4-氨基丁酸
4-Aminobutanoic acid
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 4-氨基丁酸 |
CFN90028 |
56-12-2 |
10mg |
QQ客服：1413575084 |
| 4-氨基丁酸 |
CFN90028 |
56-12-2 |
20mg |
QQ客服：1413575084 |
| 4-氨基丁酸 |
CFN90028 |
56-12-2 |
50mg |
QQ客服：1413575084 |
| 4-氨基丁酸 |
CFN90028 |
56-12-2 |
100mg |
QQ客服：1413575084 |
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Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age, suggests treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.
|
| Targets: |
Sodium Channel | ATPase | Potassium Channel |
| In vivo: |
| Depress Anxiety. 2014 Oct;31(10):814-21. | | Anxiety in major depression and cerebrospinal fluid free 4-Aminobutanoic acid.[Pubmed: 24865448] | Low 4-Aminobutanoic acid (GABA) is implicated in both anxiety and depression pathophysiology. They are often comorbid, but most clinical studies have not examined these relationships separately.
METHODS AND RESULTS:
We investigated the relationship of cerebrospinal fluid (CSF) free 4-Aminobutanoic acid to the anxiety and depression components of a major depressive episode (MDE) and to monoamine systems. Psychic anxiety severity increased with age and correlated with lower CSF free 4-Aminobutanoic acid, controlling for age. CSF free 4-Aminobutanoic acid declined with age but was not related to depression severity. Other monoamine metabolites correlated positively with CSF 4-Aminobutanoic acid but not with psychic anxiety or depression severity. CSF free 4-Aminobutanoic acid was lower in MDD compared with bipolar disorder and healthy volunteers. 4-Aminobutanoic acid levels did not differ based on a suicide attempt history in mood disorders. Recent exposure to benzodiazepines, but not alcohol or past alcoholism, was associated with a statistical trend for more severe anxiety and lower CSF 4-Aminobutanoic acid.
CONCLUSIONS:
Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age. This relationship is not seen with monoamine metabolites, suggesting treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
9.6974 mL |
48.4872 mL |
96.9744 mL |
193.9488 mL |
242.436 mL |
| 5 mM |
1.9395 mL |
9.6974 mL |
19.3949 mL |
38.7898 mL |
48.4872 mL |
| 10 mM |
0.9697 mL |
4.8487 mL |
9.6974 mL |
19.3949 mL |
24.2436 mL |
| 50 mM |
0.1939 mL |
0.9697 mL |
1.9395 mL |
3.879 mL |
4.8487 mL |
| 100 mM |
0.097 mL |
0.4849 mL |
0.9697 mL |
1.9395 mL |
2.4244 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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