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  • 3',4',7,8-四羟基黄酮

    3',4',7,8-Tetrahydroxyflavone

    3',4',7,8-四羟基黄酮
    产品编号 CFN70342
    CAS编号 3440-24-2
    分子式 = 分子量 C15H10O6 = 286.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Rhus succedanea L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3',4',7,8-四羟基黄酮 CFN70342 3440-24-2 1mg QQ客服:215959384
    3',4',7,8-四羟基黄酮 CFN70342 3440-24-2 5mg QQ客服:215959384
    3',4',7,8-四羟基黄酮 CFN70342 3440-24-2 10mg QQ客服:215959384
    3',4',7,8-四羟基黄酮 CFN70342 3440-24-2 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite de Lille1 (France)
  • Medical University of Gdansk (Poland)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Imperial College London (United Kingdom)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • University of Eastern Finland (Finland)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Korea Food Research Institute(KFRI) (Korea)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Wollongong (Australia)
  • Mahidol University (Thailand)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Florida A&M University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine2022, 104:154318
  • J Sep Sci.2020, 201901140
  • Bio-protocol2018, 9(14):e3301
  • Molecules.2021, 26(18):5665.
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Phytomedicine.2015, 22(11):1027-36
  • Molecules.2019, 24(1):E159
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Mol Biol Rep.2022, doi: 10.1007
  • Food Res Int.2022, 157:111207.
  • Vietnam J. Chem.2023, 61(3),308-317
  • Mol Cells.2015, 38(9):765-72
  • Int. J. Mol. Sci.2023, 24(20),15294.
  • ACS Chem Biol.2019, 14(5):873-881
  • J Ethnopharmacol.2017, 198:91-97
  • Front Pharmacol.2021, 12:615157.
  • Molecules.2015, 20(11):20014-30
  • Phytochem Anal.2013, 24(5):493-503
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Molecules.2019, 24(4):E709
  • Cell Death Dis.2019, 10(12):882
  • Institut Pasteur Korea2020, doi: 10.21203.
  • ...
  • 生物活性
    Description: 3',4',7,8-Tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases. 3',4',7,8-Tetrahydroxyflavone exhibits antibacterial activity against S. mutans. It can absorb UV light and form photooxidation derivatives.
    Targets: Antifection | RANKL | c-Fos | NFATc1
    In vitro:
    Die Pharmazie, 01 Mar 2017, 72(3):161-166.
    3',4',7,8-Tetrahydroxyflavone inhibits RANKL-induced osteoclast formation and bone resorption.[Reference: WebLink]
    Osteoclasts, which are specialized bone multinuclear cells, are responsible for bone lytic diseases such as osteoporosis. 3',4',7,8-tetrahydroxyflavone is a flavonoid from Acacia confusa.
    METHODS AND RESULTS:
    In the present study, we found that 3',4',7,8-tetrahydroxyflavone markedly inhibited receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs). 3',4',7,8-tetrahydroxyflavone also reduced the mRNA expression levels of osteoclastic marker genes including the calcitonin receptor (CTR) and cathepsin K. In addition, 3',4',7,8-tetrahydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3',4',7,8-tetrahydroxyflavone inhibited RANKL-induced expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, ectopic overexpression of a constitutively active form of NFATc1 completely rescued the anti-osteoclastogenic effect of 3',4',7,8-tetrahydroxyflavone, suggesting that the anti-osteoclastogenic effect was mainly attributed to the reduction in NFATc1 expression.
    CONCLUSIONS:
    Taken together, our data suggest that 3',4',7,8-tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases.
    Archives of Pharmacal Research, 2013, 36(6):723-730.
    Antibacterial substances fromAlbizia myriophyllawood against cariogenicStreptococcus mutans.[Reference: WebLink]
    Albizia myriophylla has been used for long by Thai traditional healers as an important ingredient herb in Thai herbal formulas for caries.
    METHODS AND RESULTS:
    In this study, three flavonoids lupinifolin (6), 8-methoxy-7,3',4'-trihydroxyflavone (7), and 7,8,3',4'-tetrahydroxyflavone (3',4',7,8-Tetrahydroxyflavone,8), a triterpenoid lupeol (3) as well as four sterols β-sitosterone (1), stigmasta-5,22-dien-3-one (2), β-sitosterol (4), and stigmasterol (5) were isolated from A. myriophylla wood. The antibacterial activity of these compounds against Streptococcus mutans ATCC 25175 was performed using broth microdilution method. All compounds exhibited antibacterial activity against S. mutans with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) ranging from 1-256 and 2-256 μg/ml, respectively. Among the isolated compounds, lupinifolin (6) was found to be the most potent with MIC and MBC of 1 and 2 μg/ml, respectively. Lupinifolin (6) also showed a strong activity against ten clinical isolates of S. mutans with MIC and MBC ranging from 0.25-2 and 0.5-8 μg/ml, respectively.
    CONCLUSIONS:
    These results reported the bioactive ingredients of A. myriophylla which support its ethnomedical claims as well. Lupinifolin (6) may have a potential to be a natural anticariogenic agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4941 mL 17.4703 mL 34.9406 mL 69.8812 mL 87.3515 mL
    5 mM 0.6988 mL 3.4941 mL 6.9881 mL 13.9762 mL 17.4703 mL
    10 mM 0.3494 mL 1.747 mL 3.4941 mL 6.9881 mL 8.7352 mL
    50 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.3976 mL 1.747 mL
    100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.6988 mL 0.8735 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基-4'-甲氧基黄酮; 7-Hydroxy-4'-methoxyflavone CFN70378 487-24-1 C16H12O4 = 268.3 5mg QQ客服:1457312923
    3',4'-二羟基黄酮; 3',4'-Dihydroxyflavone CFN70360 4143-64-0 C15H10O4 = 254.2 20mg QQ客服:2159513211
    3',4'-二甲氧基黄酮; 3',4'-Dimethoxyflavone CFN70359 4143-62-8 C17H14O4 = 282.3 20mg QQ客服:2159513211
    3',4',7-三羟基黄酮; 7,3',4'-Trihydroxyflavone CFN97786 2150-11-0 C15H10O5 = 270.24 20mg QQ客服:2159513211
    3',4',7,8-四羟基黄酮; 3',4',7,8-Tetrahydroxyflavone CFN70342 3440-24-2 C15H10O6 = 286.2 5mg QQ客服:3257982914
    木犀草素; 3',4',5,7-四羟基黄酮; Luteolin CFN98784 491-70-3 C15H10O6 = 286.2 20mg QQ客服:215959384
    羟基芫花素; Hydroxygenkwanin CFN98021 20243-59-8 C16H12O6 = 300.3 20mg QQ客服:1413575084
    5,7-二甲氧基木犀草素; 5,7-Dimethoxyluteolin CFN91001 N/A C17H14O6 = 314.3 10mg QQ客服:1457312923
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:1413575084
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 20mg QQ客服:1457312923

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