| In vivo: |
| Chinese Journal of Hospital Pharmacy, 2003 , 23 (9) :532-3. | | The anti-tumor effect of the extract from Radix Pulsatillae[Reference: WebLink] | To extract anemosapogenin from Radix Pulsatillae and study its anti tumor activity.
METHODS AND RESULTS:
Total saponins were isolated from Radix Pulsatillae , then hydrolyze into sapogenins , the sapogenins were purified by column chromatography. The furified substance was mixed with vegetable oil as suspension of different concentrations. Mice with transplantable tumors(HepA liver carcinoma, Ehrlich ascites cancer)were administrated continuously for ten days by i.p. with different dosages according to the mice weight. The anti tumor effect in vivo and the rate of life elongation of the mice was observed. Low concentration group and middle concentration group had obvious effect on inhibiting the growth of HepA liver carcinoma in vivo, but the high concentration group had little effect . However, the life elongation effect was not obvious.
CONCLUSIONS:
The extract from Radix Pulsatillael (3b,23 dihydroxyl 20(29) lupene 28 acid)shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed. |
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Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
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