4-氨基丁酸

4-Aminobutanoic acid

	产品编号	CFN90028
	CAS编号	56-12-2
	分子式 = 分子量	C₄H₉NO₂ = 103.12
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	From Monascus pilosus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
4-氨基丁酸	CFN90028	56-12-2	10mg	QQ客服：2159513211
4-氨基丁酸	CFN90028	56-12-2	20mg	QQ客服：2159513211
4-氨基丁酸	CFN90028	56-12-2	50mg	QQ客服：2159513211
4-氨基丁酸	CFN90028	56-12-2	100mg	QQ客服：2159513211

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sant Gadge Baba Amravati University (India)

Guangzhou Institutes of Biomedicine and Health (China)

Universiti Putra Malaysia(UPM) (Malaysia)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Korea Food Research Institute(KFRI) (Korea)

University of Illinois (USA)

Martin Luther University of Halle-Wittenberg (Germany)

Amity University (India)

University of the Basque Country (Spain)

University of Madras (India)

Copenhagen University (Denmark)

Griffith University (Australia)

Monash University (Australia)

Kyushu University (Japan)

More...

Description:

Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age, suggests treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.

Targets:

Sodium Channel | ATPase | Potassium Channel

In vivo:

Depress Anxiety. 2014 Oct;31(10):814-21.

Anxiety in major depression and cerebrospinal fluid free 4-Aminobutanoic acid.[Pubmed: 24865448]

Low 4-Aminobutanoic acid (GABA) is implicated in both anxiety and depression pathophysiology. They are often comorbid, but most clinical studies have not examined these relationships separately.
METHODS AND RESULTS:
We investigated the relationship of cerebrospinal fluid (CSF) free 4-Aminobutanoic acid to the anxiety and depression components of a major depressive episode (MDE) and to monoamine systems. Psychic anxiety severity increased with age and correlated with lower CSF free 4-Aminobutanoic acid, controlling for age. CSF free 4-Aminobutanoic acid declined with age but was not related to depression severity. Other monoamine metabolites correlated positively with CSF 4-Aminobutanoic acid but not with psychic anxiety or depression severity. CSF free 4-Aminobutanoic acid was lower in MDD compared with bipolar disorder and healthy volunteers. 4-Aminobutanoic acid levels did not differ based on a suicide attempt history in mood disorders. Recent exposure to benzodiazepines, but not alcohol or past alcoholism, was associated with a statistical trend for more severe anxiety and lower CSF 4-Aminobutanoic acid.
CONCLUSIONS:
Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age. This relationship is not seen with monoamine metabolites, suggesting treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4-甲氧基香豆素; 4-Methoxycoumarine	CFN94403	20280-81-3	C₁₀H₈O₃ = 176.17	20mg	QQ客服：1457312923
Isobellendine; Isobellendine	CFN00199	72362-45-9	C₁₂H₁₅NO₂ = 205.26	5mg	QQ客服：2159513211
构树宁E; Broussonin E	CFN97474	90902-21-9	C₁₇H₂₀O₄ = 288.3	5mg	QQ客服：1413575084
达帕菲尼; Dabrafenib	CFN60005	1195765-45-7	C₂₃H₂₀F₃N₅O₂S₂ = 519.6	5mg	QQ客服：1413575084

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	9.6974 mL	48.4872 mL	96.9744 mL	193.9488 mL	242.436 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL	38.7898 mL	48.4872 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL	19.3949 mL	24.2436 mL
50 mM	0.1939 mL	0.9697 mL	1.9395 mL	3.879 mL	4.8487 mL
100 mM	0.097 mL	0.4849 mL	0.9697 mL	1.9395 mL	2.4244 mL