三(羟甲基)甲基甘氨酸

Tricine

	产品编号	CFN98511
	CAS编号	5704-04-1
	分子式 = 分子量	C₆H₁₃NO₅ = 179.17
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Miscellaneous
	植物来源	The roots of Beta vulgaris
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	10mg	QQ客服：2159513211
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	20mg	QQ客服：2159513211
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	50mg	QQ客服：2159513211
三(羟甲基)甲基甘氨酸	CFN98511	5704-04-1	100mg	QQ客服：2159513211

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Limpopo (South Africa)

University of Wollongong (Australia)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Osmania University (India)

University of Otago (New Zealand)

University of Malaya (Malaysia)

Uniwersytet Medyczny w ?odzi (Poland)

Sanford Burnham Prebys Medical Discovery Institute (USA)

University of Eastern Finland (Finland)

Nicolaus Copernicus Uniwersity (Poland)

Universidad Miguel Hernández (Spain)

National Chung Hsing University (Taiwan)

Monash University Sunway Campus (Malaysia)

Mahidol University (Thailand)

More...

Description:

Tricine can clearly visualize tumors, may as melanoma imaging agents. Using the combination of tricine and a phosphine ligand, HYNIC-derivatized peptides or other small molecules can be labeled with 99mTc in high specific activity and with high stability for potential use as radiopharmaceuticals.

In vitro:

J. Immunol. Methods,1990 Jan 24;1 26(1):109-17.

Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis.[Pubmed: 2106001]

METHODS AND RESULTS:
We utilized the recently described tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis (TSDS-PAGE) system to study the lipooligosaccharides (LOS) and lipopolysaccharides (LPS) of gram negative bacteria. TSDS-PAGE resulted in a high degree of resolution of LOS and LPS in the 'mini-gel' format. TSDS-PAGE resulted in the LOS and LPS migrating as a function of their Mr during electrophoresis and allowed estimation of Mr from a protein standard. Several species of LOS were analyzed.
CONCLUSIONS:
The newly described procedure allowed a more rapid and accurate analysis of LOS and the core region of LPS.

In vivo:

Anticancer Agents Med Chem. 2014;15(1):122-30.

Evaluation of tricine and EDDA as Co-ligands for 99mTc-labeled HYNIC-MSH analogs for melanoma imaging.[Pubmed: 25175799 ]

Several radiolabeled alpha-melanocyte stimulating hormone (α-MSH) analogs have been studied for their abilities to target melanoma tumor cells through specific recognition and binding to the melanocortin receptor 1 (MCR1).
METHODS AND RESULTS:
In this work, a lactam bridgecyclized α-MSH analog was labeled with (99m) via the hydrazinonicotinamide (HYNIC) chelator and characterized for its melanoma tumor targeting properties. The bifunctional chelating agent HYNIC-Boc was attached to the N-terminus of the MSH peptide followed by the lactam cyclization, resulting in the HYNIC-cyc-MSH analog. The lactam cyclized peptide displayed high affinity and specificity for MC1-receptors present on B16/F1 melanoma tumor cells, exhibiting an IC50 of 6.48 nM. HYNIC-cyc-MSH was radiolabeled with (99m)Tc using two common co-ligands, tricine and EDDA. In vitro, the radiochemical stability, cell binding and efflux properties were similar between the peptides radiolabeled with tricine and EDDA as co-ligands. In vivo, biodistribution studies (n=4) demonstrated that (99m)Tc- HYNIC-cyc-MSH/tricine had superior tumor to muscle and tumor to blood ratios than (99m)Tc-HYNIC-cyc-MSH/EDDA at early time points.
CONCLUSIONS:
Planar gamma imaging of melanoma bearing mice showed that 99mTc-HYNIC-cyc-MSH/tricine was able to clearly visualize tumors, underscoring the potential utility of (99m)Tc labeled lactam cyclized MSH molecules as melanoma imaging agents.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.5813 mL	27.9065 mL	55.8129 mL	111.6258 mL	139.5323 mL
5 mM	1.1163 mL	5.5813 mL	11.1626 mL	22.3252 mL	27.9065 mL
10 mM	0.5581 mL	2.7906 mL	5.5813 mL	11.1626 mL	13.9532 mL
50 mM	0.1116 mL	0.5581 mL	1.1163 mL	2.2325 mL	2.7906 mL
100 mM	0.0558 mL	0.2791 mL	0.5581 mL	1.1163 mL	1.3953 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
麦冬皂苷C; Ophiopogonin C	CFN98556	911819-08-4	C₄₆H₇₂O₁₇ = 897.06	5mg	QQ客服：3257982914
2alpha-羟基泽兰内酯; 2-Hydroxyeupatolide	CFN90346	72229-33-5	C₁₅H₂₀O₄ = 264.32	5mg	QQ客服：1457312923
Clovin; Clovin	CFN90913	81970-00-5	C₃₃H₄₀O₂₀ = 756.66	5mg	QQ客服：1413575084
6alpha-羟基美迪紫檀素; 6alpha-Hydroxymedicarpin	CFN96029	61135-92-0	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：215959384

三(羟甲基)甲基甘氨酸

Tricine

信息支持

联系方式