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  • 3-O-阿魏酰奎尼酸

    3-O-Feruloylquinic acid

    3-O-阿魏酰奎尼酸
    产品编号 CFN92393
    CAS编号 1899-29-2
    分子式 = 分子量 C17H20O9 = 368.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The fruits of Coffea canephorra var. Robusta
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-O-阿魏酰奎尼酸 CFN92393 1899-29-2 1mg QQ客服:215959384
    3-O-阿魏酰奎尼酸 CFN92393 1899-29-2 5mg QQ客服:215959384
    3-O-阿魏酰奎尼酸 CFN92393 1899-29-2 10mg QQ客服:215959384
    3-O-阿魏酰奎尼酸 CFN92393 1899-29-2 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Canterbury (New Zealand)
  • National Chung Hsing University (Taiwan)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Padjajaran (Indonesia)
  • Universidad de La Salle (Mexico)
  • Mendel University in Brno (Czech Republic)
  • Universite de Lille1 (France)
  • Kyoto University (Japan)
  • VIT University (India)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Lund University (Sweden)
  • S.N.D.T. Women's University (India)
  • Universidad Industrial de Santander (Colombia)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • RSC Adv.2018, 32621-32636
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Molecules.2021, 26(23):7390.
  • Korean J of Medicinal Crop Science2018, 220-226
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Molecules.2022, 27(21):7514.
  • Key Engineering Materials2022, 931(47-53).
  • Journal of Ginseng Research2021, 25 November
  • J Sep Sci.2020, 201901140
  • Int J Mol Sci.2022, 23(15):8687.
  • Journal of Life Science2017, 233-240
  • Front Cell Dev Biol.2021, 9:588093.
  • Sci. Rep.2015, 14-23
  • Biochem Pharmacol.2017, 130:10-20
  • Phytochem Anal.2013, 24(5):493-503
  • Arch Biochem Biophys.2018, 644:93-99
  • Vietnam Journal of Food Control2022, 5(3):pp.390-401.
  • Plant Sci.2021, 313:111069.
  • Curr Issues Mol Biol.2022, 44(10):5106-5116.
  • Eur J Pharmacol.2021, 899:174010.
  • Journal of Apicultural Research2021, 60(1)
  • Sustainability2021, 13(23),12981.
  • ...
  • 生物活性
    Description: 3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
    Targets: Antifection | Proteasome | H5N1
    In vitro:
    Food Funct. 2013 Nov;4(11):1632-8.
    Isolation and quantification of major chlorogenic acids in three major instant coffee brands and their potential effects on H2O2-induced mitochondrial membrane depolarization and apoptosis in PC-12 cells.[Pubmed: 24061869]
    Coffee is a most consumed drink worldwide, with potential health effects on several chronic diseases including neuronal degenerative diseases. Chlorogenic acids (CHAs) are phenolic compounds found in coffee and they are reported to have strong antioxidant and anti-inflammatory activities. However, the amounts of CHAs often vary in coffee drinks and their potential effects on ROS-induced neuronal cell death still require more investigation.
    METHODS AND RESULTS:
    Therefore, in this paper, major CHAs were isolated from three major instant coffee brands, confirmed and quantified using HPLC and NMR spectroscopic methods. Then, their antioxidant activities and protective effects on H2O2-induced apoptosis in PC-12 cells were investigated using radical scavenging, mitochondrial membrane potential and caspase assays. In the coffee samples, three major CHAs (3-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, 5-O-caffeoylquinic acid) and some minor CHAs (3-O-feruloylquinic acid, 4-O-feruloylquinic acid, 5-O-feruloylquinic acid, 3,5-O-dicaffeoylquinic acid, 3,4-O-dicaffeoylquinic acid, and 4,5-O-dicaffeoylquinic acid) were detected. The three major CHAs were further isolated and their chemical structures were confirmed using NMR spectroscopic techniques. Also, the amounts of the three major CHAs were individually quantified using a HPLC method. At the concentration of 10 μM, all three major CHAs quenched DPPH and/or xanthine oxidase-generated radical species by 21-51% (P < 0.014). They also inhibited H2O2-induced mitochondrial membrane depolarization and caspase-9 activation by 27% (P < 0.034) and 50% (P < 0.05), respectively.
    CONCLUSIONS:
    This study suggests that the major CHAs found in coffee are likely to be potent antioxidant compounds able to quench radical species as well as inhibit H2O2-induced apoptosis via suppressing mitochondrial membrane depolarization and caspase-9 activation in the cells.
    Yao Xue Xue Bao. 2015 Feb;50(2):207-10.
    Chemical constituents of the roots of Macleaya microcarpa and activation efficacy of benzophenanthridine alkaloids for the transcription of xbp1 gene.[Pubmed: 25975030]
    Ongoing study on the chemical constituents of the roots of Macleaya microcarpa led to the isolation of eight compounds of derivatives of triterpenes and organic acids in addition to some previously identified benzophenanthridines.
    METHODS AND RESULTS:
    The eight compounds were identified by spectroscopic methods as well as comparison with literature values as 1-oxo-2, 22 (30)-hopandien-29-oic acid (1), 3-oxo-12-oleanen-30-oic acid (2), 3α-hydroxy-12-oleanen-30-oic acid (3), 3β-hydroxy-12-oleanen-30-oic acid (4), ferulic acid (5), ferulic acid 4-O-β-D-glucoside (6), 3-O-feruloylquinic acid (7), and methyl 3-O-feruloylquinate (8). Of which, 1 is a new triterpenoid of hopanes and 2-8 are isolated from M microcarpa for the first time. In order to discover natural active compounds as potential agents of anti-ulcerative colitis (UC), an in vitro drug high-throughput screening model targeted x-box-binding protein 1 (xbp1) was employed to evaluate the activity of the major chemical constituents of M microcarpa.
    CONCLUSIONS:
    The result confirmed that two dihydrobenzophenanthridines, dihydrosanguinarine (9) and dihydrochelerythrine (10), showed a certain activity on activating the transcription of xbpl, a transcription factor (TF) associated with the occurrence, development, and potential treatment of UC, with their relative activating ratios being 1.76 and 1.77 times, respectively, as compared with control group.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7152 mL 13.5759 mL 27.1518 mL 54.3036 mL 67.8794 mL
    5 mM 0.543 mL 2.7152 mL 5.4304 mL 10.8607 mL 13.5759 mL
    10 mM 0.2715 mL 1.3576 mL 2.7152 mL 5.4304 mL 6.7879 mL
    50 mM 0.0543 mL 0.2715 mL 0.543 mL 1.0861 mL 1.3576 mL
    100 mM 0.0272 mL 0.1358 mL 0.2715 mL 0.543 mL 0.6788 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid CFN92529 327161-03-5 C16H18O9 = 354.3 5mg QQ客服:215959384
    4-O-对香豆酰基奎宁酸; 4-O-Coumaroylquinic acid CFN95508 53539-37-0 C16H18O8 = 338.1 5mg QQ客服:2159513211
    隐绿原酸; Cryptochlorogenic acid CFN99117 905-99-7 C16H18O9 = 354.31 20mg QQ客服:1457312923
    甲基 4-咖啡酰奎尼酸酯; Methyl 4-caffeoylquinate CFN92528 123372-74-7 C17H20O9 = 368.3 5mg QQ客服:2159513211
    4-O-阿魏酰奎尼酸; 4-O-Feruloylquinic acid CFN92392 2613-86-7 C17H20O9 = 368.3 5mg QQ客服:215959384
    5-O-对香豆酰基奎宁酸; 5-O-Coumaroylquinic acid CFN95507 32451-86-8 C16H18O8 = 338.3 5mg QQ客服:215959384
    新绿原酸; Neochlorogenic acid CFN97472 906-33-2 C16H18O9 = 354.3 20mg QQ客服:2056216494
    新绿原酸甲酯; Neochlorogenic acid methyl ester CFN95190 123410-65-1 C17H20O9 = 368.3 5mg QQ客服:3257982914
    5-O-阿魏酰奎尼酸; 5-O-Feruloylquinic acid CFN92889 40242-06-6 C17H20O9 = 368.3 5mg QQ客服:1457312923
    甲基 5-O-阿魏酰奎尼酸酯; Methyl 5-O-feruloylquinate CFN92445 154461-64-0 C18H22O9 = 382.4 5mg QQ客服:2159513211

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