhibitor peptide derived from the Bax-binding domain of Ku70, we showed that Bax protein was, at least in part, required for the apoptotic effect of flavokawain A. In addition, flavokawain A down-regulates the expression of X-linked inhibitor of apoptosis and survivin.
    CONCLUSIONS:
    Because both X-linked inhibitor of apoptosis and survivin are main factors for apoptosis resistance and are overexpressed in bladder tumors, our data suggest that flavokawain A may have a dual efficacy in induction of apoptosis preferentially in bladder tumors. Finally, the anticarcinogenic effect of flavokawain A was evident in its inhibitory growth of bladder tumor cells in a nude mice model (57% of inhibition) and in soft agar.
    In vivo:
    Cancer Prev Res (Phila). 2013 Dec;6(12):1365-75.
    Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model.[Pubmed: 24121102]
    Flavokawain A (FKA) is the predominant chalcone identified from the kava plant. We have previously shown that FKA preferentially inhibits the growth of p53 defective bladder cancer cell lines.
    METHODS AND RESULTS:
    Here, we examined whether FKA could inhibit bladder cancer development and progression in vivo in the UPII-SV40T transgenic model that resembles human urothelial cell carcinoma (UCC) with defects in the p53 and the retinoblastoma (Rb) protein pathways. Genotyped UPII-SV40T mice were fed orally with vehicle control (AIN-93M) or FKA (6 g/kg food; 0.6%) for 318 days starting at 28 days of age. More than 64% of the male mice fed with FKA-containing food survived beyond 318 days of age, whereas only about 38% of the male mice fed with vehicle control food survived to that age (P = 0.0383). The mean bladder weights of surviving male transgenic mice with the control diet versus the FKA diet were 234.6 ± 72.5 versus 96.1 ± 69.4 mg (P = 0.0002). FKA was excreted primarily through the urinary tract and concentrated in the urine up to 8.4 μmol/L, averaging about 38 times (males) and 15 times (females) more concentrated than in the plasma (P = 0.0001). FKA treatment inhibited the occurrence of high-grade papillary UCC, a precursor to invasive urothelial cancer, by 42.1%. A decreased expression of Ki67, survivin, and X-linked inhibitor of apoptotic proteins (XIAP) and increased expression of p27 and DR5, and the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive apoptotic cells were observed in the urothelial tissue of FKA-fed mice.
    CONCLUSIONS:
    These results suggest a potential of FKA in preventing the recurrence and progression of non-muscle-invasive UCC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
    5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
    10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
    50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
    100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮; 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone CFN70345 35241-54-4 C17H18O5 = 302.3 5mg QQ客服:3257982914
    2-甲氧基根皮素; 2'-O-Methylphloretin (4,2',4'-Trihydroxy-6'-methoxydihydrochalcone) CFN91680 111316-17-7 C16H16O5 = 288.3 5mg QQ客服:215959384
    4,2',4'-三羟基-6'-甲氧基查耳酮; Helichrysetin CFN97065 62014-87-3 C16H14O5 = 286.3 5mg QQ客服:2056216494
    2',4'-二羟基-4,6'-二甲氧基二氢查尔酮; 2,4-Dihydroxy-4,6-dimethoxydihydrochalcone CFN97962 75679-58-2 C17H18O5 = 302.3 5mg QQ客服:2056216494
    2',6'-二羟基-4,4'-二甲氧基查耳酮; 2',6'-Dihydroxy-4,4'-dimethoxychalcone CFN70304 20621-49-2 C17H16O5 = 300.3 5mg QQ客服:2159513211
    2',4'-二羟基-4,6'-二甲氧基查耳酮; 4-O-Methylhelichrysetin CFN96080 56121-44-9 C17H16O5 = 300.3 5mg QQ客服:3257982914
    4,4'-二羟基-2',6'-二甲氧基查耳酮 ; 2'-O-Methylhelichrysetin CFN97920 123316-64-3 C17H16O5 = 300.3 5mg QQ客服:3257982914
    黄卡瓦胡椒素C; Flavokawain C CFN90741 56798-34-6 C17H16O5 = 300.3 10mg QQ客服:2056216494
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮; Flavokawain A CFN98446 3420-72-2 C18H18O5 = 314.3 10mg QQ客服:2056216494
    2',4',6',4-四甲氧基查耳酮; 2',4',6',4-Tetramethoxychalcone CFN91683 94103-36-3 C19H20O5 = 328.4 5mg QQ客服:2159513211

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