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  • 2',6'-二羟基-4,4'-二甲氧基查耳酮

    2',6'-Dihydroxy-4,4'-dimethoxychalcone

    2',6'-二羟基-4,4'-二甲氧基查耳酮
    产品编号 CFN70304
    CAS编号 20621-49-2
    分子式 = 分子量 C17H16O5 = 300.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The herbs of Cephalotaxus sinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2',6'-二羟基-4,4'-二甲氧基查耳酮 CFN70304 20621-49-2 1mg QQ客服:1413575084
    2',6'-二羟基-4,4'-二甲氧基查耳酮 CFN70304 20621-49-2 5mg QQ客服:1413575084
    2',6'-二羟基-4,4'-二甲氧基查耳酮 CFN70304 20621-49-2 10mg QQ客服:1413575084
    2',6'-二羟基-4,4'-二甲氧基查耳酮 CFN70304 20621-49-2 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell Signal.2022, 99:110433.
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  • Phytomedicine.2018, 38:12-23
  • Drug Chem Toxicol.2020, 1-14.
  • Food Bioscience2023, 56:103311.
  • Environ Toxicol.2023, 23929.
  • Plant Physiol Biochem.2023, 203:108073.
  • J Nat Prod.2015, 78(6):1339-4
  • Biomolecules.2021, 11(10):1537.
  • Front Plant Sci.2022, 13:982771.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Phytomedicine.2022, 100:154036.
  • Cell Rep.2020, 32(11):108158.
  • LWT2021, 138:110630.
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  • International J of Green Pharmacy2019, 13(3)
  • J Drug Target.2016, 24:1-28
  • Metabolites.2020, 11(1):E11.
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Onco Targets Ther.2017, 10:3467-3474
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  • ...
  • 生物活性
    Description: 2',6'-Dihydroxy-4,4'-dimethoxychalcone has asymmetric catalysis.
    In vitro:
    European Journal of Organic Chemistry, 2007.
    Asymmetric Cyclization of 2′‐Hydroxychalcones to Flavanones: Catalysis by Chiral Brønsted Acids and Bases.[Reference: WebLink]
    The asymmetric cyclization of 2′‐hydroxychalcones to flavanones is a basic, enzyme‐catalyzed step in the biosynthesis of flavonoid natural products, but poses a long‐standing problem for asymmetric catalysis with small molecule catalysts.
    METHODS AND RESULTS:
    Earlier claims concerning the realization of an asymmetric flavanone synthesis by means of camphorsulfonic acid as chiral Brønsted acid catalysts were reinvestigated using accurate HPLC methods for quantification of enantiomer ratios. The previous claims of asymmetric induction were thus shown to be untenable. On the other hand, cinchona alkaloids serve as chiral Brønsted base mediators for the asymmetric cyclization of either 6′‐substituted 2′‐hydroxychalcones or 2′,6′‐dihydroxychalcones. 2',6'-Dihydroxy-4,4'-dimethoxychalcone, for instance, cyclized to give the naturally occurring naringenin‐4′,7‐dimethyl ether in up to 64 % ee at 81 % conversion. The catalysis shows a marked dependency of the enantiomeric excess of the product on the catalyst, solvent and reactant concentration.
    CONCLUSIONS:
    Based on these successful examples of asymmetric cyclizations of 2′‐hydroxychalcones to flavanones, requirements for more active asymmetric catalysts can be defined.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-甲氧基根皮素; 2'-O-Methylphloretin (4,2',4'-Trihydroxy-6'-methoxydihydrochalcone) CFN91680 111316-17-7 C16H16O5 = 288.3 5mg QQ客服:215959384
    4,2',4'-三羟基-6'-甲氧基查耳酮; Helichrysetin CFN97065 62014-87-3 C16H14O5 = 286.3 5mg QQ客服:1413575084
    2',4'-二羟基-4,6'-二甲氧基二氢查尔酮; 2,4-Dihydroxy-4,6-dimethoxydihydrochalcone CFN97962 75679-58-2 C17H18O5 = 302.3 5mg QQ客服:2159513211
    2',6'-二羟基-4,4'-二甲氧基查耳酮; 2',6'-Dihydroxy-4,4'-dimethoxychalcone CFN70304 20621-49-2 C17H16O5 = 300.3 5mg QQ客服:2056216494
    2',4'-二羟基-4,6'-二甲氧基查耳酮; 4-O-Methylhelichrysetin CFN96080 56121-44-9 C17H16O5 = 300.3 5mg QQ客服:2159513211
    4,4'-二羟基-2',6'-二甲氧基查耳酮 ; 2'-O-Methylhelichrysetin CFN97920 123316-64-3 C17H16O5 = 300.3 5mg QQ客服:2159513211
    黄卡瓦胡椒素C; Flavokawain C CFN90741 56798-34-6 C17H16O5 = 300.3 10mg QQ客服:215959384
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮; Flavokawain A CFN98446 3420-72-2 C18H18O5 = 314.3 10mg QQ客服:1413575084
    2',4',6',4-四甲氧基查耳酮; 2',4',6',4-Tetramethoxychalcone CFN91683 94103-36-3 C19H20O5 = 328.4 5mg QQ客服:2159513211
    2',4'-二羟基-2,3',6'- 三甲氧基查尔酮; 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone CFN99015 100079-39-8 C18H18O6 = 330.3 5mg QQ客服:1413575084

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